Acute Perniosis in Elderly People: A Predictive Sign of Systemic Disease?

Guadagni, Massimo; Nazzari, G

doi:10.2340/00015555-0918

Cited by 12 publications

(11 citation statements)

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“…Guadagni et al identified underlying disease in five of their seven patients and emphasized that the sudden onset of chilblains in the elderly, especially male patients, might be linked to systemic disease. 13 Consistent with this, Takci et al reported that the mean age of the group with secondary chilblains was significantly higher than the group with primary chilblains. 9 The occurrence of chilblains in children has been stated to be uncommon by Gardinal-Galera et al 12 but Takci et al 9 reported that 49% of patients in their study were aged between 0-18.…”

Section: Discussionmentioning

confidence: 67%

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Chilblains in Turkey: a case-control study

Akkurt

Uçmak

Yildiz

et al. 2014

An. Bras. Dermatol.

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BACKGROUNDChilblains are rather common in winter months in our country. OBJECTIVESDetermination of demographical and clinical characteristics of patients presenting with chilblains in Diyarbakir, Turkey. Evaluation of body mass index (BMI) as risk factor for development of chilblains. METHODSSixty-nine patients who were diagnosed as chilblains at our outpatient clinics were included in this study. No exclusion criteria were sought. Demographical data including height and weight and answers to questions related to personal history were recorded. A control group consisting of 108 controls were chosen from among patients presenting with complaints of hair loss. Statistical analyses were conducted using SPSS 17.0. RESULTSOf the 69 patients with chilblains, 45 (65.2%) were females and 24 (34.8%) were males. Mean age (±SD) of the patients was 21±9. 71.2% of the patients complained of itching, 51.6% of pain, 31.3% of burning in the lesions. 61.3% of the patients reported recurrence of the lesions every winter season. Mean BMI of the patients was 20.5±2.9. Mean BMI of the controls was 22.4±3.7 and the difference was statistically significant (p=0.01). CONCLUSIONSLow BMI may be a risk factor contributing to development of chilblains in persons exposed to cold weather conditions. Apart from external factors, there seems to be a personal tendency to develop lesions, as many patients report recurrences every year. Diagnosis of chilblains requires wariness, as history of cold exposure may not be evident.

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Section: Discussionmentioning

confidence: 67%

“…Extra attention should be paid to patients at the ends of the age spectrum, especially the elderly. 13 …”

Section: Discussionmentioning

confidence: 99%

Chilblains in Turkey: a case-control study

Akkurt

Uçmak

Yildiz

et al. 2014

An. Bras. Dermatol.

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“… 12 female gender was found to be significantly associated with chilblains and LE, and was also presented as a helpful clinical criterion for the differential diagnosis of IP and SP. In another study, Guadagni and Nazzari reported that the unexpected appearance of perniosis in elderly people, especially men, may be a predictive sign of an associated systemic disorder 13 …”

Section: Discussionmentioning

confidence: 99%

“…Although perniosis is a benign cold injury that causes no systemic symptoms in most cases, it can sometimes be a predictive sign of underlying systemic disorder 2,8,12,13,16 . There are very few data about the prevalence of associated CTDs in patients with perniosis.…”

Section: Discussionmentioning

confidence: 99%

“…Except for the case of subacute LE that developed in the eighth month of the follow-up, other associated disorders of cases in the SP group were determined at the first evaluation during the study. The median follow-up of patients was 16 months (range [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. No features of LE or any other CTDs developed during the follow-up of patients in the IP group, except in the single patient with subacute LE.…”

Section: Clinical and Laboratory Signs Of Connective-tissue Disordersmentioning

confidence: 99%

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Epidemiological patterns of perniosis, and its association with systemic disorder

Takçı

Vahaboğlu

Ekşioğlu

2012

Clinical and Experimental Dermatology

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Perniosis is not rare in children, but patients with secondary perniosis are more likely to be older. In terms of underlying systemic disorder, advanced age and male gender may be important demographic features. Measurement of cryoglobulin levels in the initial laboratory investigations of patients with perniosis is not necessary. Persistence beyond the cold seasons, and presence of photosensitivity, hypergammaglobulinaemia and rheumatoid factor may be useful in differentiating between idiopathic and secondary perniosis.

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