Acute perforation of colonic diverticula associated with prolonged adrenocorticosteroid therapy

Canter, Jerome W.; Shorb, Paul E.

doi:10.1016/0002-9610(71)90076-6

Cited by 82 publications

(24 citation statements)

References 5 publications

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“…Immunocompromised patients are susceptible to acute diverticulitis. In patients without transplants, long-term use of steroid therapy is associated with a high risk of acute colonic diverticulitis and perforation [5]. This fact is attributed to steroidal inhibition of the inflammatory response and to alteration of the fibroblastic activity.…”

Section: Discussionmentioning

confidence: 99%

Acute diverticulitis in heart transplant recipients

Detry¹,

Defraigne²,

Meurisse³

et al. 1996

Transplant Int

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Immunosuppressed patients are susceptible to complicated diverticulitis, but reports of this complication are scarce in heart graft recipients. To estimate the prevalence of acute diverticulitis in heart graft recipients, we retrospectively reviewed the cases of diverticulitis in a series of 143 patients who underwent orthotopic heart transplantation in a period of 10 years. Six (4 %) of these developed acute diverticulitis and required colectomy. All of them were male patients and were older than 50 years. Four patients underwent urgent laparotomy and colon resection with end colostomy (Hartmann procedure). The two other patients suffered from diverticulitis without generalized peritonitis and underwent laparoscopic sigmoidectomy with direct transanal end-to-end anastomosis. The postoperative outcomes of these six patients were satisfactory. As are other immunosuppressed patients, heart graft recipients are susceptible to diverticulitis. Early surgical management may be safe in well-compensated patients.

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Section: Discussionmentioning

confidence: 99%

Acute diverticulitis in heart transplant recipients

Detry¹,

Defraigne²,

Meurisse³

et al. 1996

Transplant Int

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“…Of the 151 patients included in the studies in Table 6, only 9 patients (6%) did not receive any surgical treatment throughout their entire disease course. 4,5,11,22,23,32 In the study by Warshaw et al, 11 2 patients received only conservative medical treatment and subsequently died. In both of these patients, perforation was diagnosed on the basis of postmortem examination.…”

Section: Treatment Outcomesmentioning

confidence: 99%

“…Three other patients underwent elective sigmoid resection postdischarge. 22,32 Surgery during an admission for acute diverticulitis was associated with a 23% (33/142) mortality. Patients who were conservatively managed and did not undergo surgery had a 56% mortality (5/9).…”

Section: Treatment Outcomesmentioning

confidence: 99%

Diverticulitis in Transplant Patients and Patients on Chronic Corticosteroid Therapy: A Systematic Review

Hwang

Cannom

Abbas

et al. 2010

Diseases of the Colon &Amp; Rectum

119

110

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“…Different diagnoses requiring surgical or conservative treatment are described [3][4][5][6][7][8][9] with varying outcome. There is only limited data on abdominal complications after LuTx with low numbers of patients included in the analyses [10][11][12][13][14][15]. Thus, we analysed the incidence and outcome of abdominal surgical interventions for the first time in such a large number of patients following LuTx at Hannover Medical School, Germany to define special risk constellations with a need for potentially differentiated advancement.…”

Section: Introductionmentioning

confidence: 99%