Acute Peptic Ulcer Disease Caused by Non-Helicobacter pylori-Helicobacter

Abstract

Human infection by Non-Helicobacter pylori-Helicobacter is rare and most commonly transmitted through direct contact with animals. The clinical presentation in most cases is chronic epigastric abdominal pain and it usually leads to chronic gastritis. We present an uncommon case of a patient with acute onset abdominal pain secondary to acute peptic ulcer disease caused by Helicobacter heilmannii who underwent successful treatment. We also conducted a review of the literature to understand the epidemiology, etiology, clinical presentation, and the best diagnostic and treatment modalities for Non-H. pylori-Helicobacter infections.

Draft Genome Sequence of Helicobacter sp. Strain CaF467b, Isolated from a Pig Manure Storage Tank

“…Helicobacter species are Gram-negative, curved bacilli commonly found in the gastrointestinal environment of humans ( 1 , 2 ) and animals ( 3 , 4 ). Recently, non- Helicobacter pylori species have been considered emerging human pathogens since they have been reported in clinical cases ( 5 – 7 ) that are often acquired through direct contact with infected animals ( 8 ). Therefore, there is an urgent need to understand the full nature of their pathogenesis.…”

Clinical presentation and outcomes of Helicobacter heilmannii gastritis in children in the New England region of the United States

“…2 Although H. heilmannii are distinct from the more commonly known Helicobacter pylori (H. pylori), the bacteria have been associated with similar symptoms, including dyspepsia and abdominal pain, as well as micro-and macroscopic inflammation in humans. [3][4][5] Gastric carcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma, though rare, have also been associated with the infection. 6,7 The diagnosis of H. heilmannii requires identification of the spiral-shaped bacteria during histologic examination of gastric mucosal biopsies obtained during an endoscopy.…”

“…Since Dent et al first reported on the presence of H. heilmannii in humans in 1987, 1 several subtypes ( H. suis, H. felis, H. bizzozeronii, H. salomonis, H. cynogastricus , and H. baculiformis ) have been identified using 16S RNA analysis 2 . Although H. heilmannii are distinct from the more commonly known Helicobacter pylori ( H. pylori ), the bacteria have been associated with similar symptoms, including dyspepsia and abdominal pain, as well as micro‐ and macroscopic inflammation in humans 3–5 . Gastric carcinoma, and mucosa‐associated lymphoid tissue (MALT) lymphoma, though rare, have also been associated with the infection 6,7 …”