Acute pectoral myopathy in broiler breeders

Randall, CJ

doi:10.1080/03079458208436098

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…Mounting evidence suggests that selection for such economically desirable traits in the modern broiler has been accompanied by reduced welfare (Julian, 1998; Knowles et al, 2008) and increased mortality (Havenstein et al, 1994a; Havenstein, Ferket & Qureshi, 2003a). Considerable research is being directed toward understanding welfare problems such as the multitude of leg pathologies that may affect locomotion in broiler chickens (Kestin et al, 1992; Bradshaw, Kirkden & Broom, 2002; Corr et al, 2003a; Corr et al, 2003b; Knowles et al, 2008; Paxton et al, 2010), cardiac (Wilson, Julian & Barker, 1988) and pectoral (Randall, 1982) myopathies, pulmonary hypertension (Wideman, 2001) and ascites (Wilson, Julian & Barker, 1988; Julian, 1993). The prevalence of these conditions indicates that further improvements in industry-efficiencies and meat production may be constrained by the physiological capabilities of broilers because skeletal, cardiac, respiratory and digestive systems appear to be close to their functional limit.…”

Section: Introductionmentioning

confidence: 99%

Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size

Tickle

Paxton

Rankin

et al. 2014

PeerJ

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Genetic selection for improved meat yields, digestive efficiency and growth rates have transformed the biology of broiler chickens. Modern birds undergo a 50-fold multiplication in body mass in just six weeks, from hatching to slaughter weight. However, this selection for rapid growth and improvements in broiler productivity is also widely thought to be associated with increased welfare problems as many birds suffer from leg, circulatory and respiratory diseases. To understand growth-related changes in musculoskeletal and organ morphology and respiratory skeletal development over the standard six-week rearing period, we present data from post-hatch cadaveric commercial broiler chickens aged 0, 2, 4 and 6 weeks. The heart, lungs and intestines decreased in size for hatch to slaughter weight when considered as a proportion of body mass. Proportional liver size increased in the two weeks after hatch but decreased between 2 and 6 weeks. Breast muscle mass on the other hand displayed strong positive allometry, increasing in mass faster than the increase in body mass. Contrastingly, less rapid isometric growth was found in the external oblique muscle, a major respiratory muscle that moves the sternum dorsally during expiration. Considered together with the relatively slow ossification of elements of the respiratory skeleton, it seems that rapid growth of the breast muscles might compromise the efficacy of the respiratory apparatus. Furthermore, the relative reduction in size of the major organs indicates that selective breeding in meat-producing birds has unintended consequences that may bias these birds toward compromised welfare and could limit further improvements in meat-production and feed efficiency.

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Section: Introductionmentioning

confidence: 99%

Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size

Tickle

Paxton

Rankin

et al. 2014

PeerJ

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“…Pectoral myopathies are not new in broiler poultry species, and broiler chicken particularly has a well-documented history of dystrophies and myopathies, including pectoral myopathies induced by physical or nutritional stress [12][13][14]. For example, Siller et al [15] reported deep pectoral myopathy in both turkeys and broiler chicken induced by exercise.…”

Section: Introductionmentioning

confidence: 99%

Insights into the molecular basis of wooden breast based on comparative analysis of fast- and slow-growth broilers

Hubert

Williams

Athrey

2018

Preprint

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Wooden breast has emerged as an important condition in the poultry industry and affects the breast muscle of commercial meat-type chickens (broilers). Thus far, the condition has been classified as a myopathy, confirmed to not have an infectious origin, with molecular data showing the muscle to be under oxidative stress. The objective in this study was to query the functional origins of wooden breast and reveal its molecular similarities to known conditions based on pathway analyses. To carry out an in-depth comparative analysis, we generated RNAseq data from wooden breast affected birds and incorporated breast specific transcriptomic data from previously published studies. The comparative datasets were constructed from a range of commercial fast-growth and slow-growth varieties. Analysis of high-impact variants identified from transcriptome data provided a list of genes important in cell signaling, cell proliferation, cytoskeletal development, and calcium metabolism as being affected by nucleotide changes.Overlaying the lists of significantly differentially expressed genes with the list of high-impact variants produced a list of twenty genes that suggest an association of mechanistic and functional causes for woody breast; supporting a polygenic basis for this condition. Our study demonstrates that wooden breast shows an age-dependent gene expression pattern, with pathway analysis showing enrichment of glycolysis, cell differentiation, tumor suppression and inhibition, further indicating a complex condition with few similarities to myopathies. In summary, our results indicate the existence of a mechanistic, heritable basis for wooden breast, the drivers of which deserve more in-depth investigation. Additionally, they also suggest wooden breast to be a more complex condition than previously reported, potentially involving other organ systems.3

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“…Mounting evidence suggests that selection for such economically desirable traits in the modern broiler has been accompanied by reduced welfare (Julian, 1998;Knowles, et al, 2008) and increased mortality (Havenstein, et al, 1994a;Havenstein, et al, 2003a). Considerable research is being directed toward understanding welfare problems such as the multitude of leg pathologies that may affect locomotion in broiler chickens (Kestin, et al, 1992;Bradshaw, et al, 2002;Corr, et al, 2003a;Corr, et al, 2003b;Knowles, et al, 2008;Paxton, et al, 2010), cardiac (Wilson, et al, 1988) and pectoral (Randall, 1982) myopathies, pulmonary hypertension (Wideman, 2001) and ascites (Wilson, et al, 1988;Julian, 1993). The prevalence of these conditions indicates that further improvements in industry-efficiencies and meat production may be constrained by the physiological capabilities of broilers because skeletal, cardiac, respiratory and digestive systems appear to be close to their functional limit.…”

Section: Introductionmentioning

confidence: 99%

Peer Review #1 of "Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size (v0.1)"

2014

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Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size. Genetic selection for improved meat yields, digestive efficiency and growth rates have transformed the biology of broiler chickens. Modern birds undergo a 50-fold multiplication in body mass in just six weeks, from hatching to slaughter weight. However, this selection for rapid growth and improvements in broiler productivity is also widely thought to be associated with increased welfare problems as many birds suffer from leg, circulatory and respiratory diseases. To understand growth-related changes in musculoskeletal and organ morphology and respiratory skeletal development over the standard six-week rearing period, we present data from post-hatch cadaveric commercial broiler chickens aged 0, 2, 4 and 6 weeks. The heart, lungs and intestines decreased in size for hatch to slaughter weight when considered as a proportion of body mass. Proportional liver size increased in the two weeks after hatch but decreased between 2 and 6 weeks. Breast muscle mass on the other hand displayed strong positive allometry, increasing in mass faster than the increase in body mass. Contrastingly, less rapid isometric growth was found in the external oblique muscle, a major respiratory muscle that moves the sternum dorsally during expiration. Considered together with the relatively slow ossification of elements of the respiratory skeleton, it seems that rapid growth of the breast muscles might compromise the efficacy of the respiratory apparatus. Furthermore, the relative reduction in size of the major organs indicates that selective breeding in meat-producing birds has unintended consequences that may bias these birds toward compromised welfare and could limit further improvements in meat-production and feed efficiency.

show abstract

Acute pectoral myopathy in broiler breeders

Cited by 9 publications

References 6 publications

Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size

Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size

Insights into the molecular basis of wooden breast based on comparative analysis of fast- and slow-growth broilers

Peer Review #1 of "Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size (v0.1)"

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