Acute paronychia after high-dose methotrexate therapy

Wantzin, G. L.

doi:10.1001/archderm.119.7.623

Cited by 9 publications

(2 citation statements)

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“…In the cases herein reported, they appeared with erythema under the nails, like transitory hemorrhages, associated with the typical orange discoloration [2, 4]. Acute paronychia is not a frequent finding with antineoplastic drugs but has been described with high-dose methotrexate [12]. Exsudative acute painful paronychia associated with onycholysis and orange discoloration (fig.…”

Section: Discussionmentioning

confidence: 99%

Nail Changes Secondary to Docetaxel (Taxotere)

Correia¹,

Azevedo²,

Ferreira

et al. 1999

Dermatology

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Docetaxel is a new taxoid antineoplastic drug widely used for advanced breast cancer. Skin and nail toxicity are one of the more frequent nonhematologic adverse reactions. Besides dark pigmentations and Beau’s lines, subungual hemorrhage, orange discoloration, acute painful paronychia, onycholysis, subungual hyperkeratosis and transverse loss of the nail plate are described. The type of nail alteration is related with the number of cycles administered and there are no efficacious preventive measures to avoid its development. Clinicians should recognize the clinical picture of these adverse nail reactions because docetaxel is used for several neoplastic disorders.

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