1983
DOI: 10.1001/archderm.119.7.623
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Acute paronychia after high-dose methotrexate therapy

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“…Chemotherapeutic agents have rarely been implicated in acute paronychia. However, the disorder has been reported after high‐doses of methotrexate and taxoids 3,4 . Acute paronychia in our patient was attributed to the use of lapatinib, because of the close temporal association of the condition 2 months after starting the drug.…”
mentioning
confidence: 62%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Chemotherapeutic agents have rarely been implicated in acute paronychia. However, the disorder has been reported after high‐doses of methotrexate and taxoids 3,4 . Acute paronychia in our patient was attributed to the use of lapatinib, because of the close temporal association of the condition 2 months after starting the drug.…”
mentioning
confidence: 62%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In the cases herein reported, they appeared with erythema under the nails, like transitory hemorrhages, associated with the typical orange discoloration [2, 4]. Acute paronychia is not a frequent finding with antineoplastic drugs but has been described with high-dose methotrexate [12]. Exsudative acute painful paronychia associated with onycholysis and orange discoloration (fig.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.