Acute paraplegia in a puppy with hemophilia A

Thompson, M S; Kreeger, Joseph

doi:10.5326/15473317-35-1-36

Cited by 12 publications

(21 citation statements)

References 8 publications

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“…Hemorrhage within the spinal cord (which is rarer) is called hematomyelia 4–6 . All types have been reported in dogs 7–12 . Intraspinal hemorrhage is most frequently induced by trauma but other causes include iatrogenic procedures such as lumbar puncture or spinal surgery, vascular lesions such as vascular malformations, hemorrhage related to tumors or vasculitis, and bleeding diatheses 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Intraspinal hemorrhage is most frequently induced by trauma but other causes include iatrogenic procedures such as lumbar puncture or spinal surgery, vascular lesions such as vascular malformations, hemorrhage related to tumors or vasculitis, and bleeding diatheses 4 . Those reported in dogs include bleeding diatheses, neoplasia, vasculitis, and vascular malformations 7–12 . Computed tomographic examination of the spinal cord of dogs after lumbar myelography has confirmed the presence of parenchymal hemorrhage, but not to the extent that has caused clinical signs 13 …”

Section: Discussionmentioning

confidence: 99%

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Hematomyelia Secondary to Lumbar Cerebrospinal Fluid Acquisition in a Dog

Platt

Dennis

Murphy

et al. 2005

Vet Radiology Ultrasound

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A 2-year-old male (Hungarian Vizsla) was evaluated for progressive discomfort of possible spinal origin. A minimum data base, thoracolumbar magnetic resonance (MR) imaging examination and electrophysiologic investigation were all normal. Cerebellomedullary and lumbar cerebrospinal fluid (CSF) was collected. The fluid was unremarkable except for elevated total protein. Shortly, thereafter, the dog had progressive neurologic deterioration referable to a caudal lumbar spinal cord lesion. In a repeated MR examination there was a well-circumscribed intramedullary lesion at the site where lumbar CSF was collected. The signal characteristics of the lesion were compatible with subacute hemorrhage, which was confirmed to be hematomyelia at the time of successful decompressive surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hematomyelia Secondary to Lumbar Cerebrospinal Fluid Acquisition in a Dog

Platt

Dennis

Murphy

et al. 2005

Vet Radiology Ultrasound

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“…There also are some case reports of hemorrhage around the spinal cord secondary to coagulopathies, such as Von Willebrand's Disease,7 brown snake envenomation,8 and hemophilia A 9. In addition, there are reports of hemorrhage associated with granular cell neoplasia in the lumbar spine,10 hemangiosarcoma in the thoracic spinal cord,11 trauma,12 and spinal surgery 13…”

mentioning

confidence: 99%

“…[1][2][3][4][5][6] There also are some case reports of hemorrhage around the spinal cord secondary to coagulopathies, such as Von Willebrand's Disease, 7 brown snake envenomation, 8 and hemophilia A. 9 In addition, there are reports of hemorrhage associated with granular cell neoplasia in the lumbar spine, 10 hemangiosarcoma in the thoracic spinal cord, 11 trauma, 12 and spinal surgery. 13 In human patients, the most common causes of extraparenchymal spinal cord hematoma include coagulopathies, anticoagulant treatment, vascular anomalies, intervertebral disk disease, neoplasia, and epidural catheters.…”

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confidence: 99%

Clinical, Magnetic Resonance Imaging, and Histopathologic Findings in 6 Dogs with Surgically resected Extraparenchymal Spinal Cord Hematomas

Hague

Joslyn

Bush³

et al. 2015

Veterinary Internal Medicne

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BackgroundExtraparenchymal spinal cord hematoma has been described in veterinary medicine in association with neoplasia, intervertebral disk disease, and snake envenomation. There are rare reports of spontaneous extraparenchymal spinal cord hematoma formation with no known cause in human medicine. Multiple cases of spontaneous extraparenchymal spinal cord hematoma have not been described previously in veterinary medicine.ObjectivesTo describe the signalment, clinical findings, magnetic resonance imaging (MRI) features, and surgical outcomes in histopathologically confirmed extraparenchymal spinal cord hematomas in dogs with no identified underlying etiology.AnimalsSix dogs had MRI of the spinal cord, decompressive spinal surgery, and histopathologic confirmation of extraparenchymal spinal cord hematoma not associated with an underlying cause.MethodsMulti‐institutional retrospective study.ResultsSix patients had spontaneous extraparenchymal spinal cord hematoma formation. MRI showed normal signal within the spinal cord parenchyma in all patients. All hematomas had T2‐weighted hyperintensity and the majority (5/6) had no contrast enhancement. All dogs underwent surgical decompression and most patients (5/6) returned to normal or near normal neurologic function postoperatively. Follow‐up of the patients (ranging between 921 and 1,446 days) showed no progression of neurologic clinical signs or any conditions associated with increased bleeding tendency.Conclusions and Clinical ImportanceBefore surgery and histopathology confirming extraparenchymal hematoma, the primary differential in most cases was neoplasia, based on the MRI findings. This retrospective study reminds clinicians of the importance of the combination of advanced imaging combined with histopathologic diagnosis. The prognosis for spontaneous spinal cord extraparenchymal hematoma with surgical decompression appears to be favorable in most cases.

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“…3 Intramedullary hemorrhage (hematomyelia) has been described in conjunction with trauma, coagulopathy (hereditary and acquired), tumors, and vascular malformations in humans and dogs. In dogs, SIEH with myelopathy has been described in association with lumbar puncture, vasculitis, spontaneous bleeding, and coagulopathies [6][7][8][9][10][11][12] but was also suspected on the basis of images obtained in cases of atlantoaxial subluxation and coagulopathies. In dogs, SIEH with myelopathy has been described in association with lumbar puncture, vasculitis, spontaneous bleeding, and coagulopathies [6][7][8][9][10][11][12] but was also suspected on the basis of images obtained in cases of atlantoaxial subluxation and coagulopathies.…”

Section: Commentsmentioning

confidence: 99%