Acute Pancreatitis may Occur in COVID-19 Patients with Clearance of SARS-CoV-2 in Lung: A Case Report

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is mostly causes lung damages, but also lead to gastroenterology injury. SARS-CoV-2 - associated acute pancreatitis has been reported, however, clearance of SARS-CoV-2 and the pancreatitis was not clear.Case presentation: A 62 year old diabetic female patient suffer from coronavirus diseases (COVID-19) and detection of SARS-CoV-2 turned negative on day 11 and day 12 in sputum. Two days latter, the patient was diagnosed with acute pancreatitis. Through the support treatment, the patient got better and discharged from our hospital 18 days later.Conclusions: Our case provided an initial view of SARS-CoV-2 infection with acute pancreatitis and the acute pancreatitis may occur in COVID-19 patients with clearance of SARS-CoV-2 in lung.

Single-Cell Transcriptome Analysis Reveals the Role of Pancreatic Secretome in COVID-19 Associated Multi-organ Dysfunctions

“…Emerging evidence indicates an intricate relationship between SARS-CoV-2 infection and multi-organ dysfunctions (MODs), which affects the lungs, heart, kidney, intestine, olfactory epithelium, liver, and pancreas [ 24 – 30 ]. Acute pancreatitis (AP) is an inflammation of the pancreas that results in local and systemic complications, as well as multiple organ malfunctions and damage over time [ 12 – 16 ]. SARS-CoV-2-induced multi-organ dysfunctions are currently mechanistically unclear.…”

“…Acute pancreatitis (AP) is triggered in the pancreas in response to an inflammatory event, leading to deleterious local and systemic effects [ 12 ] and eventually multi-organ damage and dysfunction [ 13 ]. There are cases of pancreatitis associated with no respiratory symptoms [ 14 , 15 ] and after the clearance of SARS-CoV-2 in the lungs [ 16 ] of the COVID-19 patients. While the precise mechanisms of SARS-CoV-2-induced acute pancreatitis remain unknown [ 17 – 19 ], AP pathogenesis is commonly attributed to trypsin activation and intracellular signalling [ 20 ], the release of proteolytic enzymes such as amylase and lipase [ 21 ], reactive oxygen species (ROS) [ 22 ], inflammatory elements, and the release of other mediators into the blood, all of which lead to the activation of the systemic inflammatory response [ 23 ].…”

Deciphering the role of the Pancreatic Secretome in Covid-19 associated Multi-Organ Dysfunctions

“…Acute pancreatitis (AP) initiates in the pancreas in response to an inflammatory event, leading to deleterious local and systemic effects (Götzinger et al, 2003) and eventually leads to multi-organ damage and dysfunction (Bhatia, 2009). There are cases of pancreatitis associated without respiratory symptoms (Kandasamy, 2020;Lakshmanan and Malik, 2020) and after the clearance of SARS-CoV-2 in the lungs (Zhao et al, 2020) of the COVID-19 patients. While the detailed mechanisms of SARS-CoV-2 induced acute pancreatitis are still under investigation (AlHarmi et al, 2021;de-Madaria et al, 2021;Ramos-Casals et al, 2021), the AP pathogenesis is commonly attributed to trypsin activation and intracellular signaling (Frossard, 2001), the release of proteolytic enzymes such as amylase and lipase (Tauseef et al, 2021), reactive oxygen species (ROS) (Tsuji et al, 1994), inflammatory elements, and release of other mediators into the blood, collectively leading to activation of the systemic inflammatory response (Bruen et al, 2021;Vege and Chari, 2021).…”