Acute pancreatitis in six non-transplanted uraemic children

Abstract

Ten clinical episodes of acute pancreatitis (AP) occurred in six patients (mean age 10 years, range 3-15 years) with chronic renal failure (CRF) during a 9-year period (1977-1986). The underlying cause of CRF was vesicoureteral reflux (2); urethral valves (1); ureterohydronephrosis (1); nephronopthisis (1) and a haemolytic uraemic syndrome which occurred 12 years before (1). In all patients a diagnosis of AP was established both on clinical grounds and with a serum amylase level of greater than 600 IU/l. In 3 patients laparotomy was performed because of suspected appendicitis. All patients required exclusive parenteral feeding (mean duration 25 days) and 2 patients had a partial pancreatectomy. No patient developed pancreatic pseudocysts, 2 patients experienced one relapse (3 and 21 months later) and 1 patient had two relapses and died. Mean duration of follow up was 3 years (range 1-10 years). Possible aetiological factors were: choledochal cyst (1); parotitis without a rise in mumps antibodies (1); familial dyslipidaemia but without AP in other family members (1), and aluminium intoxication with hypercalcaemia and convulsive encephalopathy treated with valproic acid in 1 patient. Severe hyperparathyroidism with radiological signs was absent in all patients. Transplantation had been performed either before AP in 2 patients (1 and 3 years before AP) or had followed AP in 1 patient (7 years after) without occurrence or relapse of AP.

Valproic Acid-Associated Acute Pancreatitis: Systematic Literature Review

“…For the final analysis, we retained 73 articles [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , …”

Acute pancreatitis in peritoneal dialysis

“…These consisted of 14 individual case reports [14][15][16][17][18][19][20][21][22][23][24][25][26][27], five case series [6,11,12,28,29] and nine population-based studies [2,4,[7][8][9][10]13,30,31] reporting a total of 94 cases with 133 episodes of pancreatitis from 1985 to 2011. Only articles in English and those describing cases of AP in PD patients were included.…”

“…In our literature search in which history of peritonitis was reported, 61.4% of patients had one or more previous episodes of peritonitis (Table 1) Presentation of AP is similar to the often occurring complication of PD-associated peritonitis and diagnosis can often be delayed because of this. Diagnosis of AP was delayed in 11 patients [11,12,15,16,18,19,21,25,27]; eight patients were diagnosed initially with PD-associated peritonitis [11,15,16,18,19,21,25] and the diagnosis in three cases was not confirmed until autopsy [13]. Diagnosis of AP was delayed in 11 patients [11,12,15,16,18,19,21,25,27]; eight patients were diagnosed initially with PD-associated peritonitis [11,15,16,18,19,21,25] and the diagnosis in three cases was not confirmed until autopsy [13].…”

“…; however, in only 20 out of 75 (26.7%) episodes was there any evidence of coexistent or preceding peritonitis with AP[4,6,7,[10][11][12][13][14][15][16][17][18][19][20][21][22][25][26][27][28]31].…”

Pancreatitis Is a Silent Killer in Peritoneal Dialysis With Difficult Diagnostic Approach

“…A search of the current literature was performed using the PubMed database which let us to take 168 articles, analyzing them and adding others from bibliography database, we obtained 236 cases of pancreatitis in peritoneal dialysis (PD) (17 case reports, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] 5 case series, [18][19][20][21][22] 11 population-based studies [23][24][25][26][27][28][29][30][31][32][33] ).…”