Acute pancreatitis in children hospitalized with COVID-19

Suchman, Kelly; Raphael, Kara L.; Liu, Yan; Wee, Diana; Trindade, Arvind J.

doi:10.1016/j.pan.2020.12.005

Cited by 29 publications

(27 citation statements)

References 8 publications

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“…A series of three children was illustrated in the report by Samies et al on October 2020 ( 17 ). In December, Suchman et al mentioned a 1.8% covid-19 positivity in hospitalized children with acute pancreatitis ( 18 ). Earlier this year, Damaan et al and Bineshfar et al described 2 more cases of COVID-19 and pancreatitis ( 19 , 20 ).…”

Section: Discussionmentioning

confidence: 99%

Acute Pancreatitis in COVID-19-associated Multisystem Inflammatory Syndrome of Children—A Single Center Experience

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Acute Pancreatitis in COVID-19-associated Multisystem Inflammatory Syndrome of Children—A Single Center Experience

et al. 2021

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“…Thirteen patients were diagnosed with acute pancreatitis (prevalence 0.16%) and only two of them had COVID-19. According to their study, the prevalence of AP in children with COVID-19 was higher than in the non-COVID-19 population (1.8% vs. 0.14%, respectively) [15]. Other reports include a case of a 7-year-old girl that developed necrotizing pancreatitis two weeks prior to her positive test for SARS-CoV-2 infection and a case of a 10-year-old patient with an acute pancreatitis as a presentation of multisystem inflammatory syndrome in children (MIS-C) [16,17].…”

Section: Discussionmentioning

confidence: 90%

“…The histopathological pancreatic changes associated with SARS-CoV-2 infection are as follows: degeneration of the islet cells, pancreatitis (from microscopic acute inflammation to necrotic-hemorrhagic lesions) [7,14]. In the literature there are cases of acute pancreatitis in the course of COVID-19, but only a few cases have been described in children [15][16][17][18]. The coexistence of AP and SARS-CoV-2 infection causes increased systemic inflammatory response, contributed to the worsening of the patient's clinical state.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Infection as a Cause of Acute Pancreatitis in a Child—A Case Report

et al. 2021

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The novel coronavirus disease (COVID-19) was detected for the first time in China in December 2019. Soon after it was declared a pandemic. Main symptoms include fever, dyspnea, cough, muscle pain, headache, anosmia and ageusia, however a growing body of evidence shows that other organs can be affected. Gastrointestinal manifestations have been observed in a considerable number of patients and include abdominal pain, diarrhea and vomiting. The involvement of liver as well as pancreas has been also described, however there are only a few cases of acute pancreatitis reported in patients with COVID-19. Therefore, we present a case of 6-year-old child with mild acute pancreatitis and COVID-19 pneumonia.

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“…Nevertheless, Bansal et al [ 66 ] found that serum amylase or lipase did not correlate with the severity of COVID-19 or its mortality; and the prevalence of hyperamylasemia in patients with COVID-19 was 33%, while that of elevated lipase was 24.1%. Additionally, Suchman et al [ 60 ] showed that pancreatitis may occur in pediatric patients with COVID-19. Based on the above-mentioned studies, more research may be needed to investigate whether more elevated amylase and lipase levels are associated with a more severe course of this specific virosis.…”

Section: Digestive System Manifestations In Covid-19 Patientsmentioning

confidence: 99%

COVID-19 and the digestive system: A comprehensive review

Wang¹,

Yue²,

Cai³

et al. 2021

WJCC

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The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is spreading at an alarming rate, and it has created an unprecedented health emergency threatening tens of millions of people worldwide. Previous studies have indicated that SARS-CoV-2 ribonucleic acid could be detected in the feces of patients even after smear-negative respiratory samples. However, demonstration of confirmed fecal-oral transmission has been difficult. Clinical studies have shown an incidence rate of gastrointestinal (GI) symptoms ranging from 2% to 79.1% in patients with COVID-19. They may precede or accompany respiratory symptoms. The most common GI symptoms included nausea, diarrhea, and abdominal pain. In addition, some patients also had liver injury, pancreatic damage, and even acute mesenteric ischemia/thrombosis. Although the incidence rates reported in different centers were quite different, the digestive system was the clinical component of the COVID-19 section. Studies have shown that angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, was not only expressed in the lungs, but also in the upper esophagus, small intestine, liver, and colon. The possible mechanism of GI symptoms in COVID-19 patients may include direct viral invasion into target cells, dysregulation of angiotensin-converting enzyme 2, immune-mediated tissue injury, and gut dysbiosis caused by microbiota. Additionally, numerous experiences, guidelines, recommendations, and position statements were published or released by different organizations and societies worldwide to optimize the management practice of outpatients, inpatients, and endoscopy in the era of COVID-19. In this review, based on our previous work and relevant literature, we mainly discuss potential fecal-oral transmission, GI manifestations, abdominal imaging findings, relevant pathophysiological mechanisms, and infection control and prevention measures in the time of COVID-19.

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Acute pancreatitis in children hospitalized with COVID-19

Cited by 29 publications

References 8 publications

Acute Pancreatitis in COVID-19-associated Multisystem Inflammatory Syndrome of Children—A Single Center Experience

Acute Pancreatitis in COVID-19-associated Multisystem Inflammatory Syndrome of Children—A Single Center Experience

SARS-CoV-2 Infection as a Cause of Acute Pancreatitis in a Child—A Case Report

COVID-19 and the digestive system: A comprehensive review

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