Acute pancreatitis following oesophagogastroduodenoscopy.

Nwafo, Nnamdi

doi:10.1136/bcr-2017-222272

Cited by 6 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pancreatitis post gastroscopy is not a well-documented side effect [6][7][8]. In addition to this case there are only five documented cases of pancreatitis post gastroscopy without ampullary cannulation [3,[5][6][7][8] and only three cases post colonoscopy [7,9,10].…”

Section: Discussionmentioning

confidence: 85%

Gastroscopy-Induced Pancreatitis: A Rare Cause of Post-Procedure Abdominal Pain

Fadaee¹,

Clercq²

2019

J Med Cases

View full text Add to dashboard Cite

A 52-year-old man presented to the emergency department a few hours post gastroscopy with biopsies of the second part of the duodenum (D2) and colonoscopy with severe acute abdominal pain. On examination he had peri-umbilical tenderness. Subsequent laboratory and biochemical investigations revealed acute pancreatitis. The patient went on to develop complications of acute pancreatitis including bilateral pleural effusions and ascites. He was managed conservatively and was discharged home on day 16 of admission with a plan for elective laparoscopic cholecystectomy in the future.

show abstract

Section: Discussionmentioning

confidence: 85%

Gastroscopy-Induced Pancreatitis: A Rare Cause of Post-Procedure Abdominal Pain

Fadaee¹,

Clercq²

2019

J Med Cases

View full text Add to dashboard Cite

show abstract

“…Also, administration of L-arginine augmented the MPO activity to 8 folds as compared to the control group, while administration of mito-TEMPO caused a significant drop in MPO by 87% as compared to the L-arginine group. This is exemplified in the table (2).…”

Section: Effect Of Mito-tempo On Oxidative Stress Biomarkersmentioning

confidence: 87%

“…Moreover, L-arginine injection caused a notable significant rise in NOx content which was 39% as compared to the control group, while, administration of mito-TEMPO diminished the NOx content significantly by 40% as compared to the L-arginine group. This is illustrated in the table (2). In addition, injection of L-arginine produced a high increment in MDA content that was 48% as compared to the control group, however, administration of mito-TEMPO caused a prominent decline in MDA content that was 33% as compared to the l-arginine group.…”

Section: Effect Of Mito-tempo On Oxidative Stress Biomarkersmentioning

confidence: 88%

“…Acute pancreatitis (AP) is an acute pancreatic inflammatory process that sometimes includes peri-pancreatic tissues and even remote organ systems 1 . It is clinically characterized by abdominal pain and elevated blood pancreatic enzyme levels 2 . The severity of the disease ranges greatly from mild types that affect the pancreas only to significant multi-systemic organ failure disease and death 3 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mito-TEMPO improved L-Arginine- induced acute pancreatitis in rats via TLR-4/ NF-кB/ NLRP3 inflammasome downregulation and antioxidant properties

Fawzy

Fikry

Fawzy

et al. 2021

Azhar International Journal of Pharmaceutical and Medical Scien

View full text Add to dashboard Cite

Background: Acute pancreatitis (AP) is a globally significant disease with increasing incidence and prevalence especially in the western world. It has severe complications such as pseudocyst, infection, renal failure, breathing problems, diabetes, malnutrition and chronic pancreatitis. Chronic pancreatitis can lead to pancreatic cancer which is one of the worst types of cancer. Up till now, there is no licensed specific treatment for AP. Objective: This study investigated the therapeutic effects of Mito-TEMPO in the treatment of L-Arginine induced acute pancreatitis in rats besides a possible involved mechanistic pathway. Materials and Methods: Rats randomly allocated into 3 groups: (1) control (received normal saline), (2) L-Arginine treated (300mg/100gm, i.p once) & (3) L-Arginine+Mito-TEMPO treated (0.7mg/kg/ day, i.p for 7 days). After 7 days from AP induction, serum amylase & lipase, pancreatic inflammatory mediators "toll-like receptor-4 (TLR-4), nuclear factor kappa-B (NF-кB), NLRP3 inflammasome, caspase-1, interleukin-1 beta (IL-1B)", oxidative parameters "malondialdehyde (MDA), myeloperoxidase (MPO), nitric oxide (NO), reduced glutathione (GSH)", an apoptotic marker "caspase-3" & pancreatic histopathological changes were estimated for all rats.Results: L-Arginine induced AP was evidenced by elevation of serum amylase & lipase, pancreatic inflammatory mediators "TLR-4, NF-кB, NLRP3 inflammasome, caspase-1, IL-1B", oxidative parameters "MDA, MPO, NO", the apoptotic marker "caspase-3" and infiltration of inflammatory cells proved through hematoxylin & eosin stain alongside with the reduction of GSH content. All these harmful effects were improved significantly after the administration of Mito-TEMPO. Conclusion: Mito-TEMPO can be introduced as a new therapy for the treatment of acute pancreatitis due to its anti-inflammatory and antioxidant effects.

show abstract

“…Adverse effects of esophagogastroduodenoscopy include infections, bleedings or perforations [47,48], acute pancreatitis (direct trauma/gas insufflation) [49]; cardiopulmonary events Non relevant topic/ title, commentary, review articles, duplicates 1209…”

Section: Discussionmentioning

confidence: 99%

Is Routine Preoperative Esophagogastroduodenoscopy Prior to Bariatric Surgery Mandatory? Systematic Review and Meta-analysis of 10,685 Patients

et al. 2020

View full text Add to dashboard Cite

Background This systematic review and meta-analysis searched, retrieved and synthesized the evidence as to whether preoperative esophagogastroduodenoscopy (p-EGD) should be routine before bariatric surgery (BS). Methods Databases searched for retrospective, prospective, and randomized (RCT) or quasi-RCT studies (01 January 2000–30 April 2019) of outcomes of routine p-EGD before BS. STROBE checklist assessed the quality of the studies. P-EGD findings were categorized: Group 0 (no abnormal findings); Group 1 (abnormal findings that do not necessitate changing the surgical approach or postponing surgery); Group 2 (abnormal findings that change the surgical approach or postpone surgery); and Group 3 (findings that signify absolute contraindications to surgery). We assessed data heterogeneity and publication bias. Random effect model was used. Results Twenty-five eligible studies were included (10,685 patients). Studies were heterogeneous, and there was publication bias. Group 0 comprised 5424 patients (56%, 95% CI: 45–67%); Group 1, 2064 patients (26%, 95% CI: 23–50%); Group 2, 1351 patients (16%, 95% CI: 11–21%); and Group 3 included 31 patients (0.4%, 95% CI: 0–1%). Conclusion For 82% of patients, routine p-EGD did not change surgical plan/ postpone surgery. For 16% of patients, p-EGD findings necessitated changing the surgical approach/ postponing surgery, but the proportion of postponements due to medical treatment of H Pylori as opposed to “necessary” substantial change in surgical approach is unclear. For 0.4% patients, p-EGD findings signified absolute contraindication to surgery. These findings invite a revisit to whether p-EGD should be routine before BS, and whether it is judicious to expose many obese patients to an invasive procedure that has potential risk and insufficient evidence of effectiveness. Further justification is required.

show abstract

Acute pancreatitis following oesophagogastroduodenoscopy.

Cited by 6 publications

References 31 publications

Gastroscopy-Induced Pancreatitis: A Rare Cause of Post-Procedure Abdominal Pain

Gastroscopy-Induced Pancreatitis: A Rare Cause of Post-Procedure Abdominal Pain

Mito-TEMPO improved L-Arginine- induced acute pancreatitis in rats via TLR-4/ NF-кB/ NLRP3 inflammasome downregulation and antioxidant properties

Is Routine Preoperative Esophagogastroduodenoscopy Prior to Bariatric Surgery Mandatory? Systematic Review and Meta-analysis of 10,685 Patients

Contact Info

Product

Resources

About