Acute Pancreatitis – Etiology, Pathogenesis, Pathophysiology and The Current Trend in Its Management and Prevention

Derrick, Derrick; Frandy, Frandy; Wirawan, Antonius Dian

doi:10.24871/201201927-37

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Pernyataan tersebut sesuai dengan hasil penelitian ini yang menemukan peningkatan ALT (25%) serta hipoproteinemia dan hipoalbuminemia (15% dan 20%). AP dapat menimbulkan inflamasi sistemik yang disebabkan oleh adanya aktivasi enzim protease yang kemudian masuk ke pembuluh darah dan menyebabkan kerusakan endotel disertai dengan trombosis mikrovaskular sehingga terjadi multi-organ dysfunction syndrome (MODS) (Derrick et al, 2019). MODS dapat menimbulkan hipovolemia, hipotensi, hiperkoagulabilitas, dan deposisi fibrin di glomeruli yang kemudian dapat mengakibatkan terjadinya acute kidney injury (AKI) (Mansfield, 2012).…”

Section: Pembahasanunclassified

Analisis Serum Symmetric Dimethylarginine dalam Berbagai Gejala Klinis pada Anjing

Sulistiawati,

Zulfitra Utami Putri,

Cucu K. Sajuthi

2023

Acta Vet Indones

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Symmetric dimethylarginine (SDMA) merupakan golden standard untuk menilai fungsi ginjal terutama terkait glomerular filtration rate (GFR). Nilai SDMA pada serum dapat digunakan untuk mendeteksi Chronic Kidney Disease (CKD) sebelum kreatinin mengalami peningkatan diatas nilai normal pada anjing. Nilai SDMA telah dibuktikan sebagai pendeteksi awal kondisi penyakit ginjal, namun belum banyak data yang menjelaskan tentang adanya peningkatan nilai SDMA terkait gejala klinis lain selain penyakit ginjal. Penelitian ini bertujuan untuk mendapatkan informasi penyebab peningkatan nilai SDMA dengan proses penyebab peningkatan nilai SDMA terkait dengan gejala klinis yang timbul pada anjing selain gangguan ginjal. Penelitian dilakukan pada 20 ekor anjing dengan berbagai gejala klinis yang dilengkapi dengan data jenis kelamin, usia, dan pemeriksaan parameter kimia darah (BUN, kreatinin, ALT, total protein, albumin) dan SDMA. Nilai SDMA dianalisis dari sampel serum dengan menggunakan IDEXX Catalyst® SDMA Test. Hasil penelitian manunjukkan anjing yang mengalami gejala klinis terkait gangguan sistem urinari (60%) memiliki persentase tertinggi diikuti oleh gejala klinis terkait gangguan sistem pencernaan (45%), gangguan jantung (20%), gangguan mata dan gangguan periodontal (15%), gangguan otot dan tulang (10%), dan gangguan kulit (5%). Berdasarkan hasil tersebut dapat disimpulkan bahwa peningkatan nilai SDMA juga dapat terjadi pada berbagai gangguan fungsi organ dengan gejala klinis yang tidak spesifik menunjukkan gangguan fungsi ginjal.

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Section: Pembahasanunclassified

Analisis Serum Symmetric Dimethylarginine dalam Berbagai Gejala Klinis pada Anjing

Sulistiawati,

Zulfitra Utami Putri,

Cucu K. Sajuthi

2023

Acta Vet Indones

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Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis

Nalisa¹,

Nweke²,

Omoshoro-Jones³

et al. 2021

WJGP

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BACKGROUND Acute pancreatitis (AP) is an inflammatory disease, which presents with epigastric pain and is clinically diagnosed by amylase and lipase three times the upper limit of normal. The 2012 Atlanta classification stratifies the severity of AP as one of three risk categories namely, mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP). Challenges in stratifying AP upon diagnosis suggest that a better understanding of the underlying complex pathophysiology may be beneficial. AIM To identify the role of the chemokine receptor 8 ( CCR8 ), expressed by T-helper type-2 Lymphocytes and peritoneal macrophages, and its possible association to Interleukin (IL)-6 and AP stratification. METHODS This study was a prospective case-control study. A total of 40 patients were recruited from the Chris Hani Baragwanath Academic Hospital and the Charlotte Maxeke Johannesburg Academic Hospital. Bioassays were performed on 29 patients (14 MAP, 11 MSAP, and 4 SAP) and 6 healthy controls as part of a preliminary study. A total of 12 mL of blood samples were collected at Day (D) 1, 3, 5, and 7 post epigastric pain. Using multiplex immunoassay panels, real-time polymerase chain reaction (qRT-PCR) arrays, and multicolour flow cytometry analysis, immune response-related proteins, genes, and cells were profiled respectively. GraphPad Prism™ software and fold change (FC) analysis was used to determine differences between the groups. P <0.05 was considered significant. RESULTS The concentration of IL-6 was significantly different at D3 post epigastric pain in both the MAP group and MSAP group with P = 0.001 and P = 0.013 respectively, in a multiplex assay. When a FC of 2 was applied to identify differentially expressed genes using RT 2 Profiler, CCR8 was shown to increase steadily with disease severity from MAP (1.33), MSAP (38.28) to SAP (1172.45) median FC. Further verification studies using RT-PCR showed fold change increases of CCR8 in MSAP and SAP ranging from 1000 to 1000000 times when represented as Log 10 , compared to healthy control respectively at D3. The findings also showed differing lymphocyte and monocyte cell frequency between the groups. With monocyte population frequency as high as 70% in MSAP at D3. CONCLUSION The higher levels of CCR8 and IL-6 in the severe patients and immune cell differences compared to MAP and controls provide an avenue for exploring AP stratification to improve management.

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Acute Pancreatitis – Etiology, Pathogenesis, Pathophysiology and The Current Trend in Its Management and Prevention

Cited by 2 publications

References 3 publications

Analisis Serum Symmetric Dimethylarginine dalam Berbagai Gejala Klinis pada Anjing

Analisis Serum Symmetric Dimethylarginine dalam Berbagai Gejala Klinis pada Anjing

Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis

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