Acute pancreatitis during oral 5-aminosalicylic acid therapy

Fiorentini, Marta; Fracchia, M.; Galatola, G.; Barlotta, A.; Pierre, Marco De La

doi:10.1007/bf01537594

Cited by 62 publications

(25 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Few cases of steroid-induced pancreatitis have been reported since then. Someauthors put forward the hypothesis that a correlation between acute pancreatitis and 5-ASA therapy might exist (16)(17)(18)(19)(20)(21). The commoncharacteristics of 5-ASA-induced pancreatitis are as follows: mild symptoms,onset within three weeks after taking 5-ASA, no abnormal findings in the imaging examinations, no reports which referred to the pathological findings.…”

Section: Discussionmentioning

confidence: 99%

Pseudotumorous Pancreatitis Associated with Ulcerative Colitis.

et al. 2001

View full text Add to dashboard Cite

Pancreatitis is believed to be one of the uncommon extraintestinal manifestations of ulcerative colitis (UC). A 66-year-old womanwho had been treated for UCfor eight months was admitted to our hospital because of epigastralgia. Laboratory examinations revealed elevated pancreatic enzymes. Because differentiation of pseudotumorous pancreatitis from pancreatic cancer was difficult by the imaging findings, she underwent a distal pancreatectomy. Histologically, the tumorous lesion was composed of fibrosis with lymphocytic infiltration. Weconcluded that this case was pseudotumorouspancreatitis as an extraintestinal manifestation of UC.

show abstract

Section: Discussionmentioning

confidence: 99%

Pseudotumorous Pancreatitis Associated with Ulcerative Colitis.

et al. 2001

View full text Add to dashboard Cite

show abstract

“…It is therefore postulated that systemic absorption might occasionally occur for 5-ASA in high doses, and therefore could possibly cause toxicity in the pancreas [15]. On the other hand, even low blood levels of salicylate may be involved in acute pancreatitis in individual subjects in the setting of a hypersensitivity reaction, similar to Reye's syndrome [14]. In the present case, no information on the drug serum concentration was available.…”

Section: Discussionmentioning

confidence: 89%

“…The proposed pathogenic mechanism is increased permeability of the pancreatic duct due to the direct effect of salicylic acid [14]. Although there is a chemical similarity between 5-aminosalicylic acid (5-ASA) and salicylic acid, the former should not directly stimulate the pancreatic ducts, since it is delivered as an active drug only in the terminal ileum and colon.…”

Section: Discussionmentioning

confidence: 99%

Acute Pancreatitis due to pH-Dependent Mesalazine That Occurred in the Course of Ulcerative Colitis

Arai

Arihiro²,

Ichikawa³

et al. 2011

Case Rep Gastroenterol

View full text Add to dashboard Cite

We report the case of a 26-year-old male who presented with acute pancreatitis during the course of treatment for pancolitic ulcerative colitis (UC) with a time-dependent mesalazine formulation, prednisolone and azathioprine (AZA). Despite a review of his clinical history and various tests, the cause of pancreatitis could not be determined. Since drug-induced pancreatitis was considered possible, administration of the time-dependent mesalazine preparation and AZA was discontinued, and conservative treatment for acute pancreatitis was performed. The pancreatitis promptly improved with these treatments, but drug lymphocyte stimulation test (DLST) for both the time-dependent mesalazine formulation and AZA was negative. A pH-dependent mesalazine formulation was given for maintenance therapy of UC. Subsequently, as the pancreatitis relapsed, drug-induced pancreatitis was strongly suspected. Administration of mesalazine was discontinued, and pancreatitis was smoothly in remission by conservative treatment. According to the positive DLST result for the pH-dependent mesalazine formulation and the clinical course, a diagnosis of pH-dependent mesalazine-induced pancreatitis due to this formulation was made. During the clinical course of UC, occurrence of drug-induced pancreatitis must always be considered.

show abstract

“…and had recur rent pancreatitis when rechallenged twice with 5-aminosalicylic acid [215]. Eight addi tional patients developed pancreatitis during treatment with 5-aminosalicylic acid for Crohn's disease [216][217][218][219] or ulcerative coli tis [220]. All but 1 patient had positive re challenge.…”

Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Drug-Induced Acute Pancreatitis: Further Criticism

Frick¹,

Speiser²,

Bimmler³

et al. 1993

Dig Dis

View full text Add to dashboard Cite

A comprehensive literature search was performed to collect all available data on drug-induced pancreatitis. Strong evidence for an association with acute pancreatitis has been described for anticholinesterases, calcium 2’,3’-dideoxyinosine, estrogen, L-asparaginase, salicylates, thiazide-diuretics, valproic acid, and vinca alkaloids. Weak evidence has been found for antituberculous agents, azathioprine, biguanides, cisplatinum, cyclosporine A, H2-blocking agents, loop diuretics, 6-mercaptopurine, metronidazole, pentamidine, steroids, sulfonamides, sulindac and tetracycline. Many cases were associated with underlying conditions known to induce acute pancreatitis themselves. It is concluded that for none of the drugs studied the available data are consistent enough to support a definite association with acute pancreatitis. Nevertheless, the data suggest that drugs may be a trigger or a cofactor in inducing pancreatitis.

show abstract

Acute pancreatitis during oral 5-aminosalicylic acid therapy

Cited by 62 publications

References 14 publications

Pseudotumorous Pancreatitis Associated with Ulcerative Colitis.

Pseudotumorous Pancreatitis Associated with Ulcerative Colitis.

Acute Pancreatitis due to pH-Dependent Mesalazine That Occurred in the Course of Ulcerative Colitis

Drug-Induced Acute Pancreatitis: Further Criticism

Contact Info

Product

Resources

About