Acute pancreatitis caused by leptospirosis: Report of two cases

Kaya, Ekrem; Dervişoğlu, Adem; Eroğlu, Cafer; Polat, Cafer; Sünbül, Mustafa; Özkan, Kayhan

doi:10.3748/wjg.v11.i28.4447

Cited by 35 publications

(30 citation statements)

References 13 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In most series published in the English literature, gallstones are the leading cause, followed by alcohol. Although the reported figures vary, the frequencies of metabolic and infectious causes in the present series are higher than those reported [4,8,11,12] . Idiopathic AP includes cases with unelucidated etiology.…”

Section: Discussioncontrasting

confidence: 54%

Evaluation of diagnostic findings and scoring systems in outcome prediction in acute pancreatitis

Kaya¹,

Dervişoğlu²,

Polat³

2007

WJG

Self Cite

View full text Add to dashboard Cite

AIM:To determine factors related to disease severity, mortality and morbidity in acute pancreatitis. METHODS:One hundred and ninety-nine consecutive patients were admitted with the diagnosis of acute pancreatitis (AP) in a 5-year period (1998)(1999)(2000)(2001)(2002). In a prospective design, demographic data, etiology, mean hospital admission time, clinical, radiological, biochemical findings, treatment modalities, mortality and morbidity were recorded. Endocrine insufficiency was investigated with oral glucose tolerance test. The relations between these parameters, scoring systems (Ranson, Imrie and APACHE Ⅱ) and patients' outcome were determined by using invariable tests and the receiver operating characteristics curve.

show abstract

Section: Discussioncontrasting

confidence: 54%

Evaluation of diagnostic findings and scoring systems in outcome prediction in acute pancreatitis

Kaya¹,

Dervişoğlu²,

Polat³

2007

WJG

Self Cite

View full text Add to dashboard Cite

show abstract

“…2 Pancreatitis is described as an uncommon complication of leptospirosis, but there are a considerable number of reports in literature. [37][38][39][40] In the present study, the complications found were pulmonary bleeding (14%), tract intestinal bleeding (13%), atrial fibrillation (11.4%), pulmonary infection (6.0%), meningitis (1.0%) and pancreatitis (0.5%).…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation of leptospirosis: a retrospective study of 201 patients in a metropolitan city of Brazil

Daher¹,

Lima²,

Júnior³

et al. 2010

Braz J Infect Dis

View full text Add to dashboard Cite

INTRODUCTION: leptospirosis is a zoonosis of worldwide importance. The disease is endemic in Brazil. This study was conducted to describe the clinical and laboratory presentation of leptospirosis in a metropolitan city of Brazil. METHODS: this is a retrospective study including 201 consecutive patients with leptospirosis admitted to tertiary hospitals in Fortaleza, Brazil, between 1985 and 2006. All patients had clinical and epidemiological data suggestive of leptospirosis, and positive laboratorial test for leptospirosis (microscopic agglutination test, MAT, higher than 1:800). RESULTS: a total of 201 patients were included, with mean age of 38.9 ± 15.7 years; 79.1% were male. The mean length from onset of symptoms to admission was 7 ± 3 days. The main clinical signs and symptoms at admission were fever (96.5%), jaundice (94.5%), myalgia (92.5%), headache (74.6%), vomiting (71.6%) and dehydration (63.5%). Hemorrhagic manifestations were present in 35.8%. Acute kidney injury was found in 87% of the patients. Platelet count was less than 100,000/mm³ in 74.3%. Hematuria was found in 42.9%. Death occurred in 31 cases (15.4%). CONCLUSIONS: leptospirosis is a globally relevant disease with potential fatal outcome. Signs and symptoms suggestive of leptospirosis must be known by any physician in order to institute early adequate treatment to improve outcome. Early indication and daily hemodialysis seems to be beneficial in this group of patients

show abstract

“…An immunological basis for pathogenesis of leptospirosis including Toll like receptor (TLR) 2 activation is described recently [12]. The most consistent pathologic finding in leptospirosis is vasculitis of capillaries manifested by endothelial oedema, necrosis and lymphocytic infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…The most consistent pathologic finding in leptospirosis is vasculitis of capillaries manifested by endothelial oedema, necrosis and lymphocytic infiltration. Small vessel vasculitis and ischemic injury leading to activation of proteolytic enzymes and auto-digestion is a possible mechanism [12]. All the patients described in the current series, were hemodynamicaly unstable at presentation or within the first 24 h of hospital stay.…”

Section: Discussionmentioning

confidence: 99%

Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka

2016

View full text Add to dashboard Cite

BackgroundAcute pancreatitis is identified as an atypical and rare presentation of leptospirosis. In this report, we discuss a case series of severe leptospirosis with pancreatitis as a main complication during an unusual outbreak of leptospirosis in Anuradhapura district, Sri Lanka.Case presentationWe retrospectively reviewed clinical presentation, investigations, treatment and outcome of six confirmed cases of severe leptospirosis admitted to intensive care unit (ICU) of Teaching Hospital, Anuradhapura, within a three months period from November 2014 to January 2015.All six patients were previously healthy paddy farmers presented with fever, myalgia and arthralgia. Four patients had abdominal pain, nausea and vomiting on admission. Hypotension, Neutrophilic leukocytosis and thrombocytopaenia was detected in all patients in the initial stage. Four patients had serum amylase more than 900 (range 941–2420). All patients had acute kidney injury and hepatitis. Significantly elevated amylase and low serum calcium were present in 4 cases. Five patients recovered without any evidence of residual organ damage, but one succumbed to the illness.ConclusionThis case series emphasizes the importance of identification of acute pancreatitis as a common complication of Leptospirosis, in order to reduce mortality and morbidity.

show abstract

Acute pancreatitis caused by leptospirosis: Report of two cases

Cited by 35 publications

References 13 publications

Evaluation of diagnostic findings and scoring systems in outcome prediction in acute pancreatitis

Evaluation of diagnostic findings and scoring systems in outcome prediction in acute pancreatitis

Clinical presentation of leptospirosis: a retrospective study of 201 patients in a metropolitan city of Brazil

Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka

Contact Info

Product

Resources

About