Acute pancreatitis associated with hypercalcaemia

Role of IL-10 gene polymorphisms in the development of acute pancreatitis

“…Acute pancreatitis is a complex disease, and the accurate mechanisms underlying its development are not well understood. It has been suggested that many lifestyle choices and environmental factors such as excessive drinking, pancreatic duct strictures, viral or bacterial infection, hyperlipidemia, metabolic disorders, and infections are associated with disease susceptibility (Álvarez et al, 2015;Greer et al, 2015;Pohl and Uc, 2015;Talukdar and Vege, 2015;Tun-Abraham et al, 2015). Recent studies have reported that genetic factors play an important role in the pathogenesis of acute pancreatitis, such as interleukin-1β (IL-1β), IL-8, IL-10, heme oxygenase-1 gene, Toll-like receptor gene, tumor necrosis factor alpha gene, and heat-shock protein 70-2 gene (Özhan et al, 2010;Bishehsari et al, 2012;Srivastava et al, 2012;Gulla et al, 2014;Li et al, 2015;Matas-Cobos et al, 2015).…”

Giant Parathroid Adenoma With Thoracic Extension: A Case Report

“…This association is reported in <10% of cases in the literature. 6 Krishnamurthy reported the same circumstance of discovery in a patient presenting recurrent episodes of acute pancreatitis. 4 Blood tests showed, in our case, hypercalcemia with high level of PTH confirming the diagnosis of a primary hyperparathyroidism.…”

A Rare Case of Solitary Parathyroid Adenoma presenting with Recurrent Pancreatitis detected by Dual-phase Single-isotope Imaging (Technetium Sestamibi and Technetium Thyroid Scan) with SPECT-CT

“…The incidence of acute pancreatitis associated with hyperparathyroidism is reported to be <10%. 4,5 According to existing literature, the association between pancreatitis and primary hyperparathyroidism appears to be rather uncommon. The likely mechanism of hyperparathyroidism leading to acute pancreatitis is that hypercalcemia may cause activation of trypsinogen to trypsin, resulting in autodigestion of the pancreas.…”