Acute pancreatitis associated with herpes simplex virus infection: report of a case and review of the literature

Konstantinou, George N.; Liatsos, Christos; Patelaros, Emmanuel G.; Karagiannis, Stephanos; Karnesis, Lazaros; Mavrogiannis, Christos

doi:10.1097/meg.0b013e3283005890

Cited by 17 publications

(8 citation statements)

References 9 publications

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“…As shown in Table , no islet sample tested positive for any herpes virus, despite several animals testing positive in the PBMC for herpes viruses, ranging from 2.9% for PLHV2 to 38.1% for PLHV3. In humans, cases of acute pancreatitis associated with herpes viruses such as CMV, varicella zoster virus (VZV) and herpes simplex virus (HSV) do occur but are rare, although the cell type affected within the pancreas is not known. However, several reports have examined CMV in immunosuppressed CMV‐negative patients receiving islet allografts from CMV‐positive donors and found a complete absence of CMV transmission in all recipients (n = 12 and n = 4) supporting our data that islet cells do not commonly harbour herpes viruses.…”

Section: Resultsmentioning

confidence: 99%

Examining the potential for porcine‐derived islet cells to harbour viral pathogens

Crossan

O'Hara

Mourad

et al. 2017

Xenotransplantation

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With an onus on safety in the potential use of porcine islet cells as a treatment for diabetes, the use of animals lacking exogenous pathogens is clearly important and multilevel screening strategies have been presented on testing animals and the product. In this study, we wished to investigate whether islet cells indeed harboured the same viral pathogens of concern in the source animal. PMBC and islet cells from both adult and neonatal source animals were directly compared and tested for PCMV, PLHV, PCV2, PPV and HEV using both molecular and serological assays. Adult PBMC were found positive for all viruses with the exception of PCV2 and HEV. Neonatal PBMC were only found positive for PCMV and HEV. All animals were found negative for HEV antibodies. Interestingly, islet cells were negative for all viruses tested regardless of status in the animal-derived PBMC. Given that other laboratories have demonstrated the lack of virus detection during the culture of islets, this study also demonstrates that the hygiene status of the herd may not reflect the status of the product. This is important for establishing guidelines for any risk evaluation and mitigation process utilised during product manufacture.

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Section: Resultsmentioning

confidence: 99%

Examining the potential for porcine‐derived islet cells to harbour viral pathogens

Crossan

O'Hara

Mourad

et al. 2017

Xenotransplantation

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“…There have been sporadic reports of HSV causing AP [23]. One particular case report was disseminated HSV causing AP.…”

Section: Viral Causes Of Apmentioning

confidence: 99%

Review of Infectious Etiology of Acute Pancreatitis

2017

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While gallstones and alcoholism are widely known to be the most common causative agents of acute pancreatitis, about 10% of cases are thought to be caused by infectious microorganisms. These microorganisms include viruses (e.g. mumps, Coxsackie B, and hepatitis), bacteria (e.g. Mycoplasma pneumoniae and leptospirosis), and parasites (e.g. Ascaris lumbricoides, Fasciola hepatica, and hydatid disease). Each organism causes acute pancreatitis through diverse mechanisms. The review is primarily conducted in an attempt to provide a better understanding of the possibility of acute pancreatitis presenting as a complication relating to these organisms, and the aim is to guide future diagnoses, management, and predictions of complications.

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“…In all these subjects, clinical manifestations of pancreatitis or cholecystitis were synchronous with those of EBV infection. Viral AP related to herpes virus or cytomegalovirus (CMV) infection [117,118] is common in immunocompromised individuals. CMV infection-related pancreatitis/hepatitis should, therefore, be considered in the diagnostic work-up of immunocompetent patients [119], especially when a recent viral-like illness is reported.…”

Section: Viral Infectionsmentioning

confidence: 99%

Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up

Blanco

Gesuale

Varanese

et al. 2019

Clin J Gastroenterol

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Acute pancreatitis (AP) is a common disease associated with a substantial medical and financial burden, and with an incidence across Europe ranging from 4.6 to 100 per 100,000 population. Although most cases of AP are caused by gallstones or alcohol abuse, several other causes may be responsible for acute inflammation of the pancreatic gland. Correctly diagnosing AP etiology is a crucial step in the diagnostic and therapeutic work-up of patients to prescribe the most appropriate therapy and to prevent recurrent attacks leading to the development of chronic pancreatitis. Despite the improvement of diagnostic technologies, and the availability of endoscopic ultrasound and sophisticated radiological imaging techniques, the etiology of AP remains unclear in ~ 10-30% of patients and is defined as idiopathic AP (IAP). The present review aims to describe all the conditions underlying an initially diagnosed IAP and the investigations to consider during diagnostic work-up in patients with non-alcoholic non-biliary pancreatitis.

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Acute pancreatitis associated with herpes simplex virus infection: report of a case and review of the literature

Cited by 17 publications

References 9 publications

Examining the potential for porcine‐derived islet cells to harbour viral pathogens

Examining the potential for porcine‐derived islet cells to harbour viral pathogens

Review of Infectious Etiology of Acute Pancreatitis

Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up

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