Acute painless paraparesis due to bilateral femoral artery occlusion

Iyadurai, Stanley; Tsivgoulis, Georgios; Sharma, Vijay K.; Lao, Annabelle Y.; Alexandrov, Andrei V.

doi:10.1016/j.ejim.2007.02.024

Cited by 5 publications

(3 citation statements)

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“…Certain pathological conditions are responsible for the development of vasculatic neuropathy such as diabetes mellitus, vascular occlusive diseases, necrotizing vasculitides, peripheral arterial disease, trauma etc [14]. Moreover, peripheral vascular changes are common progressive factors for the acute and chronic ischemic neuropathic pain in patients [15].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological evaluation of tacrolimus (FK-506) on ischemia reperfusion induced vasculatic neuropathic pain in rats

Muthuraman

Sood

2014

J Brachial Plex Peripher Nerve Inj

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BackgroundIschemia reperfusion (I/R) is common in various pathological conditions like diabetic complication, rheumatic arthritis, necrotizing vascular occlusive disease and trauma.MethodsWe have evaluated the effect of tacrolimus (1, 2 and 3 mg/kg, p.o. for 10 consecutive days) on femoral arterial ischemic reperfusion (I/R) induced neuropathic pain in rats. Behavioral parameters (i.e. hot plate, radiant heat, acetone drop, tail heat hyperalgesia, tail flick and tail cold allodynia tests) were assessed at different time intervals (i.e. 0, 1, 4, 7, 10, 13 and 16th day) and biochemical analysis in serum and tissue samples were also performed along with histopathological studies.ResultsBehavioral pain assessment revealed increase in the paw and tail withdrawal threshold in tacrolimus treated groups against hyperalgesic and allodynic stimuli as compared to the sham control group. We observed a decrease in the serum nitrate and thiobarbituric acid reactive substance (TBARS) levels along with reduction in tissue myeloperoxidase (MPO) and total calcium levels, whereas, rise in tissue reduced glutathione levels in tacrolimus treated groups. However, significant results were obtained in medium and high dose treated group as compared to sham control group. Histopathological study had revealed the increase in the neuronal edema and axonal degeneration in the I/R group whereas, tacrolimus ameliorate these effects.ConclusionOur results indicate the anti-oxidative, anti-inflammatory and calcium modulatory actions of tacrolimus. Therefore, it can be used as a therapeutic agent for the treatment of vascular inflammatory related neuropathic pain.

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Section: Introductionmentioning

confidence: 99%

Pharmacological evaluation of tacrolimus (FK-506) on ischemia reperfusion induced vasculatic neuropathic pain in rats

Muthuraman

Sood

2014

J Brachial Plex Peripher Nerve Inj

View full text Add to dashboard Cite

show abstract

“…In our study, the peripheral nerve has been targeted for induction of vasculitic neuropathy in rats by the process of femoral artery ischemia-reperfusion. The event of femoral artery ischemiareperfusion process has been well documented for the induction of the neuro-inflammation, neuronal excitability and enhancement of pain sensation (Iyadurai et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Free radicals are also found to be involved in chronic constriction injury, tibial sural transection, axotomy, traumatic injury and peripheral ischemia-reperfusion induced neuropathic pain (Koban et al, 2003;Muthuraman et al, 2008a,b). Further, they cause neuronal and endothelial damage through the induction of lipid peroxidation and changes in vascular integrity (Honjo et al, 2002;Iyadurai et al, 2007;Nagamatsu et al, 1996). Excess of free radicals result in reduction of reduced glutathione level, leads to calcium overload.…”

Section: Discussionmentioning

confidence: 99%