Acute overdose of enteric-coated valproic acid and olanzapine: Unusual presentation and delayed toxicity

Pons, Sandrine; Gonzva, Jonathan; Prunet, Bertrand; Gaillard, Tiphaine; Brisou, P.; Vest, Philippe; Emile, Loïc

doi:10.3109/15563650.2012.657760

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…Intentional ingestion, often for suicidal purposes, or insufficient therapy monitoring and control, can result in poisoning with sodium valproate, as well as with phenytoin, commonly prescribed for antiepileptic treatment. Some reports suggest that an overdose of sodium valproate tablets may lead to delayed toxicity characterized by clinical symptoms arising when hyperammonemia develops [87].…”

Section: Effects Of Ile In Valproate Intoxicationsmentioning

confidence: 99%

Intravenous Lipid Emulsions in Anticonvulsants' Toxicity

Dimitrova,

Dragomanova,

Kehayova

2024

Preprint

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(1) Background: In recent years, an innovative approach has emerged in the field of toxicology for managing acute intoxications caused by lipophilic substances: intravenous lipid emulsions (ILE). Through numerous experiments and case reports, the efficacy of lipid emulsions in counteracting toxicities induced by lipophilic agents, including a significant number of antiepileptic drugs (AE), has become increasingly evident. (2) Methods: Data spanning a 10-year period (2010-2020) was analyzed by searching through multiple scientific publication platforms like PubMed, Science Direct, Research Gate, and Springer Link. The study focused on reviewing relevant case reports detailing successful Intravenous lipid emulsion (ILE) administration in pa-tients with acute intoxications with antiepileptics, specifically examining the impact of fat emul-sions on neurological status, Glasgow Coma Scale (GCS) scores, and corrected QT interval con-cerning hemodynamic instability. (3) Results: The typical symptoms of antiepileptic toxicity in-clude central nervous system depression, ataxia, and nystagmus. Intravenous lipid emulsion ap-plication resulted in an increase in Glasgow Coma Scale scores and enhanced recovery from drug intoxication. (4) Conclusions: This study provides a comprehensive overview of the potential utility of ILE as a component to antidote therapy in cases of acute AE poisoning involving neurotropic drugs. The process involves the engagement of various mechanisms of antitoxic activity.

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Section: Effects Of Ile In Valproate Intoxicationsmentioning

confidence: 99%

Intravenous Lipid Emulsions in Anticonvulsants' Toxicity

Dimitrova,

Dragomanova,

Kehayova

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Common drugs include anticholinergic, opioid agonists, anesthetics, and other sedatives. In the setting of overdose, absorption can continue longer than predicted by pharmacokinetics, especially for enteric coated or extended release medications, anticholinergics, and/or opioids [207][208][209][210][211][212][213][214][215][216][217][218][219].…”

Section: Delayed Absorptionmentioning

confidence: 99%