“…In addition, the agonistic effects of these botanical compounds on CB2R may helpexplain and understand their biological activities. Desmethoxyyangonin, dihydromethysticin, flavokawain A, and flavokawain C, as the major chemical constituents of Piper methysticum Forst., have exhibited significant anti-inflammatory, anti-cancer, and neuro-protective effects [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. 11-keto-β-boswellic acid is a triterpenoid found in Boswellia serrata and has potential therapeutic efficacy against several chronic inflammatory diseases and neurodegenerative diseases [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ].…”