Acute oral selenium intoxication with ten times the lethal dose resulting in deep gastric ulcer

Kise, Yoshifumi; Yoshimura, Satoshi; Akieda, Kazuki; Umezawa, Kazuo; Okada, Ken-ichi; Yoshitake, Noriyuki; Shiramizu, Hideki; Yamamoto, Ikuo; Inokuchi, Sadaki

doi:10.1016/j.jemermed.2003.07.002

Cited by 20 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The selenosis symptoms reported by the SSIS subjects generally parallel those reported in previously published studies of the TBF Se toxicity outbreak [61,62,63,64,65]; other reports of Se toxicity caused by misformulated supplements [18,19,20]; Se toxicity caused by over-indulgence in Brazil nuts [50,51,52,53,54]; and cases of environmental, occupational, accidental, suicidal, and homicidal Se poisoning [55,56,57,58,59,60,61]. However, a major difference is that these studies do not report long-term follow-up.…”

Section: Discussionsupporting

confidence: 86%

“…There have also been several reports covering serious injury and deaths from environmental, occupational, accidental, suicidal, and homicidal Se poisoning [55,56,57,58,59,60,61]. These reports provide important information on the severely acute symptoms associated with lethal Se poisoning and also on the corresponding Se concentrations found in body fluids and the most critically implicated tissues.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Selenium Toxicity from a Misformulated Dietary Supplement, Adverse Health Effects, and the Temporal Response in the Nail Biologic Monitor

Morris

Crane

2013

Nutrients

View full text Add to dashboard Cite

Use of dietary supplements in the U.S. has increased steadily over the last 25 years. While misformulation is uncommon, the consequences can be serious. A March 2008 voluntary market recall removed supplement products responsible for the most serious selenium toxicity outbreak that has occurred in the U.S. We quantified selenium concentrations in the misformulated supplement products, measured the temporal response in the nail biologic monitor, and associated exposure to self-reported selenosis symptoms. Subjects recruited through state health departments and referrals provided samples of the misformulated supplement products, exposure information, monthly toenail and or fingernail clippings or onycholysitic nail fragments, and listed their newly onset adverse health effects attributed to selenium toxicity. Ninety-seven subjects enrolled and submitted at least one test sample. Peak selenium concentrations (up to 18.3 and 44.1 μg/g for toenails and fingernails, respectively) were measured. Multiple samples (52 total) of all six recalled supplement lots were analyzed ranging from 22,300 to 32,200 μg selenium per daily dose. Average consumption was 30.9 ± 13.9 doses; 73 subjects provided follow-up data on selenosis symptoms at 2.50 ± 0.14 years. Nail samples accurately reflect exposure in this selenium toxicity outbreak, which resulted in long-term/permanent adverse health effects.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Selenium Toxicity from a Misformulated Dietary Supplement, Adverse Health Effects, and the Temporal Response in the Nail Biologic Monitor

Morris

Crane

2013

Nutrients

View full text Add to dashboard Cite

show abstract

“…Excessive doses of selenium result in intoxication, which is characterised by continuous vomiting, garlicky breath, mucosal irritation, abdominal pain, hypersalivation, haemolysis, necrosis of the liver, cerebral and pulmonary oedema, coma and death 3 , 8 . Selenium presents a nutritional conundrum because of its dual status as an essential but highly toxic trace element 9 …”

Section: Discussionmentioning

confidence: 99%

“…The exact mechanism of selenium toxicity is as yet unknown 8 , 10 . It has been suggested that the ready substitution of selenium for sulfur in biochemical reactions may inactivate the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, 10 contributing to the acute toxic effect.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Accidental death from acute selenium poisoning

See

Lavercombe

Dillon

et al. 2006

Medical Journal of Australia

View full text Add to dashboard Cite

Nutritional Disorders Affecting the Skin

Chu

Jen

Yan

2016

Rook's Textbook of Dermatology, Ninth Edition

View full text Add to dashboard Cite

Balanced intake, absorption and utilization of macro‐ and micronutrients, including carbohydrates, protein, fat, vitamins and minerals, are necessary for the function of various physiological processes and metabolic reactions. Derangements in this critical balance may lead to disease states with significant cutaneous and systemic manifestations. This chapter provides a comprehensive overview of various essential nutrients and their associated biological significance, as well as the important clinical syndromes that result from their deficiency or excess.

show abstract

Acute oral selenium intoxication with ten times the lethal dose resulting in deep gastric ulcer

Cited by 20 publications

References 23 publications

Selenium Toxicity from a Misformulated Dietary Supplement, Adverse Health Effects, and the Temporal Response in the Nail Biologic Monitor

Selenium Toxicity from a Misformulated Dietary Supplement, Adverse Health Effects, and the Temporal Response in the Nail Biologic Monitor

Accidental death from acute selenium poisoning

Nutritional Disorders Affecting the Skin

Contact Info

Product

Resources

About