Acute Optic Neuritis: Association With Paranasal Sinus Inflammatory Changes on Magnetic Resonance Imaging

Ergene, Erhan; Rupp, Frederick W.; Qualls, Clifford; Ford, Corey C.

doi:10.1111/jon2000104209

Cited by 17 publications

(7 citation statements)

References 24 publications

(7 reference statements)

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“…Some reports from western and Asian countries suggest that optic neuritis may be associated with sinusitis, mostly with sphenoid sinusitis 7,[13][14][15] . Most of our patients with MRI findings of sinusitis affected the maxillary or ethmoid sinuses.…”

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confidence: 99%

Etiological profile of presumptive optic neuritis in China

Zhang

Wang

Wei

et al. 2008

Journal of Clinical Neuroscience

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Objective: To determine the diagnoses in a population of patients with presumed optic neuritis in China and compare the spectrum of etiologies with those in western countries. Methods: We studied a group of 204 patients referred with a presumptive diagnosis of optic neuritis (ON) to a teaching hospital. We conducted detailed medical and family history, thorough ophthalmologic and neurological examinations, and laboratory tests including neuroimaging. Patients were diagnosed using international diagnostic criteria.Results: 113 cases (55.4%) met ON criteria, among which 83 cases (73.5%) were considered as idiopathic demyelinating optic neuritis (IDON). Brain MRI white matter lesions were found in 11 of 78 (14.1%) clinically "isolated" IDON cases. Tuberculosis meningitis accounted for 2 cases and syphilis for 1. The cause of 26 cases (23.0%) remained uncertain, but these cases were still likely to be IDON accompanied by secondary axonal degeneration. Thirty-eight cases (18.6%) were confirmed to be Leber's hereditary optic neuropathy Etiological profile of presumptive optic neuritis in China

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confidence: 99%

Etiological profile of presumptive optic neuritis in China

Zhang

Wang

Wei

et al. 2008

Journal of Clinical Neuroscience

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“…Ergene et al [2] compared the frequency of paranasal sinus inflammatory changes on magnetic resonance images obtained from 23 patients with ON and 48 control patients. The author found a higher frequency of paranasal sinus inflammatory changes in patients with ON (83%) than in controls (54%).…”

Section: Discussionmentioning

confidence: 99%

Optic neuritis and paranasal sinus diseases

et al. 2010

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AbstractThe relationship of sinusitis and paranasal sinus mucoceles to optic neuritis (ON) remains a challenge for both the otolaryngologist and the ophthalmologist. Currently, ON is assumed to be a rare complication of paranasal sinus diseases. Three new cases of ON associated with paranasal sinus diseases are described. We postulate different pathophysiologic mechanisms of ON in our three patients: compression of optic nerve due to sphenoid mucocele in the first patient; extension of bacterial infection to the optic nerve in the second patient; and invasion of aspergillosis to the orbital apex in the third patient. We assume that the complete recovery of the patient’s vision in the second case resulted from surgery, which had been performed immediately. A timely operation could possibly have prevented permanent blindness in cases 1 and 3 as well. Optic neuritis can occasionally be a complication of bacterial and mycotic sinusitis or paranasal sinus mucoceles, especially if located in the sphenoid sinus and posterior ethmoids. The evaluation of paranasal sinuses using imaging techniques is necessary to diagnose the problem, and immediate surgery can prevent permanent sequelae in indicated cases.

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“…Furthermore, chronic sinusitis is more common in MS and is significantly associated with the timing of relapses . Indeed, even in the very earliest stages of the disease MRI studies show that paranasal sinus inflammatory changes are significantly more common in cases of acute optic neuritis than in controls . Specifically, S. aureus is a leading cause of chronic sinusitis and has also been independently associated with MS.…”

Section: Nasal Cavitymentioning

confidence: 99%

Invited Review: From nose to gut – the role of the microbiome in neurological disease

Bell

Spencer

Yates

et al. 2018

Neuropathology Appl Neurobio

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Inflammation and neurodegeneration are key features of many chronic neurological diseases, yet the causative mechanisms underlying these processes are poorly understood. There has been mounting interest in the role of the human microbiome in modulating the inflammatory milieu of the central nervous system (CNS) in health and disease. To date, most research has focussed on a gut‐brain axis, with other mucosal surfaces being relatively neglected. We herein take the novel approach of comprehensively reviewing the roles of the microbiome across several key mucosal interfaces – the nose, mouth, lung and gut – in health and in Parkinson's disease (PD), Alzheimer's disease (AD) and multiple sclerosis (MS). This review systematically appraises the anatomical and microbiological landscape of each mucosal surface in health and disease before considering relevant mechanisms that may influence the initiation and progression of PD, AD and MS. The cumulative effects of dysbiosis from the nose to the gut may contribute significantly to neurological disease through a wide variety of mechanisms, including direct translocation of bacteria and their products, and modulation of systemic or CNS‐specific immunity. This remains an understudied and exciting area for future research and may lead to the development of therapeutic targets for chronic neurological disease.

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Acute Optic Neuritis: Association With Paranasal Sinus Inflammatory Changes on Magnetic Resonance Imaging

Cited by 17 publications

References 24 publications

Etiological profile of presumptive optic neuritis in China

Etiological profile of presumptive optic neuritis in China

Optic neuritis and paranasal sinus diseases

Invited Review: From nose to gut – the role of the microbiome in neurological disease

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