Acute-Onset Endophthalmitis after Clear Corneal Cataract Surgery (1996–2005)

Lalwani, Geeta A.; Flynn, Harry W.; Scott, Ingrid U.; Quinn, Carolyn M.; Berrocal, Audina M.; Davis, Janet L.; Murray, Timothy G.; Smiddy, William E.; Miller, Darlene

doi:10.1016/j.ophtha.2007.06.006

Cited by 190 publications

(88 citation statements)

References 10 publications

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“…Hypopyon is present in approximately 80% of the patients with biopsy-proven endophthalmitis after cataract surgery [12], in contrast to 20.5% in biopsy-proven endophthalmitis after anti-VEGF therapy seen in our data. An explanation may be that in endophthalmitis after anti-VEGF injection, the vitreous is the initially infected compartment, whereas the anterior chamber is contaminated first in postcataract endophthalmitis.…”

Section: Discussioncontrasting

confidence: 52%

“…Lalwani et al [12] reported a mean time of 13 days between cataract surgery and the diagnosis of endophthalmitis. Endophthalmitis after anti-VEGF injection occurs much more quickly.…”

Section: Discussionmentioning

confidence: 99%

“…Lalwani et al [12 ]found coagulase-negative Staphylococcus in 50 of 73 (68.4%) eyes. Other isolates included S. aureus in 5 of 73 (6.8%) and Streptococcus sp.…”

Section: Discussionmentioning

confidence: 99%

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Suspected Bacterial Endophthalmitis following Intravitreal Anti-VEGF Injection: Case Series and Literature Review

et al. 2012

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Aim: To report an up-to-date overview of all patients reported in the literature with suspected bacterial endophthalmitis following anti-VEGF injection. Secondly, to identify specific symptoms and signs to differentiate between infectious and noninfectious endophthalmitis. Methods: A Pubmed search retrieved 12 retrospective case series which had included a total of 118 patients with suspected bacterial endophthalmitis after anti-VEGF injection. Data of 15 patients from the Rotterdam Eye Hospital were added. Patients were divided into three groups: those who did not receive intravitreal antibiotics (group A), patients who received intravitreal antibiotics with biopsy-negative cultures (group B) and those with biopsy-positive cultures (group C). Results: The median time between anti-VEGF injection and presentation with suspected bacterial endophthalmitis was 1 day in group A compared to 3 days in groups B and C. At presentation, patients of group A had a better median visual acuity (logMAR 1.0) compared to those in groups B and C (logMAR 2.1 and 2.5, respectively). Conclusion: This study suggests that patients presenting with a visual acuity of 20/200 (logMAR 1.0) or less and later than 24 h after injection are more likely to have bacterial endophthalmitis. To prevent undertreatment in these patients, the threshold to proceed to vitreous biopsy and empirical intravitreous antibiotics should be low.

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Section: Discussioncontrasting

confidence: 52%

“…Lalwani et al [12] reported a mean time of 13 days between cataract surgery and the diagnosis of endophthalmitis. Endophthalmitis after anti-VEGF injection occurs much more quickly.…”

Section: Discussionmentioning

confidence: 99%

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Suspected Bacterial Endophthalmitis following Intravitreal Anti-VEGF Injection: Case Series and Literature Review

et al. 2012

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“…The EVS, conducted during 1991-1994, enrolled patients with scleral tunnel incisions. A follow-up retrospective study of patients recruited during 1996-2005 with clear corneal incisions reported generally similar outcomes compared with the EVS (Lalwani et al, 2008).…”

Section: Other Resultsmentioning

confidence: 90%

Endophthalmitis Following Cataract Surgery: Clinical Features, Treatment and Prophylaxis

Pathengay¹,

Schwartz²,

Flynn³

et al. 2013

Cataract Surgery

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“…However, transparent corneal incision use may still play a role in the occurrence of endophthalmitis under some circumstances. Nevertheless, it has been widely accepted that neither transparent corneal incisions nor scleral tunnel incisions increase the risk for endophthalmitis when incision size is within 3 mm (Lalwani et al, 2008). However, incisional leaks and poor healing may be risk factors for postoperative endophthalmitis (Chee et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Clinical features and treatment of endophthalmitis after cataract surgery

Zhu

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the clinical features and treatment results of endophthalmitis after cataract surgery. Five patients with endophthalmitis after phacoemulsification with intraocular lens implantation were enrolled in this study. The pathogenesis, clinical manifestation, and surgical outcomes of 5 patients were compared. Three patients were surgically treated with anterior chamber irrigation and vitrectomy with intravitreal injection. The remaining two patients were medically treated with an intravitreal injection of vancomycin and ceftazidime. Treatment results of the five patients were analyzed. Four patients had positive cultures for bacteria (two cases Staphylococcus epidermidis, one case Enterococcus faecalis, and one case head-like Staphylococcus). The culture of the fifth patient did not have bacterial growth. One year following treatment, four patients had restored visual acuity and a clear vitreous cavity. Retinal detachment and other complications were not observed. The remaining patient had a visual acuity of index at 30 cm one year following treatment. For patients with endophthalmitis after cataract surgery, a biochemical laboratory examination should be promptly performed and should include a bacterial culture and drug sensitivity test. When necessary, vitrectomy combined with an intravitreal injection of vancomycin should be performed to treat the infection early and to help retain useful vision.

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Acute-Onset Endophthalmitis after Clear Corneal Cataract Surgery (1996–2005)

Cited by 190 publications

References 10 publications

Suspected Bacterial Endophthalmitis following Intravitreal Anti-VEGF Injection: Case Series and Literature Review

Suspected Bacterial Endophthalmitis following Intravitreal Anti-VEGF Injection: Case Series and Literature Review

Endophthalmitis Following Cataract Surgery: Clinical Features, Treatment and Prophylaxis

Clinical features and treatment of endophthalmitis after cataract surgery

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