Acute-on-chronic liver failure in patients with severe acute respiratory syndrome coronavirus 2 infection

Liptak, Peter; Nosáková, Lenka; Rosolanka, Robert; Skladaný, Ľubomír; Bánovčin, Peter

doi:10.4254/wjh.v15.i1.41

Cited by 4 publications

(4 citation statements)

References 75 publications

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“…The SARS-CoV-2 virus primarily targets the lung tissue. However, its impact on other organ systems, such as the gastrointestinal system, circulatory, or central nervous system, has been well described [ 1 , 2 , 3 , 4 , 5 ]. The virus, present in the organism, was able to induce changes in the metabolism of various molecules (e.g., glucose, cholesterol, amino acids, tryptophan, etc.)…”

Section: Introductionmentioning

confidence: 99%

Changes in the Urine Metabolomic Profile in Patients Recovering from Severe COVID-19

et al. 2023

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Metabolomics is a relatively new research area that focuses mostly on the profiling of selected molecules and metabolites within the organism. A SARS-CoV-2 infection itself can lead to major disturbances in the metabolite profile of the infected individuals. The aim of this study was to analyze metabolomic changes in the urine of patients during the acute phase of COVID-19 and approximately one month after infection in the recovery period. We discuss the observed changes in relation to the alterations resulting from changes in the blood plasma metabolome, as described in our previous study. The metabolome analysis was performed using NMR spectroscopy from the urine of patients and controls. The urine samples were collected at three timepoints, namely upon hospital admission, during hospitalization, and after discharge from the hospital. The acute COVID-19 phase induced massive alterations in the metabolic composition of urine was linked with various changes taking place in the organism. Discriminatory analyses showed the feasibility of successful discrimination of COVID-19 patients from healthy controls based on urinary metabolite levels, with the highest significance assigned to citrate, Hippurate, and pyruvate. Our results show that the metabolomic changes persist one month after the acute phase and that the organism is not fully recovered.

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Section: Introductionmentioning

confidence: 99%

Changes in the Urine Metabolomic Profile in Patients Recovering from Severe COVID-19

et al. 2023

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“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID- 19), which has millions of confirmed cases worldwide. SARS-CoV-2 infection can affect the respiratory tract and other organ systems, resulting in various multi-organ complications [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Hematological Patterns from Up to 985 Days of Long COVID: A Cross-Sectional Study

Galúcio

Menezes

Lima

et al. 2023

Viruses

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Long COVID affects many individuals following acute coronavirus disease 2019 (COVID-19), and hematological changes can persist after the acute COVID-19 phase. This study aimed to evaluate these hematological laboratory markers, linking them to clinical findings and long-term outcomes in patients with long COVID. This cross-sectional study selected participants from a ‘long COVID’ clinical care program in the Amazon region. Clinical data and baseline demographics were obtained, and blood samples were collected to quantify erythrogram-, leukogram-, and plateletgram-related markers. Long COVID was reported for up to 985 days. Patients hospitalized in the acute phase had higher mean red/white blood cell, platelet, and plateletcrit levels and red blood cell distribution width. Furthermore, hematimetric parameters were higher in shorter periods of long COVID than in longer periods. Patients with more than six concomitant long COVID symptoms had a higher white blood cell count, a shorter prothrombin time (PT), and increased PT activity. Our results indicate there may be a compensatory mechanism for erythrogram-related markers within 985 days of long COVID. Increased levels of leukogram-related markers and coagulation activity were observed in the worst long COVID groups, indicating an exacerbated response after the acute disturbance, which is uncertain and requires further investigation.

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“…Recent reports have identified that SARS-CoV-2 may associate with long-term, extrapulmonary complications in addition to respiratory tract damage [9][10][11][12]. SARS-CoV-2 infection may impact male fertility by reducing semen quality and increasing levels of oxidative stress [9].…”

Section: Introductionmentioning

confidence: 99%

“…SARS-CoV-2 infection may impact male fertility by reducing semen quality and increasing levels of oxidative stress [9]. Moreover, SARS-CoV-2 can directly affect hepatocytes as a result of systemic inflammation, cytokine release syndrome, and hypoxia that are associated with the virus [10]. Other SARS-CoV-2-related complications include preeclampsia and neurological manifestations [11,12].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Plasma 25(OH)D3 and Vitamin D Binding Protein Levels with COVID-19 Severity and Outcome in Hospitalized Patients

et al. 2023

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Background: The Coronavirus Disease-19 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a worldwide pandemic. The severity of COVID-19 varies greatly across infected individuals. Possible factors may include plasma levels of 25(OH)D and vitamin D binding protein (DBP), as both are involved in the host immune response. Other possible nutrition-related factors include malnutrition and/or obesity which disrupt the optimal host immune response to infections. Current literature shows inconsistent evidence about the association of plasma 25(OH)D3 and DBP on infection severity and clinical outcomes. Objectives: This study aimed to measure plasma 25(OH)D3 and DBP in hospitalized COVID-19 cases and assess their correlation with infection severity, inflammatory markers, and clinical outcome. Methods: 167 patients were included in this analytical cross-sectional study, of which 81 were critical and 86 were non-critical hospitalized COVID-19 patients. Plasma levels of 25(OH)D3, DBP, and the inflammatory cytokines, IL-6, IL-8, IL-10, and TNF-α were assessed using the Enzyme-linked Immunosorbent Assay (ELISA). Information regarding biochemical and anthropometrical indices, hospital length of stay (LoS), and illness outcome was obtained from the medical records. Results: Plasma 25(OH)D3 level was found to be significantly lower in critical compared to non-critical patients (Median = 8.38 (IQR = 2.33) vs. 9.83 (IQR = 3.03) nmol/L, respectively; p < 0.001), and it positively correlated with hospital LoS. However, plasma 25(OH)D3 did not correlate with mortality or any of the inflammatory markers. DBP on the other hand correlated positively with mortality (rs = 0.188, p = 0.015) and hospital LoS (rs = 0.233, p = 0.002). DBP was significantly higher in critical than non-critical patients (Median = 1262.18 (IQR = 463.66) vs. 1153.35 (IQR = 418.46) ng/mL, respectively; p < 0.001). Furthermore, IL-6 and IL-8 were significantly higher in critical than non-critical patients. However, no differences were found in IL-10, TNF-α, IL-10/TNF-α, TNF-α/IL-10, IL-6/IL-10, or CRP between groups. Conclusion: The current study found that critical COVID-19 patients had lower 25(OH)D3 than non-critical patients, yet, levels were found to be suboptimal in both groups. Further, critical patients had higher DBP levels as compared to non-critical patients. This finding may encourage future research to unravel the effects of this understudied protein that appears to have significant associations with inflammation, even though the precise mechanism is unknown.

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Acute-on-chronic liver failure in patients with severe acute respiratory syndrome coronavirus 2 infection

Cited by 4 publications

References 75 publications

Changes in the Urine Metabolomic Profile in Patients Recovering from Severe COVID-19

Changes in the Urine Metabolomic Profile in Patients Recovering from Severe COVID-19

Evaluation of the Hematological Patterns from Up to 985 Days of Long COVID: A Cross-Sectional Study

Correlation of Plasma 25(OH)D3 and Vitamin D Binding Protein Levels with COVID-19 Severity and Outcome in Hospitalized Patients

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