Acute-on-chronic liver failure due to thiamazole in a patient with hyperthyroidism and trilogy of Fallot: case report

Shen, Chuan; Zhao, Caiyan; Liu, Fang; Wang, Yadong; Yu, Jun

doi:10.1186/1471-230x-10-93

Cited by 14 publications

(10 citation statements)

References 16 publications

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“…This is consistent with the above‐mentioned study . Many studies showed that the occurrence of MMI‐DILI was in a dose‐dependent relationship, indicating that MMI‐DILI may be associated with the pharmacokinetics of MMI . We proposed that the higher OATP1B1 activity resulted in the more clearance of MMI, which might decrease the risk of MMI‐DILI.…”

Section: Discussionsupporting

confidence: 90%

“…47 Many studies showed that the occurrence of MMI-DILI was in a dose-dependent relationship, indicating that MMI-DILI may be associated with the pharmacokinetics of MMI. [52][53][54] We proposed that the higher OATP1B1 activity resulted in the more clearance of MMI, which might decrease the risk of MMI-DILI. However, further studies are warranted to determine whether OATP1B1 participates in the transport of MMI and the effects of SLCO1B1 polymorphisms on OATP1B1 activity both in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

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Association between genetic polymorphisms of SLCO1B1 and susceptibility to methimazole‐induced liver injury

Jin

Fan

et al. 2019

Basic Clin Pharma Tox

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Methimazole (MMI) has been used in the therapy of Grave's disease (GD) since 1954, and drug‐induced liver injury (DILI) is one of the most deleterious side effects. Genetic polymorphisms of drug‐metabolizing enzymes and drug transporters have been associated with drug‐induced hepatotoxicity in many cases. The aim of this study was to investigate genetic susceptibility of the drug‐metabolizing enzymes and drug transporters to the MMI‐DILI. A total of 44 GD patients with MMI‐DILI and 118 GD patients without MMI‐DILI development were included in the study. Thirty‐three single nucleotide polymorphisms (SNPs) in twenty candidate genes were genotyped. We found that rs12422149 of SLCO2B1, rs2032582_AT of ABCB1, rs2306283 of SLCO1B1 and rs4148323 of UGT1A1 exhibited a significant association with MMI‐DILI; however, no significant difference existed after Bonferroni correction. Haplotype analysis showed that the frequency of SLCO1B1*1a (388A521T) was significantly higher in MMI‐DILI cases than that in the control group (OR = 2.21, 95% CI = 1.11‐4.39, P = 0.023), while the frequency of SLCO1B1*1b (388G521T) was significantly higher in the control group (OR = 0.52, 95% CI = 0.29‐0.93, P = 0.028). These results suggested that genetic polymorphisms of SLCO1B1 were associated with susceptibility to MMI‐DILI. The genetic polymorphism of SLCO1B1 may be important predisposing factors for MMI‐induced hepatotoxicity.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Association between genetic polymorphisms of SLCO1B1 and susceptibility to methimazole‐induced liver injury

Jin

Fan

et al. 2019

Basic Clin Pharma Tox

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“…In a study comparing the appearance of hepatotoxicity defined as an elevation of transaminases more than threefold, it was found that MMI 30 mg per day dosing caused the earliest appearance of hepatotoxicity compared with 15 mg per day of MMI and 300 mg per day of PTU [23]. The average onset of hepatotoxicity with the higher dose of MMI was found to be about 17 days.…”

Section: And Hepatotoxicitymentioning

confidence: 95%

“…Some studies have suggested monitoring of the liver function tests should be done in the time frame of expected side effects of hepatotoxicity [23].…”

Section: Monitoringmentioning

confidence: 99%

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Propylthiouracil, and methimazole, and carbimazole-related hepatotoxicity

Akmal

Kung²

2014

Expert Opinion on Drug Safety

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PTU is known to cause severe hepatic failure, particularly in children. Its use in children should be avoided. In adults, it is beneficial to use in the first trimester of pregnancy and thyroid storm. In the rest of the adult population, it should be used with caution. Carbimazole and MMI are associated with less severe hepatic injury and should be preferred when choosing thionamides as a treatment option.

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Novel compounds that enhance Agrobacterium-mediated plant transformation by mitigating oxidative stress

et al. 2014

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Agrobacterium tumefaciens caused tissue browning leading to subsequent cell death in plant transformation and novel anti-oxidative compounds enhanced Agrobacterium -mediated plant transformation by mitigating oxidative stress. Browning and death of cells transformed with Agrobacterium tumefaciens is a long-standing and high impact problem in plant transformation and the agricultural biotechnology industry, severely limiting the production of transgenic plants. Using our tomato cv. MicroTom transformation system, we demonstrated that Agrobacterium caused tissue browning (TB) leading to subsequent cell death by our correlation study. Without an antioxidant (lipoic acid, LA) TB was severe and associated with high levels of GUS transient expression and low stable transformation frequency (STF). LA addition shifted the curve in that most TB was intermediate and associated with the highest levels of GUS transient expression and STF. We evaluated 18 novel anti-oxidative compounds for their potential to enhance Agrobacterium-mediated transformation, by screening for TB reduction and monitoring GUS transient expression. Promising compounds were further evaluated for their effect on MicroTom and soybean STF. Among twelve non-antioxidant compounds, seven and five significantly (P < 0.05) reduced TB and increased STF, respectively. Among six antioxidants four of them significantly reduced TB and five of them significantly increased STF. The most efficient compound found to increase STF was melatonin (MEL, an antioxidant). Optimal concentrations and stages to use MEL in transformation were determined, and Southern blot analysis showed that T-DNA integration was not affected by MEL. The ability of diverse compounds with different anti-oxidative mechanisms can reduce Agrobacterium-mediated TB and increase STF, strongly supporting that oxidative stress is an important limiting factor in Agrobacterium-mediated transformation and the limiting factor can be controlled by these compounds at different levels.

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Acute-on-chronic liver failure due to thiamazole in a patient with hyperthyroidism and trilogy of Fallot: case report

Cited by 14 publications

References 16 publications

Association between genetic polymorphisms of SLCO1B1 and susceptibility to methimazole‐induced liver injury

Association between genetic polymorphisms of SLCO1B1 and susceptibility to methimazole‐induced liver injury

Propylthiouracil, and methimazole, and carbimazole-related hepatotoxicity

Novel compounds that enhance Agrobacterium-mediated plant transformation by mitigating oxidative stress

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