Acute-on-Chronic Liver Failure (ACLF) in Coastal Eastern India: “A Single-Center Experience”

Abstract

ACLF patients in our population had high short-term mortality rates with majority of deaths in alcoholics. Alcohol intake and bacterial infections were mainly responsible for AD in our study.

Acute‐on‐chronic liver failure in India: The Indian National Association for Study of the Liver consortium experience

“…Approximately 42% (415) of patients had creatinine > 1.5 mg/dL. The median CTP and MELD scores were 12 (6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and 27 (6-40), respectively.…”

“…There is paucity of data from India; most studies are single-center with small sample size. [4][5][6][7][8][9][10][11][12][13] Therefore, the Indian National Association for Study of the Liver (INASL) formed the INASL Consortium for ACLF Research in the East (ICARE) that included 10 tertiary care centers from all parts of India and planned the present study to assess etiologies, course, and outcomes of patients with ACLF seen across India.…”

Acute-on-chronic liver failure in a multi-ethnic Asian city: A comparison of patients identified by Asia-Pacific Association for the Study of the Liver and European Association for the Study of the Liver definitions

“…The prevalence of HBV is expected given that Singapore lies within the Asia-Pacific region and in most Asian countries, hepatitis B constitutes about 70% of all chronic etiologies of ACLF. Alcoholic liver cirrhosis represents 50%-70% of all underlying etiologies of ACLF in Western countries[ 5 , 11 , 12 ]. The fact that alcoholic liver cirrhosis constitutes such a high proportion of the study population suggests a Western influence on the local community as well.…”

Safety and efficacy of antibiotics among acutely decompensated cirrhosis patients

“…These precipitants include toxins, drug exposure, alcohol consumption, trauma, including surgical, acute kidney injury, hepatic vein, or portal vein thrombosis, hepatocellular carcinoma, and infection. Infection is a leading cause of ACLF . Acute worsening could also be due to worsening of underlying chronic liver diseases such as autoimmune hepatitis, primary sclerosing cholangitis, hepatitis B viral infection, and alcohol liver disease …”

“…Infection is a leading cause of ACLF . Acute worsening could also be due to worsening of underlying chronic liver diseases such as autoimmune hepatitis, primary sclerosing cholangitis, hepatitis B viral infection, and alcohol liver disease …”