Acute nosocomial HCV infection detected by NAT of a regular blood donor

Larke, Bryce; Hu, Yu-Wen; Krajden, Mel; Scalia, Vito; Byrne, Seán; Boychuk, Lesia R; Klein, Judith

doi:10.1046/j.1537-2995.2002.00112.x

Cited by 14 publications

(9 citation statements)

References 20 publications

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“…For example, the donor who had an occupationally acquired infection did not recognize that an exposure had taken place, and the donor with a sexual partner who was engaged in IDU was not aware of this behavior until after his NAT‐positive donation. The single HCV NAT‐positive, anti‐HCV‐seronegative donor reported from Canada was determined to be infected by contamination of a reused IV antibiotic delivery system 22 . Overall, we may have reached the maximum efficiency of the donor history questions, and NAT will continue to be an important measure to interdict recently infected blood donors.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for HCV infection among blood donors confirmed to be positive for the presence of HCV RNA and not reactive for the presence of anti‐HCV

Orton¹,

Stramer²,

Dodd³

et al. 2004

Transfusion

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Section: Discussionmentioning

confidence: 99%

Risk factors for HCV infection among blood donors confirmed to be positive for the presence of HCV RNA and not reactive for the presence of anti‐HCV

Orton¹,

Stramer²,

Dodd³

et al. 2004

Transfusion

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“…Although the majority of HCV‐positive donors had at least one of the six risk factors in the model, there were some donors who did not admit to any of these. These donors could have had exposure to rare or less specific risk factors such as nosocomial infections, 22 the effect of which some studies have attempted to tease out 19,23 . Such risk factors, however, are not necessarily causal; may vary in different jurisdictions depending on, for example, infectious disease control policies; and are not sufficiently specific to be applied as donor exclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

Declining hepatitis C rates in first‐time blood donors: insight from surveillance and case‐control risk factor studies

O’Brien

Wang

et al. 2008

Transfusion

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Most HCV-positive donors were born between 1945 and 1964, and the decline in HCV rates is associated primarily with this birth cohort. The key risk factors predicting HCV positivity did not change over the 13 years of the study. With approximately two-thirds of HCV-positive Canadians in the general population having been tested for HCV, potential donors may be aware of their HCV status and be likely to self-defer. This, and an increasing proportion of first-time donors born after 1964, may contribute to declining HCV rates in first-time donors.

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“…HCV positive sample 6048 (genotype 1b) and sample 6005 (genotype 2a) were used for the amplification of the full‐length NS5A gene. In each case, virus positive plasma samples were collected before IFN therapy and the viral load was assessed prior to as well as following IFN therapy using the COBAS Amplicor HCV MonitorTest, v2.0 (Roche Diagnostics, Indianapolis, IN) [Larke et al, 2002].…”

Section: Methodsmentioning

confidence: 99%

Hepatitis C virus: The role of molecular mimicry in response to interferon treatment

Uzicanin

Alsousi

et al. 2012

Journal of Medical Virology

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Chronic hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease worldwide. In order for HCV to persist, the virus must escape immune recognition or inhibit the host immune response. The NS5A protein contains the interferon sensitivity-determining region (ISDR) and is able to repress dsRNA-dependent protein kinase (PKR) thus influencing the response to interferon (IFN) therapy. Patients who respond to IFN therapy have stronger antibody reactivity against the NS5A compared to IFN non-responders. Therefore, given the possible role for the ISDR in IFN resistance and differential antibody reactivity, it is possible that variation in ISDR may be involved in viral immune escape and development of persistent HCV infection employing aspects of host mimicry. In this study, pre-treatment samples obtained from HCV infected patients were used to investigate the effect of different NS5A ISDR variants on the IFN antiviral response and their involvement in immune evasion. The NS5A was identified as a homologue of the variable region of immunoglobulins (Ig). The IFN resistant genotypes had higher levels of similarity to Ig compared to IFN sensitive genotypes. Expression of NS5A-6003 (HCV genotype 1b) and NS5A-6074 (HCV genotype 2a) was able to rescue vesicular stomatitis virus (VSV) from IFN inhibition and restore luciferase activity. A correlation between Ig-like NS5A structure and also antibody response with the outcome of IFN treatment was observed.

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Acute nosocomial HCV infection detected by NAT of a regular blood donor

Cited by 14 publications

References 20 publications

Risk factors for HCV infection among blood donors confirmed to be positive for the presence of HCV RNA and not reactive for the presence of anti‐HCV

Risk factors for HCV infection among blood donors confirmed to be positive for the presence of HCV RNA and not reactive for the presence of anti‐HCV

Declining hepatitis C rates in first‐time blood donors: insight from surveillance and case‐control risk factor studies

Hepatitis C virus: The role of molecular mimicry in response to interferon treatment

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