Acute Normovolemic Hemodilution Effects on Perioperative Coagulation in Elderly Patients Undergoing Hepatic Carcinectomy

Guo, Juan; Jin, Xiaohui; Yu, Jun; Xu, Feng; Zhang, Yi-Wei; Shen, Huan; Shao, Yi

doi:10.7314/apjcp.2013.14.8.4529

Cited by 9 publications

(19 citation statements)

References 12 publications

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“…It has been widely used in postpartum hemorrhage, and cancer and orthopedic surgeries, such as joint replacement and spine surgery. These surgeries often have large traumatic areas and a large amount of bleeding, and patients often need blood transfusions (24 -26). ANH advantages include the following.…”

Section: Acute Normovolemic Hemodilution Abtmentioning

confidence: 99%

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A review of the application of autologous blood transfusion

Zhou¹

2016

Braz J Med Biol Res

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Autologous blood transfusion (ABT) has been gradually attracting more attention due to the increasingly prominent problem of blood transfusion safety and blood shortage in recent years. With the rapid development of blood conservation techniques, blood component separation technology, blood transfusion medicine and a constant increase in clinical needs, ABT technology has been expanded and innovated to a large degree. In this study, the development of preoperative autologous blood donation (PABD), acute normovolemic hemodilution (ANH), intraoperative and postoperative autotransfusion, and other new technologies and theories are reviewed and existing questions are analyzed. Challenges and applications are also discussed in order to provide reference for peers.

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Section: Acute Normovolemic Hemodilution Abtmentioning

confidence: 99%

“…The application of ANH ABT in malignant tumor surgery can reduce the amount of allogeneic blood transfusion, save money and prevent blood borne diseases. At the same time, it can induce the production of a variety of immune factors (25) without affecting liver and blood coagulation functions (26). …”

Section: Acute Normovolemic Hemodilution Abtmentioning

confidence: 99%

A review of the application of autologous blood transfusion

Zhou¹

2016

Braz J Med Biol Res

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“…Eight studies were judged to be of low risk of bias with five studies at low risk of randomization bias without explicit details of allocation concealment or blinding of outcome assessment. Randomization details were unclear in four studies …”

Section: Resultsmentioning

confidence: 99%

“…There were a total of 238 patients undergoing liver resection that were randomized across three trials to haemodilution (n = 117) or control (n = 121). The number of participants in each trial was 78 (Matot et al 20 ), 130 (Jarnagin et al 1 ) and 30 (Guo et al 32 ). In all studies, the volume of blood to be removed was calculated preoperatively.…”

Section: Haematological Controlmentioning

confidence: 99%

Anaesthetic and pharmacological techniques to decrease blood loss in liver surgery: a systematic review

Pathak

Hakeem

Pike

et al. 2015

ANZ Journal of Surgery

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Background: There is increasing evidence that perioperative blood loss and blood transfusions are associated with poorer short-and long-term outcomes in patients undergoing hepatectomy. The aim of this study was to systematically review the literature for non-surgical measures to decrease intraoperative blood loss during liver surgery. Methods: The literature search was performed using PubMed, Embase, Cochrane Library, CINAHL and Google Scholar databases. The primary outcome measures were perioperative blood loss and transfusion requirements. A secondary outcome measure was development of ischaemia-reperfusion injury. Results: Seventeen studies met the inclusion criteria and included 1573 patients. All were randomized controlled studies. In eight studies (n = 894), pharmacological methods, and in another nine studies (n = 679), anaesthetic methods to decrease blood loss were investigated. Anti-fibrinolytic drugs, acute normovolaemic haemodilution, autologous blood donation and use of inhalational anaesthetic agent may affect blood loss and post-operative hepatic function. Conclusions: There is potential for use of non-surgical techniques to decrease perioperative bleeding. However, on the basis of this review alone, due to heterogeneity of randomized trials conducted, no particular strategy can be recommended. Future studies should be conducted looking at pathways to decrease bleeding in liver surgery.

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“…Acute normovolemic hemodilution (ANH) is usually carried out to preserve red blood cell, leading reduce the amount of intra-and postoperative allogenic blood transfusion in several clinical settings [1][2][3][4][5]. Moreover, in cardiovascular surgical setting, in addition to the reduction of the risk of postoperative allogeneic blood transfusion, ANH also can reduce the amount of post-operative blood loss [6].…”

Section: Introductionmentioning

confidence: 99%

Clotting functional stability of withdrawing blood in storage for acute normovolemic hemodilution: a pilot study

et al. 2020

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Purpose This study was conducted to time-course changes of clotting function of withdrawing blood for acute normovolemic hemodilution (ANH). Methods Twelve enrolled patients who underwent ANH from August, 2018 to January, 2019. Blood was withdrawn into blood collection pack and shaken at 60–80 rpm for 24 h in room temperature. Clot formation was evaluated using rotational thromboelastometry (ROTEM™) just after blood withdrawal (control) and 4, 8, 12 and 24 h after blood withdrawal. We compared with the control value and each value of extrinsically-activated test with tissue factor (EXTEM), intrinsically-activated test using ellagic acid (INTEM) and fibrin-based extrinsically activated test with tissue factor (FIBTEM). Results Maximum clot firmness (MCF) of FIBTEM did not change significantly. MCF of EXTEM was significantly decreased time-dependent manner but all MCF of EXTEM were within a normal range. Maximum percent change in MCF of EXTEM was 12.4% [95% confidence interval (CI): 9.0–15.8%]. The difference in the maximum clot elasticity (MCE) between EXTEM and FIBTEM (MCEEXTEM−MCEFIBTEM) was significantly decrease from 8 h after blood withdrawal. Maximum percent change in MCEEXTEM−MCEFIBTEM was 30.2% (95% CI:17.6–42.9%) at 24 h after blood withdrawal. Conclusion Even though the MCE significantly decreased in a time-dependent manner, MCF of FIBTEM and EXTEM was normal up to 24 h storage. The blood of ANH can use for the purpose of hemostasis at least 8 h stored at room temperature after blood withdrawal. Future studies are needed to elucidate the clinical impact on the patient after delayed transfusion of ANH blood with regard to patient’s hemostasis.

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Acute Normovolemic Hemodilution Effects on Perioperative Coagulation in Elderly Patients Undergoing Hepatic Carcinectomy

Cited by 9 publications

References 12 publications

A review of the application of autologous blood transfusion

A review of the application of autologous blood transfusion

Anaesthetic and pharmacological techniques to decrease blood loss in liver surgery: a systematic review

Clotting functional stability of withdrawing blood in storage for acute normovolemic hemodilution: a pilot study

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