Acute, nontraumatic subdural hemorrhage as a presentation of meningioma: A report of two cases and literature review

Acute spontaneous subdural hematoma: A literature review

“…Reforçando a existência dessa apresentação típica mesmo em pacientes diferentes, Mezzacappa et al (2022) acompanharam dois casos de meningiomas, uma neoplasia primária do sistema nervoso central. O quadro clínico varia com a localização do tumor, mas os sintomas mais comuns incluem cefaleia e déficits neurológicos focais.…”

Letter: Nationwide Readmission Rates and Hospital Charges for Patients With Surgical Evacuation of Nontraumatic Subdural Hematomas: Part 1—Craniotomy

“…Similarly, meningiomas have been described as a cause of aSDHs; so far, a little more than 40 cases have been described according to Mezzacappa et al 10 ; however, the pathophysiology of how meningiomas produce aSDHs is uncertain. It is estimated that meningiomas can produce several growth factors such as vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1 (HIF-1), and epidermal growth factor (EGF) which produce increased angiogenesis and generation of vessels with an abnormal nature that make them susceptible to rupture and subsequent bleeding.…”

“…Among the neoplasms with the capacity to generate aSDHs are brain metastases of grade IV prostatic adenocarcinoma, which rarely metastasize to the central nervous system since the affinity of this type of tumor is for the bone; however, it is believed that because of the proximity of the bone table with the dura mater, these tumors can migrate and generate this type of lesions. 9 Similarly, meningiomas have been described as a cause of aSDHs; so far, a little more than 40 cases have been described according to Mezzacappa et al 10 ; however, the pathophysiology of how meningiomas produce aSDHs is uncertain. It is estimated that meningiomas can produce several growth factors such as vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1 (HIF-1), and epidermal growth factor (EGF) which produce increased angiogenesis and generation of vessels with an abnormal nature that make them susceptible to rupture and subsequent bleeding.…”

“…It is estimated that meningiomas can produce several growth factors such as vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1 (HIF-1), and epidermal growth factor (EGF) which produce increased angiogenesis and generation of vessels with an abnormal nature that make them susceptible to rupture and subsequent bleeding. 10 On the other hand, it has been described that aneurysm rupture can cause aSDHs; however, its prevalence is unknown. Aneurysm rupture is generally associated with the development of subarachnoid hemorrhage, but given the proximity to the subdural space, bleeding can occur in this space.…”

“…It is estimated that meningiomas can produce several growth factors such as vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1 (HIF-1), and epidermal growth factor (EGF) which produce increased angiogenesis and generation of vessels with an abnormal nature that make them susceptible to rupture and subsequent bleeding. 10…”