Acute nonlymphocytic leukemia with a translocation (1;3)(p36;q21) in an XYY man

Atichartakarn, Vichai; Punyammalee, Boonnum; Wongsasant, Budsaba; Jootar, Saengsuree

doi:10.1016/0165-4608(86)90202-5

Cited by 23 publications

(2 citation statements)

References 17 publications

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“…1 A few haematological malignancies have been reported in patients with XYY syndrome, occurring in acute myeloid leukaemia without maturation, acute myeloid leukaemia with maturation, chronic myeloid leukaemia, and acute lymphoblastic leukaemia. [13][14][15][16][17] To the best of our knowledge, this is the first case reporting a patient with 47,XYY syndrome with APL. The male patient described in this current case report had a tall stature, normal intelligence and testosterone levels, and did not exhibit aggressive behaviour.…”

Section: Discussionmentioning

confidence: 99%

Acute promyelocytic leukaemia with a PML-RARA insertional translocation and a chromosome 21 abnormality in XYY syndrome: Case report

Wang

et al. 2014

J Int Med Res

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The concomitant presence of the XYY syndrome with haematological malignancies is rare. This report presents a case of acute promyelocytic leukaemia (APL) with the promyelocytic leukaemiaretinoic acid receptor alpha (PML-RARA) gene insertional translocation and a chromosome 21 abnormality in a 29-year-old XYY male patient. Karyotype analysis revealed an abnormal karyotype of 47,XYY [14]/46,XYY,-21 [16]. Fluorescence in situ hybridization and reverse transcriptionpolymerase chain reaction analysis showed the existence of a PML-RARA fusion gene. The patient was treated by all-trans retinoic acid (ATRA) and chemotherapy. Laboratory results revealed that the coagulopathy improved and the patient achieved complete remission, based on bone-marrow morphology. The patient then received sequential monthly therapy using arsenic trioxide, followed by ATRA, followed by chemotherapy; he has survived disease-free for 36 months. Our findings suggest that the additional chromosomal abnormalities involving the sex chromosomes and chromosome 21 did not affect the prognosis of APL, and that the sequential treatment strategy had a good clinical effect without being associated with severe side-effects.

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Section: Discussionmentioning

confidence: 99%

Acute promyelocytic leukaemia with a PML-RARA insertional translocation and a chromosome 21 abnormality in XYY syndrome: Case report

Wang

et al. 2014

J Int Med Res

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“…I1 est remarquable de constater que depuis une dizaine d'ann~es, la pathologie h~matologique a pris le relais. Nombreuses sont les ~tudes r~alis~es qui semblent mettre en ~vidence une predisposition des hommes XYY aux leuc~mies [1][2][3]32].…”

Section: Pathologie Hematologiqueunclassified

Les Hommes XYY

Amblard

Jalbert

1994

Androl.

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2bme dysgonosomie, elle repr~sente 1/851 /l 1/1 000 naissances masculines. Mis /~ part leur grande taille, ces hommes ne se distinguent en rien de la population g~n~rale. Les quelques dif-ficult~s d'apprentissage rencontr~es sont facilement jugul~es par un soutien familial et ~ducatif, ce d'autant plus facilement qu'elles ne sont pas dues/~ un retard mental. Une prise en charge adequate leur permettra de devenir des adultes avec une bonne adaptation familiale, conjugale et sociale. Le plus grand nombre est fertile et leur descendance est normale par ~limination au cours de la spermatoge. n~se de 1' Y surnum~raire.

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