Acute nonlymphocytic leukemia in systemic mastocytosis with biclonal gammopathy

Lindner, Paul S.; Pardanani, Bhagwati; Angadi, Channabapassa; Frieri, Marianne

doi:10.1016/s0091-6749(05)80024-7

Cited by 17 publications

(10 citation statements)

References 6 publications

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“…These hybrid basophilic/eosinophilic cells have been detected previously in the bone marrow and cord blood as well as peripheral blood of patients with myeloid leukemia [44-45]. Both adults and children with mastocytosis can develop leukemias [46-49]. A recent study demonstrated that hybrid basophilic/eosinophilic cells are derived from CD34 + CD133 low/- cord blood cell progenitors [33].…”

Section: Do Human Basophils and Mast Cells Share Common Progenitors?mentioning

confidence: 82%

Mechanisms Controlling Mast Cell and Basophil Lineage Decisions

Huang

2014

Curr Allergy Asthma Rep

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Basophils and mast cells have long been known to play critical roles in allergic disease and host defense against parasitic infections. Recent recognition of these effector cells in immune regulations, host defense against bacterial and virus, and autoimmune diseases entices increased interest in studying these cells. However, origin and molecular regulation of basophil and mast cell differentiation remain incompletely understood. In this review, we focus on recent advances of the understanding the origin and molecular regulation of mouse basophil and mast cell development. We also summarize progress in the understanding of the origin and molecular regulation of human basophil and mast cell development. A more complete understanding of molecular regulation of basophils and mast cells will lead to the development of interventions that are more effective in achieving long-term success.

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Section: Do Human Basophils and Mast Cells Share Common Progenitors?mentioning

confidence: 82%

Mechanisms Controlling Mast Cell and Basophil Lineage Decisions

Huang

2014

Curr Allergy Asthma Rep

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“…17 He was diagnosed with acute nonlymphocytic leukemia. 18 Pediatric mastocytosis is often mistaken for more common rashes such as in one study with a 9-month-old boy who presented with a rash that was originally mistaken for a milk allergy and then for atopic dermatitis, 19 or a 10-month-old boy with recurrent urticarial episodes. 20 Krishnan reported a solitary mastocytoma in 14-year-old boy with urticaria and angioedema.…”

Section: Acute Myeloid Leukemia and Selected Clinical Casesmentioning

confidence: 99%

Pediatric Mastocytosis: A Review of the Literature

Frieri

Quershi

2013

Pediatric Allergy, Immunology, and Pulmonology

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Mastocytosis has a bimodal distribution often presenting in children from birth to 2 years of age and in those over the age of 15. Pediatric mastocytosis is due to the effects of mast-cell degranulation enzymes such as histamine and tryptase causing the presentation of pruritis, flushing, vesicles, abdominal and bone pain, or headache. Three different forms of mastocytosis can occur: urticaria pigmentosa, diffuse cutaneous, and solitary mastocytoma. Systemic symptoms are typically a result of mast-cell mediator release but do not prove systemic mast-cell hyperplasia. In this review, we present several research studies related to pediatric mast-cell disorders, and discuss several cases of pediatric mastocytosis, acute myeloid leukemia, pathophysiology, genetic studies, and treatment. Introduction and Research Studies

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“…SM (systemic mastocytosis) may be accompanied or complicated by a second hematologic disease process [11,[17][18][19][20][21][22][23]. Mostly, clonal myeloid disorders occur [11,[17][18][19][20][21]. However, in a very few cases of SM, a co-existing lymphoid disorder such as lymphocytic leukemia or lymphoma has been described [17,[21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have shown that SM can be associated with hematologic abnormalities or even with another hematologic disease process [11,[17][18][19][20][21][22][23]. In most cases, clonal myeloid disorders (neoplasias) such as myeloproliferative syndromes, myelodysplastic syndromes, or acute myeloid leukemias (AML) have been described.…”

Section: Introductionmentioning

confidence: 99%

A case of bone marrow mastocytosis associated with multiple myeloma

Hagen

Schwarzmeier

Walchshofer

et al. 1998

Annals of Hematology

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Mastocytosis is a term used for a spectrum of disorders characterized by abnormal growth and accumulation of mast cells. The cutaneous variants of the disease have to be distinguished from systemic mastocytosis (SM), in which at least one extracutaneous organ is involved. In contrast to cutaneous mastocytosis, SM is often associated with another hematologic neoplasm. In most cases clonal myeloid malignancies such as a myeloproliferative or myelodysplastic syndrome occur. In a few cases of SM, however, clonal lymphoid disorders have been described. We here report on a case of SM associated with multiple myeloma. At first presentation, the 48-year old female patient showed monoclonal IgGlambda gammopathy and bone marrow (BM) mastocytosis, but no BM plasma cell infiltrates. Eight years later, the patient presented with BM mastocytosis and overt multiple myeloma. The co-existence of myeloma and mastocytosis was demonstrable by staining serial BM sections with antibodies against mast cell tryptase, CD68R, and the plasma cell marker VS38c. Interphase FISH analysis of BM sections revealed a numeric gain of chromosome 5 and chromosome 7 in the plasma cells but not in the mast cell infiltrates, thereby confirming the presence of two different neoplastic cell populations. To our knowledge, this is the first report describing the co-existence of multiple myeloma and mastocytosis.

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Acute nonlymphocytic leukemia in systemic mastocytosis with biclonal gammopathy

Cited by 17 publications

References 6 publications

Mechanisms Controlling Mast Cell and Basophil Lineage Decisions

Mechanisms Controlling Mast Cell and Basophil Lineage Decisions

Pediatric Mastocytosis: A Review of the Literature

A case of bone marrow mastocytosis associated with multiple myeloma

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