Acute noncardiogenic pulmonary edema after neostigmine administration during the recovery period of general anesthesia

Zhang, Wenjing; Cong, Ning; Zhao, Guoqing; Su, Zhenbo

doi:10.1097/md.0000000000010525

Cited by 6 publications

(12 citation statements)

References 13 publications

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“…Neostigmine intoxication can be accidental, but it can be used as a poison for homicidal purposes. 34 To further demonstrate future applicability of the micromotors in this field, we evaluate the feasibility of the method in commonly consumed beverages. Samples without previous pretreatment were spiked with different concentrations of neostigmine, and recovery studies were performed.…”

Section: Resultsmentioning

confidence: 99%

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Prussian Blue/Chitosan Micromotors with Intrinsic Enzyme-like Activity for (bio)-Sensing Assays

et al. 2022

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Prussian Blue (PB)/chitosan enzyme mimetic tubular micromotors are used here for on-the-fly (bio)-sensing assays. The micromotors are easily prepared by direct deposition of chitosan into the pores of a membrane template and in situ PB synthesis during hydrogel deposition. Under judicious pH control, PB micromotors display enzyme mimetic capabilities with three key functions on board : the autonomous oxygen bubble propulsion (with PB acting as a catalase mimic for hydrogen peroxide decomposition), 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation (with PB acting as a peroxidase mimic for analyte detection), and as a magnetic material (to simplify the (bio)-sensing steps). In connection with chitosan capabilities, these unique enzyme mimetic micromotors are further functionalized with acetylthiocholinesterase enzyme (ATChE) to be explored in fast inhibition assays (20 min) for the colorimetric determination of the nerve agent neostigmine, with excellent analytical performance in terms of quantification limit (0.30 μM) and concentration linear range (up to 500 μM), without compromising efficient micromotor propulsion. The new concept illustrated holds considerable potential for a myriad of (bio)-sensing applications, including forensics, where this conceptual approach remains to be explored. Micromotor-based tests to be used in crime scenes are also envisioned due to the reliable neostigmine determination in unpretreated samples.

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Section: Resultsmentioning

confidence: 99%

“…Neostigmine intoxication can be accidental, but it can be used as a poison for homicidal purposes . To further demonstrate future applicability of the micromotors in this field, we evaluate the feasibility of the method in commonly consumed beverages.…”

Section: Resultsmentioning

confidence: 99%

Prussian Blue/Chitosan Micromotors with Intrinsic Enzyme-like Activity for (bio)-Sensing Assays

et al. 2022

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“…However, pulmonary edema may occur before extubation in some rare cases. Neostigmine might induce noncardiac pulmonary edema by impairing upper airway function by dilating muscles and causing the upper airway to narrow [1,2]. In this case, pulmonary edema occurred perioperatively, as such, neostigmine hypersensitivity was suspected.…”

Section: Introductionmentioning

confidence: 90%

“…The use of neostigmine is known to be safe and effective. However, several cases of acute pulmonary edema due to the use of neostigmine have been reported [1,2]. Neostigmine-induced pulmonary edema was diagnosed based on the symptoms that occurred soon after the administration of neostigmine, while other causes were ruled out.…”

Section: Case Reportmentioning

confidence: 99%

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Acute Noncardiogenic Pulmonary Edema Following Neostigmine Administration in the Endotracheal Intubation State After Tonsillectomy

et al. 2021

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Acute pulmonary edema during the perioperative period can have various causes. A 20-year-old woman was admitted for tonsillectomy and adenoidectomy. She had nasal congestion for 2 months, chronic sinusitis with polyps, and diffuse lymphoid hyperplasia. A biopsy and peripheral blood smear were performed to rule out a lymphoma before surgery. We injected neostigmine 1.5 mg and glycopyrrolate 0.4 mg at the end of the surgery. Two minutes later, the secretion and peak airway pressure increased as well as the CO2 levels. The patient remained sedated and suctioning continued for approximately 20 min before extubation. The secretions reduced and there was an improvement in clinical symptoms as the pinkish foamy pattern became whitish. Presumed treatment of neostigmine hypersensitivity or surgery can be used to resolve perioperative chronic partial airway obstruction.

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Neostigmine

2018

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Acute noncardiogenic pulmonary edema after neostigmine administration during the recovery period of general anesthesia

Cited by 6 publications

References 13 publications

Prussian Blue/Chitosan Micromotors with Intrinsic Enzyme-like Activity for (bio)-Sensing Assays

Prussian Blue/Chitosan Micromotors with Intrinsic Enzyme-like Activity for (bio)-Sensing Assays

Acute Noncardiogenic Pulmonary Edema Following Neostigmine Administration in the Endotracheal Intubation State After Tonsillectomy

Neostigmine

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