Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study

Dubol, Manon; Jonasson, My; Immenschuh, Jana; Takahashi, Kei; Niwa, Takashi; Hosoya, Takamitsu; Roslin, Sara; Wikström, Johan; Antoni, Gunnar; Watanabe, Yasuyoshi; Lubberink, Mark; Biegon, Anat; Sundström‐Poromaa, Inger; Comasco, Erika

doi:10.1016/j.comppsych.2023.152381

Cited by 3 publications

(2 citation statements)

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“…Furthermore, very low percentages of Cyp19a1 + cells in the CPu as well as the Acb were observed in the current study, which received little attention in previous research on aromatase [ 11 ] but might be of relevance to addiction, as a blocking effect of nicotine on aromatase has been demonstrated [ 37 , 38 ]. Interestingly, rather sparsely and evenly distributed, Cyp19a1 + cells with high expression were seen throughout both regions.…”

Section: Discussioncontrasting

confidence: 54%

“…Thus, more in-depth, hypothesis-free, characterization of cells expressing Cyp19a1 through single-cell sequencing is encouraged, as well as the investigation of other regions, such as the cerebral cortex, the brainstem, the cerebellum, and the thalamus, for which there is evidence of Cyp19a1 expression [ 10 , 11 ]. Such investigations may be relevant to clinical phenotypes as recently pointed by a study on aromatase and nicotine in the human thalamus [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain

Immenschuh,

Thalhammer,

Sundström-Poromaa

et al. 2023

Biol Sex Differ

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Background Aromatase catalyzes the synthesis of estrogens from androgens. Knowledge on its regional expression in the brain is of relevance to the behavioral implications of these hormones that might be linked to sex differences in mental health. The present study investigated the distribution of cells expressing the aromatase coding gene (Cyp19a1) in limbic regions of young adult rats of both sexes, and characterized the cell types expressing this gene. Methods Cyp19a1 mRNA was mapped using fluorescent in situ hybridization (FISH). Co-expression with specific cell markers was assessed with double FISH; glutamatergic, gamma-aminobutyric acid (GABA)-ergic, glial, monoaminergic, as well as interneuron markers were tested. Automated quantification of the cells expressing the different genes was performed using CellProfiler. Sex differences in the number of cells expressing Cyp19a1 was tested non-parametrically, with the effect size indicated by the rank-biserial correlation. FDR correction for multiple testing was applied. Results In the male brain, the highest percentage of Cyp19a1+ cells was found in the medial amygdaloid nucleus and the bed nucleus of stria terminalis, followed by the medial preoptic area, the CA2/3 fields of the hippocampus, the cortical amygdaloid nucleus and the amygdalo-hippocampal area. A lower percentage was detected in the caudate putamen, the nucleus accumbens, and the ventromedial hypothalamus. In females, the distribution of Cyp19a1+ cells was similar but at a lower percentage. In most regions, the majority of Cyp19a1+ cells were GABAergic, except for in the cortical-like regions of the amygdala where most were glutamatergic. A smaller fraction of cells co-expressed Slc1a3, suggesting expression of Cyp19a1 in astrocytes; monoaminergic markers were not co-expressed. Moreover, sex differences were detected regarding the identity of Cyp19a1+ cells. Conclusions Females show overall a lower number of cells expressing Cyp19a1 in the limbic brain. In both sexes, aromatase is expressed in a region-specific manner in GABAergic and glutamatergic neurons. These findings call for investigations of the relevance of sex-specific and region-dependent expression of Cyp19a1 in the limbic brain to sex differences in behavior and mental health.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain

Immenschuh,

Thalhammer,

Sundström-Poromaa

et al. 2023

Biol Sex Differ

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Nicotine as a female reproductive toxicant—A review

Bhardwaj,

Siwach,

Sachdeva

2024

J of Applied Toxicology

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The preceding decades have seen an extensive emergence of the harmful effects of tobacco smoke on systemic health. Among the various compounds of tobacco, nicotine is one of the principal, potentially hazardous, and toxic components which is an oxidant agent that can affect both men's and women's fertility. Nicotine exerts its effect by modulating the expression of transmembrane ligand‐gated ion channels called nicotinic acetylcholine receptors. The activities of female reproduction might be disrupted by exposure to nicotine at various sites, such as the ovary or reproductive tract. It's been demonstrated that nicotine might cause oxidative stress, apoptosis, hormonal imbalance, abnormalities in chromosomal segregation, impact oocyte development, and disruption in ovarian morphology and functions. This review paper summarizes the findings and provides an updated overview of the evidence on the harmful effects of nicotine use on women's reproductive health and the resulting detrimental impacts on the body. Additionally, it provides the detailed possible mechanisms involved in impairing reproductive processes like folliculogenesis, oocyte maturation, steroidogenesis, and pregnancy in different animal species.

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The influence of ovarian hormones on the putative mechanisms that promote female nicotine use

Giner,

Ortegon,

Bagdas

et al. 2024

Current Opinion in Neurobiology

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Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study

Cited by 3 publications

References 62 publications

Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain

Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain

Nicotine as a female reproductive toxicant—A review

The influence of ovarian hormones on the putative mechanisms that promote female nicotine use

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