Acute nickel toxicity in electroplating workers who accidently ingested a solution of nickel sulfate and nickel chloride

Sunderman, F. William; Dingle, Brian; Hopfer, Sidney M.; Swift, Thomas R.

doi:10.1002/ajim.4700140303

Cited by 140 publications

(86 citation statements)

References 11 publications

(2 reference statements)

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“…4, bar 2). The biological half-life of nickel ions is so short that, in men, 50% of the nickel ions in the body are eliminated within 2-3 days (21). Hence, it is likely that after a treatment-free interval of 20 wk, the concentration of nickel ions in the orally tolerized donors was too low to induce new tolerogenic APCs.…”

Section: The Tolerogenic Capacity Of Apcs From Orally Tolerized Mice mentioning

confidence: 99%

Infectious Nickel Tolerance: A Reciprocal Interplay of Tolerogenic APCs and T Suppressor Cells That Is Driven by Immunization

Roelofs-Haarhuis

Wu²,

Nowak³

et al. 2003

The Journal of Immunology

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Previously, we reported that tolerance to nickel, induced by oral administration of Ni2+ ions, can be adoptively transferred to naive mice with only 102 splenic T cells. Here we show that 102 T cell-depleted spleen cells (i.e., APCs) from orally tolerized donors can also transfer nickel tolerance. This cannot be explained by simple passive transfer of the tolerogen. The APCs from orally tolerized donors displayed a reduced allostimulatory capacity, a tolerogenic phenotype, and an increased expression of CD38 on B cells. In fact, it was B cells among the APCs that carried the thrust of tolerogenicity. Through serial adoptive transfers with Ly5.1+ donors and two successive sets of Ly5.2+ recipients, we demonstrated that nickel tolerance was infectiously spread from donor to host cells. After the transfer of either T cells or APCs from orally tolerized donors, the spread of tolerance to the opposite cell type of the recipients (i.e., APCs and T cells, respectively) required recipient immunization with NiCl2/H2O2. For the spread of tolerance from a given donor cell type, T cell or APC, to the homologous host cell type, the respective opposite cell type in the host was required as intermediate. We conclude that T suppressor cells and tolerogenic APCs induced by oral administration of nickel are part of a positive feedback loop that can enhance and maintain tolerance when activated by Ag associated with a danger signal. Under these conditions, APCs and T suppressor effector cells infectiously spread the tolerance to naive T cells and APCs, respectively.

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Section: The Tolerogenic Capacity Of Apcs From Orally Tolerized Mice mentioning

confidence: 99%

Infectious Nickel Tolerance: A Reciprocal Interplay of Tolerogenic APCs and T Suppressor Cells That Is Driven by Immunization

Roelofs-Haarhuis

Wu²,

Nowak³

et al. 2003

The Journal of Immunology

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“…Besides this, the inhalation of vapors of nickel carbonyl certain occupations (welding, fitting, etc.) also causes elevated Ni levels in biological samples [30,31]. This is the first study with comprehensive data on toxic and essential elements in the scalp hair samples of hypertensive and referent subjects of two countries (Pakistan and Ireland).…”

Section: Discussionmentioning

confidence: 99%

Comparative Metal Distribution in Scalp Hair of Pakistani and Irish Referents and Hypertensive Patients

Afridi

Brabazon

Kazi

et al. 2011

Biol Trace Elem Res

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The abnormal metabolism of metal ions plays an important role in health and disease conditions, and studies about them have been attracting significant interest. The aim of our study was to assess the heavy metals (cadmium (Cd), nickel (Ni), lead (Pb), and zinc (Zn)) in scalp hair samples of 50 Irish and 78 Pakistani hypertensive patients of an urban population together with 50 fish and 96 Pakistani non-hypertensive male subjects in the age group of 30-50 years. The concentrations of trace and toxic elements were measured by inductively coupled plasma-atomic emission spectrophotometer and atomic absorption spectrophotometer before microwave-assisted acid digestion. The validity and accuracy of the methodology were checked using certified reference materials, and by the conventional wet acid digestion method on the same certified reference materials and on real samples. The recovery of all the studied elements was found to be in the range of 97.5-99.7% in certified reference material. The results of this study showed that the mean values of cadmium, nickel, and lead were significantly higher in scalp hair samples of both Pakistani and Irish hypertensive patients than in referents (p<0.001), whereas, the concentration of zinc was lower in the scalp hair samples of hypertensive patients of both genders. The deficiency of zinc and the high exposure of trace and toxic metals may be the risk factors associated with hypertension.

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“…However, large doses taken orally may cause nausea, vomiting, abdominal pain, and diarrhea (Sunderman et al, 1988). Workers who accidentally drank water contaminated with 1.63 g Ni/L developed lassitude, headache, giddiness, cough and shortness of breath (Sunderman et al, 1988).…”

Section: Mammalian and Human Health Effectsmentioning

confidence: 99%

Bioremediation of petroleum hydrocarbo-contaminated soils, comprehensive report, December 1999

Hazen¹

2000

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have been cooperating in the development and implementation of innovative environmental remediation technologies since 1995. A major focus of this program has been the demonstration of bioremediation techniques to cleanup the soil and sediment associated with a waste lagoon at the Czechowice Oil Refinery (CZOR) in southern Poland. After an expedited site characterization (ESC), treatability study, and risk assessment study, a remediation system was designed that took advantage of local materials to minimize cost and maximize treatment efficiency. U.S. experts worked in tandem with counterparts from the IETU and CZOR throughout this project to characterize, assess and subsequently, design, implement and monitor a bioremediation system. The CZOR, our industrial partner for this project, was chosen because of their foresight and commitment to the use of new approaches for environmental restoration. This program sets a precedent for Poland in which a portion of the funds necessary to complete the project were provided by the company responsible for the problem. The CZOR was named by PIOS (State Environmental Protection Inspectorate of Poland) as one of the top 80 biggest polluters in Poland. The history of the CZOR dates back more than 100 years to its establishment by the Vacuum Oil Company (a U.S. company and forerunner of Standard Oil). More than a century of continuous use of a sulfuric acid-based oil refining method by the CZOR has produced an estimated 120,000 tons of acidic, highly weathered, petroleum sludge. This waste has been deposited into three open, unlined process waste lagoons, 3 meters deep, now covering 3.8 hectares. Initial analysis indicated that the sludge was composed mainly of high molecular weight paraffinic and polynuclear aromatic hydrocarbons (PAHs). The overall objective of this full-scale demonstration project was to characterize, assess and remediate one of these lagoons. The remediation tested and evaluated a combination of U.S. and Polish-developed biological remediation technologies. Specifically, the goal of the demonstration was to reduce the environmental risk from PAH compounds in soil and to provide a green zone (grassy area) adjacent to the site boundary. The site was characterized using the DOE-developed Expedited Site Characterization (ESC) methodology. Based on the results of the ESC, a risk assessment was conducted using established U.S. procedures. Based on the results of the ESC and risk assessment, a 0.3-hectare site, the smallest of the waste lagoons, was selected for a modified aerobic biopile demonstration. This Executive Summary and the supporting report and appendices document the activities and results of this cooperative venture. Site CharacterizationSite Characterization was conducted in the summer of 1996 using DOE-developed Expedited Site Characterization (ESC). ESC makes use of direct push technologies (e.g., cone penetrometer), on-site chemical analysis and real-time data display and interpretation to conduct rapid and efficient site characterization. This ap...

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Acute nickel toxicity in electroplating workers who accidently ingested a solution of nickel sulfate and nickel chloride

Cited by 140 publications

References 11 publications

Infectious Nickel Tolerance: A Reciprocal Interplay of Tolerogenic APCs and T Suppressor Cells That Is Driven by Immunization

Infectious Nickel Tolerance: A Reciprocal Interplay of Tolerogenic APCs and T Suppressor Cells That Is Driven by Immunization

Comparative Metal Distribution in Scalp Hair of Pakistani and Irish Referents and Hypertensive Patients

Bioremediation of petroleum hydrocarbo-contaminated soils, comprehensive report, December 1999

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