Acute Nephropathy of Organotin Compounds

Lin, Jing; Hsueh, Swei

doi:10.1159/000168601

Cited by 29 publications

(10 citation statements)

References 3 publications

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“…Triphenyltin acetate is a TOT compound synthesized mainly for agricultural use; nonetheless, several episodes of occupational TPTA poisonings have been documented in humans (Manzo et al, 1981;Colosio et al, 1991;Lin and Hsueh, 1993;Lin et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Biochemical, ultrastructural and molecular characterization of the triphenyltin acetate (TPTA)-induced apoptosis in primary cultures of mouse thymocytes

et al. 2006

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Triphenyltin acetate (TPTA), a triorganotin compound used in agriculture as a biocide, is immunotoxic in vivo and in vitro. The present study was undertaken to ascertain whether apoptosis might play a role in the TPTA toxicity in vitro. Mouse thymocyte primary cultures were exposed to 0, 4 and 8 micromol/L TPTA; methyl prednisolone (1 micromol/L) was used as a positive control. Cell aliquots were harvested after 0, 1, 2, 4, and 8 h and the presence of early or late apoptotic phenomena was checked by (a) morphological investigations; (b) spectrophotometric quantification of fragmented DNA and agarose gel electrophoresis; (c) cell flow cytofluorometry, using an annexin V-FITC kit; and (d) detection of in situ apoptosis by a colorimetric detection kit (Titer-Tacs). TPTA cytotoxicity was also evaluated using the trypan blue dye exclusion test. Morphological investigation indicated apoptosis and/or necrosis. After 8 h of incubation, cells exposed to 4 micromol/L TPTA showed an increase in DNA fragmentation (on electrophoresis), which was confirmed by spectrophotometry (p < 0.05). Flow cytofluorometry pointed out an early (p < 0.05) increase of annexin V-positive (apoptotic) cells in TPTA-exposed flasks, whereas at least partly contradictory, results were obtained with the Titer-Tacs kit. Overall, these results provide evidence that TPTA, at low concentrations (4 micromol/L) induces early and late apoptotic phenomena, whereas cells exposed to the highest concentrations (8 micromol/L) are likely to undergo necrosis rather than apoptosis.

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Section: Discussionmentioning

confidence: 99%

Biochemical, ultrastructural and molecular characterization of the triphenyltin acetate (TPTA)-induced apoptosis in primary cultures of mouse thymocytes

et al. 2006

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“…However, TPTA is toxic to the CNS due to causing interstitial edema in white matter, and may cause pathological changes in cerebellar Purkinje's cells or limbic system structures [29,30]. In Taiwan, TPTA neurotoxicity has been noted in only three reports [25,26,31]. Suicidal attempt with molluscicidal agent was the main cause of intoxication in two of the five reported cases.…”

Section: The Agricultural Period (Post 1950s)mentioning

confidence: 99%

Occupational Neurotoxic Diseases in Taiwan

Liu

Huang

2012

Safety and Health at Work

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Occupational neurotoxic diseases have become increasingly common in Taiwan due to industrialization. Over the past 40 years, Taiwan has transformed from an agricultural society to an industrial society. The most common neurotoxic diseases also changed from organophosphate poisoning to heavy metal intoxication, and then to organic solvent and semiconductor agent poisoning. The nervous system is particularly vulnerable to toxic agents because of its high metabolic rate. Neurological manifestations may be transient or permanent, and may range from cognitive dysfunction, cerebellar ataxia, Parkinsonism, sensorimotor neuropathy and autonomic dysfunction to neuromuscular junction disorders. This study attempts to provide a review of the major outbreaks of occupational neurotoxins from 1968 to 2012. A total of 16 occupational neurotoxins, including organophosphates, toxic gases, heavy metals, organic solvents, and other toxic chemicals, were reviewed. Peer-reviewed articles related to the electrophysiology, neuroimaging, treatment and long-term follow up of these neurotoxic diseases were also obtained. The heavy metals involved consisted of lead, manganese, organic tin, mercury, arsenic, and thallium. The organic solvents included n-hexane, toluene, mixed solvents and carbon disulfide. Toxic gases such as carbon monoxide, and hydrogen sulfide were also included, along with toxic chemicals including polychlorinated biphenyls, tetramethylammonium hydroxide, organophosphates, and dimethylamine borane. In addition we attempted to correlate these events to the timeline of industrial development in Taiwan. By researching this topic, the hope is that it may help other developing countries to improve industrial hygiene and promote occupational safety and health care during the process of industrialization.

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“…Triorganotin groups are usually more toxic than dior mono-compounds of the same chain length. Tributyltin and triphenyltin compounds have embryotoxic, myotoxic, genotoxic and immunotoxic effects in mammals (Boyer, 1989;Kang et al, 1997;Chao et al, 1999;Cima et al, 2003;Wilson et al, 2004) and have been associated with occupational poisoning, hepatic injury, acute nephropathy, and mucous membrane irritation (Colosio et al, 1991;Lin and Hsueh, 1993;Wax and Dockstader, 1995). Derivatives of these compounds are known to induce imposex (the superimposition of male sex organs, penis and vas deferens, in females) in marine neogastropods and to cause developmental and reproductive toxicity in mammals by disrupting endocrine systems.…”

Section: Introductionmentioning

confidence: 99%