Acute N-(3,5-dichlorophenyl)succinimide nephrotoxicity in female Fischer 344 rats

Rankin, Gary O.; Beers, K. W.; Teets, Vonda J.; Nicoll, Derek W.; Anestis, Dianne K.; Brown, Patrick I.; Wang, Ruu-Tong

doi:10.1016/0300-483x(94)90117-1

Cited by 13 publications

(7 citation statements)

References 24 publications

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“…NDPS, NDHS, and 2-NDHSA induce nephrotoxicity in female Fischer 344 rats with ip doses as low as 0.2, 0.05, and 0.05 mmol/kg, respectively, while twice the dose of each compound is required to induce nephrotoxicity in male Fischer 344 rats (Rankin et al, 1988(Rankin et al, , 1994. In addition, female rats exhibit the initial renal lesion in the S 3 segment of the proximal tubule, but in male rats the initial renal lesion is observed in the S 1 and S 2 segments of the proximal tubule.…”

Section: Gender Differencesmentioning

confidence: 99%

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Mobile Telephones and Cancer—a Review of Epidemiological Evidence

Kundi

Mild²,

Hardell

et al. 2004

Journal of Toxicology and Environmental Health, Part B

135

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There is considerable public concern about possible long-term adverse health effects of mobile phones. While there is scientific controversy about long-term health effects of high-frequency electromagnetic fields lasting for at least 50 yr, the rise and success of mobile telecommunication made it necessary to investigate the problem more comprehensively and assess the possible risk cautiously because never before in history has a substantial proportion of the population been exposed to microwaves in the near field and at comparably high levels. Because the mostly localized exposure target region is the head, most epidemiological studies focus on brain tumors. Overall nine epidemiological studies have been published, four from the United States, two from Sweden, and one each from Denmark, Finland, and Germany. Seven studies were mainly on brain tumors, with one investigating in addition to brain tumors salivary gland cancer and another cancer of the hematopoietic and lymphatic tissues, and one examining intraocular melanoma. All studies have some methodological deficiencies: (1) too short duration of mobile phone use to be helpful in risk assessment, (2) exposure was not rigorously determined, and (3) there is a possibility of recall and response error in some studies. Nevertheless, all studies approaching reasonable latencies found an increased cancer risk associated with mobile phone use. Estimates of relative risk in these studies vary between 1.3 and 4.6 with highest overall risk for acoustic neuroma (3.5) and uveal melanoma (4.2), and there is evidence for enhanced cancer risk with increasing latency and duration of mobile phone use.

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Section: Gender Differencesmentioning

confidence: 99%

“…However, additional work is required to evaluate this possible mechanism for explaining the gender differences observed in NDPS nephrotoxicity. Rankin et al (1988Rankin et al ( , 1994 …”

Section: Gender Differencesmentioning

confidence: 99%

Mobile Telephones and Cancer—a Review of Epidemiological Evidence

Kundi

Mild²,

Hardell

et al. 2004

Journal of Toxicology and Environmental Health, Part B

135

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“…In contrast, both NDHS and 2-NDHSA are four times more potent than NDPS as nephrotoxicants in male rats based on changes in urine volume, increased proteinuria, increased kidney weight, elevations in BUN concentration and changes in renal morphology (Rankin et al, 1988;Hong et al, 1999a). In addition, female Fischer 344 rats are twice as sensitive to NDPS, NDHS and 2-NDHSA nephrotoxicity as male Fischer 344 rats, as evidenced by similar changes in the renal functional parameters described above and morphological changes, indicating that a gender difference exists for NDPS and NDPS metabolite-induced nephrotoxicity (Rankin et al, 1994;Hong et al, 1998; Table 1). The nephrotoxicity induced by NDPS and its metabolites has been recently reviewed (Rankin, 2004).…”

Section: Introductionmentioning

confidence: 70%

“…At the 0.4 mmol kg −1 dose of 3-NDHSA, both genders exhibited marked changes in the renal functional parameters measured. These results are in sharp contrast to NDPS, NDHS and 2-NDHSA where NDPS, NDHS and 2-NDHSA are clearly twice as potent as nephrotoxicants in female Fischer 344 rats as in male Fischer 344 rats (Table 1; Rankin et al, 1994;Hong et al, 1998).…”

Section: Discussionmentioning

confidence: 94%

“…On the following day, rats were administered an intraperitoneal (i.p.) injection of 3-NDHSA (0.1, 0.2 or 0.4 mmol kg −1 ) or vehicle (12.5% dimethylsulfoxide, DMSO, in corn oil, Rankin et al (1988Rankin et al ( , 1994Rankin et al ( , 2001bRankin et al ( , 2007. NC= no change from control; +/− = statistically signi¼cant increase, but minimal change; + = signi¼cant increase.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

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Nephrotoxicity induced by N‐(3,5‐dichlorophenyl)‐3‐hydroxysuccinamic acid in male and female Fischer 344 rats

Rankin

Hong

Anestis

2008

J of Applied Toxicology

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The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) is a more potent nephrotoxicant in female rats than in males. Similarly, nephrotoxicant NDPS metabolites studied to date in male and female rats have also demonstrated gender differences, being twice as potent as nephrotoxicants in females as in males. The purpose of this study was to examine the nephrotoxic potential of N-(3,5-dichlorophenyl)-3-hydroxysuccinimide (3-NDHSA) in male and female Fisher 344 rats to determine if gender differences in nephrotoxic potential also exist for this metabolite. Rats (four per group) were administered a single intraperitoneal (i.p.) injection of 3-NDHSA (0.1, 0.2 or 0.4 mmol kg(-1)) or vehicle, and renal function was monitored at 24 and 48 h. 3-NDHSA 0.1 mmol kg(-1) did not induce nephrotoxicity in male or female rats. In male rats, 3-NDHSA 0.2 mmol kg(-1) induced mild nephrotoxicity seen as diuresis and transient, mild proteinuria. However, 3-NDHSA 0.4 mmol kg(-1) induced marked nephrotoxicity. In female rats, 3-NDHSA 0.2 mmol kg(-1) induced mild nephrotoxicity, as evidenced by transient diuresis and proteinuria. As in males, 3-NDHSA 0.4 mmol kg(-1) induced marked nephrotoxicity. These results indicate that, unlike NDPS and other nephrotoxic NDPS metabolites, 3-NDHSA does not exhibit gender differences in nephrotoxic potential. In addition, in comparison with NDPS and other nephrotoxic NDPS metabolites, 3-NDHSA is a less potent nephrotoxicant that NDHS or 2-NDHSA and similar to NDPS in nephrotoxic potential in male rats.

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Gender differences in kidney function

Sabolić

Asif

Budach

et al. 2007

Pflugers Arch - Eur J Physiol

204

165

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Sex hormones influence the development of female (F) and male (M) specific traits and primarily affect the structure and function of gender-specific organs. Recent studies also indicated their important roles in regulating structure and/or function of nearly every tissue and organ in the mammalian body, including the kidneys, causing gender differences in a variety of characteristics. Clinical observations in humans and studies in experimental animals in vivo and in models in vitro have shown that renal structure and functions under various physiological, pharmacological, and toxicological conditions are different in M and F, and that these differences may be related to the sex-hormone-regulated expression and action of transporters in the apical and basolateral membrane of nephron epithelial cells. In this review we have collected published data on gender differences in renal functions, transporters and other related parameters, and present our own microarray data on messenger RNA expression for various transporters in the kidney cortex of M and F rats. With these data we would like to emphasize the importance of sex hormones in regulation of a variety of renal transport functions and to initiate further studies of gender-related differences in kidney structure and functions, which would enable us to better understand occurrence and development of various renal diseases, pharmacotherapy, and drug-induced nephrotoxicity in humans and animals.

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Acute N-(3,5-dichlorophenyl)succinimide nephrotoxicity in female Fischer 344 rats

Cited by 13 publications

References 24 publications

Mobile Telephones and Cancer—a Review of Epidemiological Evidence

Mobile Telephones and Cancer—a Review of Epidemiological Evidence

Nephrotoxicity induced by N‐(3,5‐dichlorophenyl)‐3‐hydroxysuccinamic acid in male and female Fischer 344 rats

Gender differences in kidney function

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