Acute myositis ossificans

Cvitanic, Oliver; Sedlak, Justin

doi:10.1007/bf00198078

Cited by 30 publications

(9 citation statements)

References 10 publications

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“…Enhancement after contrast administration can occur centrally in HO due to vascularity within the lesion, making the differentiation from sarcoma challenging at times. However, the developing zonal ossification pattern is important in distinguishing HO from a sarcoma, as identified by correlative radiograph or CT. As HO matures, rim enhancement after contrast administration is the predominant feature of HO lesions, which helps to differentiate HO from a soft‐tissue sarcoma …”

Section: Clinical Features Of Heterotopic Ossificationmentioning

confidence: 99%

Heterotopic Ossification: A Comprehensive Review

et al. 2019

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Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma and surgery. This comprehensive review seeks to synthesize the clinical, pathoetiologic, and basic biologic features of HO, including nongenetic and genetic forms. First, the clinical features, radiographic appearance, histopathologic diagnosis, and current methods of treatment are discussed. Next, current concepts regarding the mechanistic bases for HO are discussed, including the putative cell types responsible for HO formation, the inflammatory milieu and other prerequisite “niche” factors for HO initiation and propagation, and currently available animal models for the study of HO of this common and potentially devastating condition. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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Section: Clinical Features Of Heterotopic Ossificationmentioning

confidence: 99%

Heterotopic Ossification: A Comprehensive Review

et al. 2019

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“…Regarding gender, no sex predilection was found, as already stated by Nuovo et al [29]; although, in adulthood, MOC is more frequently described in males [8,12,24,30]. Most of the cases are adolescents, and only six patients are younger than 5 years.…”

Section: Discussionmentioning

confidence: 49%

Myositis ossificans circumscripta: a paediatric case and review of the literature

et al. 2009

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Myositis ossificans circumscripta (MOC), characterised by non-neoplastic heterotopic bone formation in soft tissue and skeletal muscle, is rare in children. At onset, it is difficult to distinguish MOC from a musculoskeletal infection or neoplasm, particularly in absence of trauma, and a biopsy is frequently required. We describe an 11-year-old boy with MOC in his thigh. At admission, minor local trauma was referred, and clinical examination revealed a tender and painful mass in the left thigh. Hypothesising a periarticular infection, a wide-spectrum antibiotic and an anti-inflammatory drug were given. The magnetic resonance imaging revealed an enlarged mass with marked enhancement of the lesion and a central, irregular non-enhanced area due to necrosis. After incisional biopsy, the histopathological examination found immature osteoblasts inside striated muscle fibres, as well as proliferating fibroblasts, which are all compatible with MOC, thereby ruling out infection or malignancy. The CT scan showed calcified deposits arranged in a ring, thus confirming MOC; a radiological follow-up was suggested to detect the lesion's maturation. Three months after diagnosis, surgical excision was performed. The post-operative period was uneventful. Six months later, the child was in good condition, with no signs of recurrence. In the literature, 57 paediatric cases have been described; most of these had an acute course, required excision and then had a favourable evolution. Our case study confirms the good prognosis of MOC and underlines how this benign condition should be considered in children presenting a tender and painful soft-tissue swelling.

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“…On routine MRI scan, the soft tissue mass may be indistinguishable from a sarcoma (4). MRI with gadolinium will show the lesion to have rim enhancement, a feature infrequently seen in other soft tissue masses (5).…”

Section: Discussionmentioning

confidence: 98%

Two Heads Better Than One? An Unusual Calcified Mass Discovered on Lateral C-Spine X-Ray Study

Barry

2009

The Journal of Emergency Medicine

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Acute myositis ossificans

Cited by 30 publications

References 10 publications

Heterotopic Ossification: A Comprehensive Review

Heterotopic Ossification: A Comprehensive Review

Myositis ossificans circumscripta: a paediatric case and review of the literature

Two Heads Better Than One? An Unusual Calcified Mass Discovered on Lateral C-Spine X-Ray Study

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