Acute myopia induced by topiramate: Report of a case and review of the literature

Bhattacharyya, Kalyan B; Basu, Suman

doi:10.4103/0028-3886.15074

Cited by 29 publications

(22 citation statements)

References 6 publications

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“…Se han publicado igualmente diferentes casos de miopía secundaria, tanto en adultos como en niños, en un rango de -2 a -9 dioptrías, también con más frecuencia en mujeres 23 , y dentro de los primeros días de tratamiento 11,24 . La presión intraocular puede ser normal, o acompañarse de hipertensión por cierre angular, y el cuadro es reversible dentro de los 3 a 4 días tras retirar el tratamiento 25 .…”

Section: B Miopia Secundariaunclassified

Topiramato: efectos secundarios a nivel ocular. Revisión a propósito de un caso

2011

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RESUMENPresentamos un caso de miopización bilateral aguda asociada a hipertensión ocular por cierre angular, secundario al inicio del tratamiento con topiramato vía oral. Revisión: Revisamos los principales efectos oculares secundarios al tratamiento con topiramato, tales como cierre angular agudo asociado a glaucoma o hipertensión ocular, miopización secundaria, o toxicidad retiniana. Los síntomas aparecen típicamente en las primeras semanas tras iniciar el tratamiento, o al duplicar la dosis. El cuadro se resuelve normalmente al suspender el fármaco. Conclusión: El topiramato es un fármaco utilizado principalmente como antiepiléptico si bien es ampliamente utilizado en otros tratamientos neurológicos y cuadros variados como cefaleas, alcoholismo, espasmos infantiles, neuralgias e incluso tratamiento de la obesidad y bulimia, entre otros. Dados los efectos secundarios descritos a nivel ocular, éstos deben ser conocidos por el oftalmólogo, y considerados por el mé-dico prescriptor, informando al paciente y a su familia al inicio del tratamiento.PALABRAS CLAVE: Topiramato, glaucoma secundario de ángulo cerrado, miopía sencundaria, toxicidad retiniana.Ocular side effects with topiramate: A case discussion and review of the literature SUMMARY Clinical case: We describe a case of acute bilateral ocular myopia associate to ocular hypertension by angle-closure secondary oral treatment with topiramate. Review: We review the main ocular effects related to the treatment with topiramate, such as angle-closure glaucoma, hyperten-Review: We review the main ocular effects related to the treatment with topiramate, such as angle-closure glaucoma, hypertension, secondary myopia, or retinal toxicity. Symptoms typically occur in the first weeks of the topiramate therapy, or when the dose is duplicate. The disease and symtoms dissapear when the medication is discontinued. Conclusion: The topiramato is a drug used mainly as anti-epileptic, and also in other variable neurological disorders as migraines, alcoholism, spasms, neuralgias and obesity and bulimia, among others. The secondary ocular effects must be known by the ophtalmologist and communicated to the patient and his family at the beginning of the treatment.KEY WORDS: Topiramate, angle closure glaucoma, secondary miopía, retinal toxicity. INTRODUCCIÓNEl Topiramato [sulfamato de 2,3:4,5-Bis-O-(1-metiletilideno)-beta-D-fructopiranosa] es un monosacárido sulfamato sustituido sintetizado en 1980 y aprobado en 1995 como medicamento anticonvulsivo utilizado para tratamiento de epilepsia tanto en niños como adultos. Entre otras indicaciones se encuentran principalmente el tratamiento del Síndrome de Lenox-Gastaut, prevención de la migraña, trastorno bipolar 1 , tratamiento de la obesidad (al reducir la ingesta incontrolada) y bulimia nerviosa 2 , alcoholismo 3 , trastornos por estrés postraumático 4 , espasmo infantil 5 , cefalea en racimos 6 , tabaquismo 7 , tratamiento del dolor neuropático, especialmente neuralgia del trigémino 8 y síndrome piernas inquietas 9 . Tras su administ...

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Section: B Miopia Secundariaunclassified

Topiramato: efectos secundarios a nivel ocular. Revisión a propósito de un caso

2011

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“…Topiramate was immediately withdrawn and diuretics begun to reduce the intraocular pressure, and the patient's visual acuity returned to normal on the 5th day (Bhattacharyya & Basu 2005). Other cases of acute glaucoma with topiramate have been reported (Fraunfelder et al 2004), and the potential occurrence of this adverse reaction is noted in the prescribing information (Anon 2005a) and on the manufacturer's website (http://www.topamax.com/utilities/safety_info.jsp).…”

Section: Tolerabilitymentioning

confidence: 99%

“…A case report from India described the occurrence of acute myopia and elevated intra-ocular pressure leading to temporary loss of vision in a 40-year old woman with migraine, 4 days after beginning treatment with topiramate 25 mg/day and flunarizine 5 mg/day (Bhattacharyya & Basu 2005). Topiramate was immediately withdrawn and diuretics begun to reduce the intraocular pressure, and the patient's visual acuity returned to normal on the 5th day (Bhattacharyya & Basu 2005).…”

Section: Tolerabilitymentioning

confidence: 99%

Topiramate: the evidence for its therapeutic value in the prevention of migraine

Nadin¹

2005

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Introduction: Preventive therapy is recommended in patients with migraines frequent and/or severe enough to interfere with daily life, and/or with an inadequate response to acute therapy (26-43% of patients with migraine in a recent US survey). Preventive treatments include beta blockers, amitriptyline, and antiepileptics (sodium valproate, gabapentin), but these may have significant adverse effects and are contraindicated in some patients. Topiramate is an antiepileptic recently approved for prevention of migraine.

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“…Recentemente, tem sido usado no manejo de migrânea, síndrome depressiva, dor neuropática e obesidade, em detrimento de seu uso para o controle da epilepsia, visto que é prescrito apenas em casos refratários (1) . Alguns relatos têm sido publicados relacionando-os a efeitos oftalmológicos adversos.…”

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Miopia aguda induzida por topiramato: relato de dois casos

Sgrott¹,

Silva²,

Hagemann³

et al. 2011

Rev. bras.oftalmol.

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RESUMOA miopia aguda pode ser desencadeada pelo uso de medicações sistêmicas, dentre elas, o anticonvulsivante topiramato. Este trabalho descreve dois casos de pacientes jovens com quadro agudo bilateral de miopia induzida por terapia com topiramato para controle de síndrome depressiva, fazendo relação com casos semelhantes descritos na literatura e revisão bibliográfica pertinente.Descritores: Miopia/induzido quimicamente; Anticonvulsivantes/efeitos adversos; Relatos de casos Recebido para publicação em: 26/10/2009 -Aceito para publicação em 28/6/2011 ABSTRACT

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Acute myopia induced by topiramate: Report of a case and review of the literature

Cited by 29 publications

References 6 publications

Topiramato: efectos secundarios a nivel ocular. Revisión a propósito de un caso

Topiramato: efectos secundarios a nivel ocular. Revisión a propósito de un caso

Topiramate: the evidence for its therapeutic value in the prevention of migraine

Miopia aguda induzida por topiramato: relato de dois casos

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