Acute Myocardial Ischemia in Adults Secondary to Missed Kawasaki Disease in Childhood

Rizk, Sherif; Said, Galal El; Daniels, Lori B.; Burns, Jane C.; Said, Howaida El; Sorour, Khaled; Gharib, Soliman; Gordon, John B.

doi:10.1016/s0735-1097(14)60128-5

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…Increasing numbers of young adults in the United States and Japan present with myocardial infarction, congestive heart failure, arrhythmias, and sudden death as late sequelae of missed KD . Coronary angiography reveals aneurysms attributable to antecedent KD in 5%–7% of adults < 40 years of age evaluated for suspected myocardial ischemia . Unless clinicians consistently identify children at risk for KD from clinical features, children will experience delays in diagnosis and suffer potentially preventable morbidity and mortality.…”

Section: Background and Importancementioning

confidence: 99%

Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes

Doan

Maehara

Chaparro

et al. 2016

Academic Emergency Medicine

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Objective Delayed diagnosis of Kawasaki disease (KD) may lead to serious cardiac complications. We sought to create and test the performance of a natural language processing (NLP) tool, the KD-NLP, in the identification of emergency department (ED) patients for whom the diagnosis of KD should be considered. Methods We developed an NLP tool that recognizes the KD diagnostic criteria based on standard clinical terms and medical word usage using 22 pediatric ED notes augmented by Unified Medical Language System vocabulary. With high suspicion for KD defined as fever and three or more KD clinical signs, KD-NLP was applied to 253 ED notes from children ultimately diagnosed with either KD or another febrile illness. We evaluated KD-NLP performance against ED notes manually reviewed by clinicians and compared the results to a simple keyword search. Results KD-NLP identified high-suspicion patients with a sensitivity of 93.6% and specificity of 77.5% compared to notes manually reviewed by clinicians. The tool outperformed a simple keyword search (sensitivity = 41.0%; specificity = 76.3%). Conclusions KD-NLP showed comparable performance to clinician manual chart review for identification of pediatric ED patients with a high suspicion for KD. This tool could be incorporated into the ED electronic health record system to alert providers to consider the diagnosis of KD. KD-NLP could serve as a model for decision support for other conditions in the ED.

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Section: Background and Importancementioning

confidence: 99%

Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes

Doan

Maehara

Chaparro

et al. 2016

Academic Emergency Medicine

Self Cite

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“…Kawasaki disease (KD) is an acute febrile illness and systemic vasculitis of unknown etiology that predominantly afflicts young children and causes coronary artery aneurysms (CAAs) or abnormalities that can ultimately lead to ischemic heart disease, myocardial infarction, and even death (1)(2)(3)(4)(5)(6)(7). KD is the leading cause of acquired heart disease among children in the USA and developed countries (3).…”

Section: Introductionmentioning

confidence: 99%

Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis

et al. 2019

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“…A reason of shortage of incidence reports from this region could be due to the lower socioeconomic status and a lack of census data for children < 5 years of age. A study from Egypt reported coronary aneurysms denoting missed childhood KD cases when they reviewed a series of 580 patients ≤ 40 years of age presenting with symptoms of coronary artery ischemia [34]. Also, Agha et al reported two cases with incomplete KD in children < 5 years old complicated with coronary aneurysm [35].…”

Section: Kd In the Middle East And Sub-saharan Africamentioning

confidence: 99%

Kawasaki Disease: Global Burden and Genetic Background

et al. 2020

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Kawasaki disease (KD) is a childhood vasculitides associated with serious coronary artery lesions. It is the most common cause of pediatric acquired heart disease in developed countries, and is increasingly reported from many rapidly industrializing developing countries. The incidence varies widely among different nations and is highest in North-East Asian countries, where almost 1 in 100 children in Japan having the disease by age of 5, where the lowest incidence reported in sub-Saharan Africa. The etiology of KD is still uncertain; interaction between a genetic predisposition and several environmental and immunological factors has been hypothesized. Several susceptibility genes were identified to be associated with the development of KD and increased risk of coronary artery lesions. Gene-gene associations and alteration of deoxyribonucleic acid (DNA) methylation are also found to play key roles in the pathogenesis and prognosis of KD. This article will focus on the global epidemiological patterns of KD, and the currently known genetic predisposition. Global EpidemiologyKD has been documented in more than 60 countries and cross all ethnicities [4,17] (Fig. 1, [2]). The incidence of KD is in-

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Acute Myocardial Ischemia in Adults Secondary to Missed Kawasaki Disease in Childhood

Cited by 6 publications

References 12 publications

Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes

Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes

Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis

Kawasaki Disease: Global Burden and Genetic Background

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