Acute myocardial infarction. Prognostic value of white blood cell count and blood glucose level

Modan, Baruch; Schor, Stanley S.; Shani, Michal

doi:10.1001/jama.233.3.266

Cited by 20 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This was unrecognized at the time, presumably due to the prominence at this initial presentation of vomiting, fever, and leukocytosis, which led to a diagnosis of gastroenteritis. Vomiting, fever, and leukocytosis, however, are not uncommon with myocardial infarction and are consistent with the initial diagnosis [6][7][8]. The persistent fever and leukocytosis beyond 1 wk, however, suggest the possibility of pericarditis of myocardial infarction, and this is also suggested by his chest pain with recumbency.…”

Section: Discussionsupporting

confidence: 65%

Subacute ventricular free-wall rupture presenting as tamponade without frank hemopericardium

Tate

Lawton

DeGent

et al. 1998

Cathet. Cardiovasc. Diagn.

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 65%

Subacute ventricular free-wall rupture presenting as tamponade without frank hemopericardium

Tate

Lawton

DeGent

et al. 1998

Cathet. Cardiovasc. Diagn.

View full text Add to dashboard Cite

“…Whereas glycemia following a MI is a known risk factor for death, most studies have concluded that hyperglycemia at the time MI occurs either contributes to the severity of the event or is induced by the event (11,12,43,44). Previous studies designed to resolve this have been small and produced conflicting results (44,45).…”

Section: Risk Of Fatal MI In T Years ϸ (Risk Of Mi Over T Years) ϫ (Cmentioning

confidence: 99%

Risk Factors for Myocardial Infarction Case Fatality and Stroke Case Fatality in Type 2 Diabetes

et al. 2004

View full text Add to dashboard Cite

OBJECTIVE -Patients with diabetes have a higher case fatality rate in myocardial infarction (MI) or stroke than those without diabetes: that is, MI and stroke are more often fatal if diabetes is present. We investigated whether the risk of MI or stroke being fatal in type 2 diabetes can be estimated using information available around the time diabetes is diagnosed.RESEARCH DESIGN AND METHODS -Analyses were based on 674 cases of MI (351 fatal) that occurred in 597 of 5,102 U.K. Prospective Diabetes Study (UKPDS) patients for whom covariate data were available during a median follow-up of 7 years. Multivariate logistic regression was used to examine differences in risk factors, measured within 2 years of diagnosis of diabetes, between fatal and nonfatal MI. Similar analyses were performed for 234 strokes (48 fatal) that occurred in 199 patients.RESULTS -Patients with fatal MI had higher HbA 1c than those with nonfatal MI (odds ratio 1.17 per 1% HbA 1c , P ϭ 0.014). Patients with fatal stroke had higher HbA 1c than those with nonfatal stroke (odds ratio 1.37 per 1% HbA 1c , P ϭ 0.007). Other risk factors for MI case fatality included increased age, blood pressure, and urine albumin level.CONCLUSIONS -The risk of MI or stroke being fatal in type 2 diabetes is associated with risk factors, including HbA 1c , measured many years before onset of MI or stroke. Equations have been added to the UKPDS Risk Engine to estimate likely case fatality rates in MI and stroke. Diabetes Care 27:201-207, 2004M yocardial infarction (MI) and stroke are more common among people with diabetes than those without (1-3). Diabetes is also a risk factor for MI case fatality: that is, MI is more often fatal in people with diabetes compared with MI in those without diabetes (4 -7). Hyperglycemia has been shown to be a risk factor for MI case fatality in people with and without diabetes (4,8 -11), but studies have been limited mainly to risk factor measurements taken after admission to hospital for MI (4,8 -10). Some authors have regarded hyperglycemia as a metabolic consequence of severe MI rather than a cause (12-14), and it is known that insulin therapy to reduce blood glucose levels can improve prognosis after MI in patients with diabetes (15).We have used data from the U.K. Prospective Diabetes Study (UKPDS) to examine differences in risk factors measured during the first 2 years after diagnosis of diabetes between those with fatal MI and those with nonfatal MI. We also examine differences between those with fatal stroke and nonfatal stroke. The prospective design of the UKPDS allows this analysis to include all cases of MI and stroke, not just those surviving to reach hospital, and permits the assessment of risk factors measured many years before the MI or stroke occurs. The UKPDS Risk Engine is a risk calculator specific to type 2 diabetes that can be used to estimate the risk of MI (16) or stroke (17) occurring within a given time period. The present analysis adds to the risk engine equations for MI and stroke case fatality to enable es...

show abstract

“…Epidemiological studies have demonstrated that hyperglycemia is an independent risk factor for poor prognosis in AMI patients, whether or not having diabetes history [5]. The prognostic value of the blood glucose in AMI patients was first suggested in 1975 [6], numerous studies have researched the correlation between hyperglycemia and adverse outcome in AMI patients since then. Hyperglycemia on admission is associated with higher mortality incidence, larger infarct size, impaired left ventricular function and poor clinical prognosis after AMI [5], Researches demonstrated a linear correlation between blood glucose on admission and AMI mortality.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of random blood glucose versus fasting blood glucose on in-hospital adverse events in patients with ST-segment elevation acute myocardial infarction

Qin

Yan

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background: We aim to find out the relationship between random blood glucose (RBG), fasting blood glucose (FBG) and in-hospital adverse events in ST-segment elevation acute myocardial infarction (STEMI) patients. We evaluate and compare the predictive value of RBG and FBG on in-hospital adverse events, and give an appropriate cutoff value of RBG and FBG. Method: A retrospective study enrolled 958 consecutive AMI patients undergoing emergency coronary angiography at Zhongda Hospital were enrolled from January 1, 2016, to December 31, 2018 was performed. RBG and FBG, baseline data and adverse events were recorded. Major adverse cardiovascular and cerebrovascular events (MACCE) were defined as death, nonfatal recurrent myocardial infarction and stroke. Other adverse events included malignant arrhythmia, cardiac shock and hemorrhage. Patients with RBG > 11.1 mmol/L were divided into elevated RBG group. Patients with FBG > 6.1 mmol/L were divided into elevated FBG group. The incidence of in-hospital adverse events were compared in elevated RBG/FBG group and the control group. ROC curve was used to evaluate the predictive value of RBG and FBG on in-hospital adverse events. Result: The incidence of death, hemorrhage, cardiac shock and malignant arrhythmia significantly increases in elevated RBG and FBG group. Binary logistic regression showed that age, hypertension, diabetes, FBG and RBG were independent risk factors for in-hospital adverse events in STEMI patients. The AUC and 95% CI of RBG and FBG in predicting death of AMI patients were 0.789, 0.759~0.816; 0.810, 0.783~0.835, respectively. The cutoff values were 13.82 and 7.35 mmol/L. RBG and FBG also had fine predictive value on cardiac shock and malignant arrhythmia, no statistical difference was found in the predictive value on in-hospital adverse events (P = 0.462, P = 0.570, P = 0.694). Conclusion: Incidence of in-hospital adverse events significantly increases in AMI patients combined with elevated RBG or FBG. Both RBG and FBG were independent risk factors for in-hospital adverse events, they had good value on predicting in-hospital adverse events and there was no statistical difference in their predictive value.

show abstract

Acute myocardial infarction. Prognostic value of white blood cell count and blood glucose level

Cited by 20 publications

References 13 publications

Subacute ventricular free-wall rupture presenting as tamponade without frank hemopericardium

Subacute ventricular free-wall rupture presenting as tamponade without frank hemopericardium

Risk Factors for Myocardial Infarction Case Fatality and Stroke Case Fatality in Type 2 Diabetes

Predictive value of random blood glucose versus fasting blood glucose on in-hospital adverse events in patients with ST-segment elevation acute myocardial infarction

Contact Info

Product

Resources

About