Acute Myocardial Infarction Mortality Rates and Trends in Romania between 1994 and 2017

Abstract

Introduction: The current study aimed to assess recent acute myocardial infarction (AMI) mortality rates and trends in Romania between 1994 and 2017. This dataset is a necessity in the context of the current improvement of emergency protocols, medical addressability, and modernization of hospital infrastructure. Materials and Methods: The study is a retrospective analysis of an anonymized mortality database containing all deaths registered in Romania during 1994–2017. AMI crude mortality rates (CMR) and age-standardized mortality rates (ASMR) were calculated using the European Standard Population. Poisson regression was used for calculating the annual percentage change (APC) in mortality, subsequently used to make mortality predictions through the year 2030. Results: There were 197,152 AMI deaths in women (39.3% of total AMI), and 304,644 (60.7%) in men. Mortality rates were higher in men as compared with women for the entire time covered by the study. Based on the 1994–2017 ASMR dynamics, predictions for the year 2030 showed an overall AMI ASMR of 70.9 (95% CI 69.9–71.9), with gender analysis showing 46.8 (95% CI 45.8–47.9) in women and 104.1 (95% CI 102.3–105.8) in men. Conclusion: Acute myocardial infarction age-standardized mortality rates decreased significantly in Romania between 1994 and 2017 in close correlation to the implementation of national healthcare programs.

Acute myocardial infarction trends in the population of the Nišava District

“…The highest rates among men were recorded in Ukraine (656.3) and Republic of Moldova (597.0), and the lowest rates were found in France (47.3) and Portugal (55.0). Similarly, the lowest rates in women were recorded in France and Spain (17.5 and 26.8, respectively) while the highest rates were noticed in the Republic of Moldova and Ukraine (424.3 and 391.5, respectively) (18).…”

Klotho overexpression suppresses apoptosis by regulating the Hsp70/Akt/Bad pathway in H9c2(2-1) cells

“…A previous study indicated that klotho inhibited angiotensin II-induced cardiomyocyte hypertrophy by suppressing the angiotensin II type I receptor/β-catenin pathway ( 1 ). Another group found that klotho suppressed cardiomyocyte apoptosis in mice with stress-induced cardiac injury by downregulating endoplasmic reticulum stress ( 2 ). In the present study, klotho and HSP70 were found to co-localize in the cell cytoplasm, and klotho overexpression was accompanied by HSP70 upregulation.…”

“…Globally, acute myocardial infarction (AMI) is associated with high mortality and morbidity rates ( 1 , 2 ). Reperfusion therapy is the most effective way to treat this disease in a clinical setting ( 3 ).…”

Clinical Overview of Myocardial Infarction WithoutObstructive Coronary Artey Disease (MINOCA)

“…Worldwide, acute myocardial infarction (AMI) is associated with high mortality [ 1 , 2 ]. The management of AMI has evolved over the last few decades.…”