Acute Myocardial Infarction in Young Japanese Adults  Clinical Manifestations and In-Hospital Outcome

Shiraishi, Jun; Kohno, Yoshio; Yamaguchi, Shinichiro; Arihara, Masayasu; Hadase, Mitsuyoshi; Hyogo, Masayuki; Yagi, Takakazu; Shima, Takatomo; Sawada, Takahisa; Tatsumi, Tomohide; Azuma, Akihiro; Matsubara, Hiroaki

doi:10.1253/circj.69.1454

Cited by 43 publications

(48 citation statements)

References 27 publications

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“…1,3,4,7,8,16,17) Our study results were in accordance with these previous studies. Although being overweight has not been considered to be a definite risk factor for MI, it has been suggested to be a risk factor for MI in young populations.…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies reported that the prevalence of Killip I and single vessel disease in young groups was higher than in non-young groups. 1,4,16,17) Our study results were similar to these studies. The dominance of Killip I and single vessel disease may be a reason for the better outcomes in young AMI.…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies reported that the prevalence of diabetes mellitus in young patients was lower than that in non-young patients. 1,4,16,17) In our study, the prevalence of diabetes mellitus was not different between the groups, and the prevalence of diabetes mellitus in the young group was slightly higher compared to previous studies. 1,3,4,16,17) In the present study, single marital status was more frequently observed in the young group.…”

Section: Discussioncontrasting

confidence: 78%

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Clinical Features of Myocardial Infarction in Young Japanese Patients

et al. 2013

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SummaryClinical features and outcomes of acute myocardial infarction (AMI) in the young have been poorly investigated. The aim of this study was to investigate the clinical features and hospital outcomes of AMI in young Japanese. We conducted a case-control study. A total of 53 consecutive AMI patients whose age was ≤ 45 years old were assigned to the young group and 106 AMI patients whose age was > 45 years old were assigned to the non-young group. We compared the clinical features and hospital outcomes between the two groups. Compared with the non-young group, the young group was associated with male sex, hyperlipidemia, current smoking, being overweight, single vessel disease, and Killip class I on admission. There were no differences in the length of hospital stay or major adverse cardiac events between the groups. However, mortality and ventricular rupture were slightly lower in the young. In conclusion, young AMI patients had clinical characteristics different to those of the non-young patients. Compared to non-young patients, modifiable risk factors such as smoking, hyperlipidemia, and being overweight were associated with young AMI patients. (Int Heart J 2013; 54: 123-128) Key words: Angioplasty, Age, Ischemic heart disease A lthough the incidence of coronary artery disease in the young is still lower than that in the non-young, 1,2) coronary artery disease in the young has been increased recently. The clinical features and outcomes of acute myocardial infarction (AMI) in the young are considered to be different from those in the non-young. [1][2][3][4][5][6][7][8][9] As diet patterns and lifestyles in the young are different from the non-young, 10,11) specific and unique considerations are needed for young AMI patients. It is important to elucidate the clinical features and outcomes of AMI in young patients. We conducted a case-control study to elucidate the clinical features of AMI in young patients. MethodsCases and controls: We identified acute myocardial infarction patients from the hospital records of our medical center from January 2007 to March 2012. A diagnosis of AMI consisted of elevation of creatine kinase (at least 2-fold above the normal upper limit), and the presence of 1 of the following 2 criteria; (1) persistent chest pain or (2) ST-segment elevation or depression in the 12-lead electrocardiogram compatible with AMI. During the study period, 53 consecutive AMI patients whose age was ≤ 45 years old were assigned to the young group (Case group). 8,12) The control patients were selected from our AMI patients whose age was > 45 years old during the same study period. We designed the study so the ratio of cases to controls would be 1 to 2. To minimize the selection bias, consecutive AMI patients whose age was > 45 years old were assigned to the non-young group (Control group). In addition, to minimize any bias related to the therapeutic strategy for AMI, consecutive selection was conducted for each year. This study was approved by the institutional review board. PCI procedures: PCI was p...

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 78%

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Clinical Features of Myocardial Infarction in Young Japanese Patients

et al. 2013

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“…This difference has shown in other studies of IHD were seen less than non-elderly group, too [13]- [15]. In other countries, this is confirmed [16]- [19]. That might be associated with other risk factors which can show a familial distribution, such as smoking, life style, dyslipidemia, or genetic similarities among families.…”

Section: Discussionsupporting

confidence: 50%

Risk Factors of First Acute Myocardial Infarction: Comparison of Elderly and Non-Elderly: A 24-Year Study

Dabiran¹,

Manesh²,

Khajehnasiri³

2015

AAR

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Although risk factors of Ischemic Heart Disease (IHD) are well known, knowledge about the distribution of these risk factors in different subgroups of patients can be used for designing preventive programs. The aim of this study was to assess differences of prevalence of IHD risk factors in elderly and non-elderly patients in their first Acute Myocardial Infarction (AMI). In this retrospective study, elderly (age > 65; n = 1060) and non-elderly (age ≤ 65; n = 2228) patients with first AMI who were admitted into four teaching hospitals in Tehran between 1982 and 2005 were recruited. Risk factors containing male gender, systolic and diastolic hypertension (HTN), diabetes, hypertriglyceridemia, hypercholesterolemia, smoking and family history of IHD were compared between the two groups. Among different risk factors, diabetes and systolic HTN were more common in elderly than their non-elderly counterparts, and male gender, smoking, family history of IHD and dyslipidemia were more common in non-elderly patients than elderly ones (p < 0.05 for all comparison). Diastolic HTN showed no significant difference between the two groups. Findings of this study, stating difference of prevalence of risk factors in two elderly and non-elderly groups, can be used by health policy makers to conduct preventive programs for AMI in this country.

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“…The AMI-Kyoto Multi-Center Risk Study, a large multicenter observational study in which 16 collaborating hospitals in Kyoto Prefecture have collected demographic, procedural, and outcome data on AMI patients, was established in 2000 in order to analyze this data and establish an emergency hospital network for heart diseases in Kyoto. [5][6][7] The purpose of the present study was therefore to compare clinical backgrounds, in-hospital prognosis, and determinants of in-hospital outcome in primary PCI-treated AMI patients requiring IABP/PCPS with those of primary PCI-treated AMI patients without IABP/PCPS, using data from the AMI-Kyoto Multi-Center Risk Study.…”

Section: Prognostic Predictors Of Ami With Iabp/pcpsmentioning

confidence: 99%

Predictors of In-Hospital Prognosis After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction Requiring Mechanical Support Devices

Shiraishi

Kohno

Sawada

et al. 2010

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp rimary percutaneous coronary intervention (PCI) is now established as a first-line therapeutic strategy for patients with acute myocardial infarction (AMI), and accumulating evidence has shown that primary PCI can improve the prognosis in AMI patients suffering from cardiogenic shock. 1-4 In addition to the interventional treatment, mechanical assist devices such as intra-aortic balloon pumping (IABP) and percutaneous cardiopulmonary support (PCPS) are indispensable for AMI patients complicated with cardiogenic shock, refractory malignant arrhythmia, advanced heart failure, or failed reperfusion. Thus, the AMI patients requiring mechanical support devices are considered as a subgroup of high-risk AMI patients with high in-hospital morbidity and mortality. Recently, we have already demonstrated that repeat-AMI patients undergoing primary PCI, a subgroup of high-risk patients with AMI had a significantly higher in-hospital mortality rate than first-AMI patients, and determinants of in-hospital outcome in recurrent-AMI patients undergoing primary PCI were different from those in first-AMI patients. Background: Predictors of in-hospital outcome after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) requiring mechanical support devices such as intra-aortic balloon pumping (IABP) and/or percutaneous cardiopulmonary support (PCPS) remain unclear.

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Acute Myocardial Infarction in Young Japanese Adults Clinical Manifestations and In-Hospital Outcome

Cited by 43 publications

References 27 publications

Clinical Features of Myocardial Infarction in Young Japanese Patients

Clinical Features of Myocardial Infarction in Young Japanese Patients

Risk Factors of First Acute Myocardial Infarction: Comparison of Elderly and Non-Elderly: A 24-Year Study

Predictors of In-Hospital Prognosis After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction Requiring Mechanical Support Devices

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