Abstract:Recent reports (1-4) of adverse cardiac events following the administration of sumatriptan have raised concern among doctors and patients. The following case report underlines the difficulties in establishing a causal association between drugs and acute medical events. A 44-year-old Dutch woman suddenly developed chest pain and collapsed while on holiday in Belgium. She was found in ventricular fibrillation when the ambulance staff arrived and received several DC shocks. She had an inferior postero-lateral myo… Show more
“…Sumatriptan is a less potent vasoconstrictor than serotonin. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Some of the patients involved had at least 1 vascular risk factor. 7 There have been case reports of myocardial infarction (MI) occurring in temporal association with triptan use in adults with no previous history of coronary artery disease.…”
“…Sumatriptan is a less potent vasoconstrictor than serotonin. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Some of the patients involved had at least 1 vascular risk factor. 7 There have been case reports of myocardial infarction (MI) occurring in temporal association with triptan use in adults with no previous history of coronary artery disease.…”
This study provides Class I evidence that in ED patients with acute migraine, IV valproate is inferior to metoclopramide or ketorolac in improving headache outcomes.
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