Acute Myocardial Infarction Due to Coronary Occlusion Caused by a Metastatic Cardiac Tumor Arising from Squamous Cell Lung Cancer: An Evaluation with Three-dimensional Transthoracic Echocardiography

Kuramoto, Masafumi; Okada, Masako; Saeki, Hajime; Yoshida, Yasuyuki; Hasegawa, Shin

doi:10.2169/internalmedicine.7580-21

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Involvement of the coronary arteries has rarely been reported in the literature. Different mechanisms of causing obstructive coronary artery disease were reported, including direct invasion of coronaries with metastatic lesions or mechanical obstruction at the ostium causing recurrent angina [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Cardiac Sarcoma: Angiosarcoma Compressing the Right Coronary Artery

Mubder¹,

Pour-Ghaz²,

Al-Taweel³

et al. 2023

Cureus

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Cardiac tumors are uncommon and can be classified as either primary benign, primary malignant, or metastatic. Cardiac tumors have a wide range of presentations, which can lead to delays in diagnosis and treatment. Primary cardiac tumors can also affect nearby structures, and there have been a few reported cases of coronary artery involvement with various underlying causes. In this case report, we describe a patient with a primary cardiac sarcoma (angiosarcoma) that had spread to other parts of the body and caused occlusion of the right coronary artery.

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Section: Discussionmentioning

confidence: 99%

Primary Cardiac Sarcoma: Angiosarcoma Compressing the Right Coronary Artery

Mubder¹,

Pour-Ghaz²,

Al-Taweel³

et al. 2023

Cureus

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“…Several mechanisms of MI in cancer patients have been proposed [ 14 , 15 , 16 ]. The metastases of lung cancer to the heart can block coronary arteries directly, causing acute myocardial infarctions.…”

Section: Discussionmentioning

confidence: 99%

“…There is a possibility that such a situation does exist, although it is relatively rare. In the literature, several cases of myocardial infarction associated with metastatic lung cancer have been reported [ 14 , 15 , 16 ]. As the patient we describe here did not have a diagnosed metastatic disease, we may suspect that COVID-19 and the accumulation of the patient’s other traditional risk factors (smoking, diabetes type 2, hyperlipidaemia, and hypertension) could have contributed to the MI.…”

Section: Discussionmentioning

confidence: 99%

A COVID-19 Diagnosis Like an Avalanche Triggers a Series of Adverse Events but Saves a Life in the End

Iwański

Sokołowska

Wańczura³

et al. 2023

Healthcare

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Patients diagnosed with cancer are less frequently covered by preventive measures for cardiovascular diseases. The frequent co-occurrence of these diseases makes it necessary to apply parallel diagnostics and cardiological treatment with anti-cancer therapy. Frequently. multidisciplinary team discussions are needed. Case report: We present a case of a 73-year-old former smoker with hyperlipidemia, type 2 diabetes, and arterial hypertension, after a partial right nephrectomy in 2005 due to kidney cancer, diagnosed with SARS-CoV-2 infection in April 2022. Subsequent chest imaging showed a 20 mm focal lesion in the left lung further classified as a small-cell neuroendocrine carcinoma. Unexpectedly, the patient was hospitalized due to ST-segment elevation inferior left ventricular (LV) myocardial infarction. It was treated successfully with percutaneous coronary angioplasty (PCI) of the circumflex and first marginal artery with drug-eluting stent (DES) implantation. One day later, PCI of the left anterior artery was performed with two DES implantation; however, heart failure (HF) with a reduced left ventricle ejection fraction of 30% was diagnosed. One month later, the patient required hospitalization again due to HF decompensation, and cardiological treatment was optimized with flozin in addition to standard HF therapy. Subsequently, after cardiological approval the patient qualified for chemotherapy with the cisplatin–etoposide regimen. Therapy was continued for 6 months without HF decompensation and significant deterioration in renal function. After that, the patient underwent radical radiotherapy. Follow-up chest computed tomography scans showed regression of the neoplastic lesion. Conclusions: The coincidence of newly recognized cancer and inflammatory disease might contribute to and provoke serious cardiological events. To reduce the risk of cardiovascular complications, periodic cardiological surveillance and optimal pharmacotherapy are required.

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“…Its treatment mainly includes thrombolysis, surgery, etc. Reperfusion can cause damage to the myocardium, including inflammation, apoptosis, oxidative stress injury, and calcium overload (Kuramoto et al, 2021). Therefore, it is necessary to further elucidate the mechanisms and develop effective drugs for the treatment of MI.…”

Section: Discussionmentioning

confidence: 99%

Ligustrazine enhances the protective effect of remifentanil on myocardial ischemia-reperfusion injury by regulating miR-211/USP47 pathway

Li¹,

Xia

2022

Qual. Assur. Saf. Crops Foods

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Purpose: To assess the effects of ligustrazine on the progression of hypoxia-reoxygenation (H/R), and explore the possible role of miR-211 in myocardial ischemia-reperfusion (I/R) injury and identify its potential targeting gene. Methods: The level of miR-211 in H/R-induced cells was detected by quantitative polymerase chain reaction. CCK-8, flow cytometry (FCM), and Western blot assays were performed to examine the effect of miR-211 and USP47 on the role of remifentanil against H/R injury. Bioinformatic analysis and luciferase and Western blot assays were performed to identify and verify the potential target of miR-211. CCK-8 and FCM assays were performed to detect the mechanism of ligustrazine and miR-211 in the protection of remifentanil against H/R-induced cells. Results: Ligustrazine enhanced the effect of remifentanil on H/R-induced cardiomyocytes. MiR-211 enhanced the protective effect of remifentanil against H/R injury. Down-regulation of USP47 enhanced the protective effect of remifentanil against H/R injury. Ligustrazine enhanced the protective effect of remifentanil against H/R injury through miR-211/USP47 pathway. Conclusion: Ligustrazine enhanced the protective effect of remifentanil on myocardial I/R injury by regulating miR-211/USP47 pathway.

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Acute Myocardial Infarction Due to Coronary Occlusion Caused by a Metastatic Cardiac Tumor Arising from Squamous Cell Lung Cancer: An Evaluation with Three-dimensional Transthoracic Echocardiography

Cited by 5 publications

References 7 publications

Primary Cardiac Sarcoma: Angiosarcoma Compressing the Right Coronary Artery

Primary Cardiac Sarcoma: Angiosarcoma Compressing the Right Coronary Artery

A COVID-19 Diagnosis Like an Avalanche Triggers a Series of Adverse Events but Saves a Life in the End

Ligustrazine enhances the protective effect of remifentanil on myocardial ischemia-reperfusion injury by regulating miR-211/USP47 pathway

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