Acute myocardial infarction and heart failure: Role of apoptosis

Abbate, Antonio; Bussani, Rossana; Amin, Mitesh S.; Vetrovec, George W.; Baldi, Alfonso

doi:10.1016/j.biocel.2006.04.010

Cited by 151 publications

(108 citation statements)

References 28 publications

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“…Molecular imaging of this process in clinical practice may therefore enhance diagnosis, monitoring of disease course, and monitoring of the efficacy of treatment for a wide array of diseases, including myocardial infarction, cerebral stroke, and cancer (1)(2)(3). Albeit highly desirable, this challenge has not yet been met.…”

mentioning

confidence: 99%

Molecular Imaging of Neurovascular Cell Death in Experimental Cerebral Stroke by PET

Reshef

Shirvan²,

Waterhouse³

et al. 2008

J Nucl Med

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mentioning

confidence: 99%

Molecular Imaging of Neurovascular Cell Death in Experimental Cerebral Stroke by PET

Reshef

Shirvan²,

Waterhouse³

et al. 2008

J Nucl Med

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“…Both of them act synergistically to produce the mitochondrial permeability transition and cell death. The local production of ROS and myocardial Ca 2+ homeostasis disturbances have been proposed to be the determinants of oxy-radicals and the calcium hypothesis [1].…”

Section: Discussionmentioning

confidence: 99%

“…Although we have effective treatment modalities for AMI, survivors still carry increased risks for heart failure, sudden death and all-cause mortality [1]. Cell death can occur in a destructive, uncontrolled manner via necrosis or by a programmed cell suicide mechanism termed 'apoptosis'.…”

Section: Introductionmentioning

confidence: 99%

“…However, cumulative evidence indicates that apoptosis also plays an important role in the process of myocyte damage subsequent to myocardial infarction (MI) [1]. Although there are many suggestions regarding apoptotic machinery, the exact mechanisms underlying the induction of this apoptotic process in myocardial ischemia-reperfusion (MI/R) are not completely understood.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Selective Endothelin Receptor a Antagonism by Bq-123 on Myocardial Ischemia-Reperfusion Induced Apoptotic Cell Death

Çolak¹,

Parlakpınar²,

Ermiş³

et al. 2012

Med-Science

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The objective of the present study was to investigate the possible impact of specific endothelin-A (ET A ) receptor blockage by BQ-123 on myocardial ischemia-reperfusion (MI/R) induced apoptosis in rats. To produce MI/R, a branch of the descending left coronary artery was occluded for 30 min followed by 2 h reperfusion. Thirty-two rats were randomly assigned to four groups equally: (1) sham-operated group, (2) MI/R group, (3) MI/R+BQ-123-treated group, and (4) MI/R+ET-1+BQ

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“…Ischemia is a complex process with several phases that are characterized in different tissues by the release of several molecules including inflammation markers, growth factors and small molecules. Cell death in the ischemic region is due to a mixture of necrosis and apoptosis, with different time courses and locations [7,8]. Apoptosis can be in vivo detected using the exposition of phosphatidylserine as a simple marker.…”

Section: Introductionmentioning

confidence: 99%

Homing of annexin-labeled stem cells to apoptotic cells

Gerasimou¹,

Ramella²,

Brero³

et al. 2009

Cellular and Molecular Biology Letters

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Ischemic diseases are characterized by the presence of pro-apoptotic stimuli, which initiate a cascade of processes that lead to cell injury and death. Several molecules and events represent detectable indicators of the different stages of apoptosis. Among these indicators is phosphatidylserine (PS) translocation from the inner to the outer leaflet of the plasma membrane, which can be detected by annexinV (ANXA5) conjugation. This is a widely used in vivo and in vitro assay marking the early stages of apoptosis. We report here on an original method that employs PS-ANXA5 conjugation to target stem cells to apoptotic cells. Mesenchymal stem cells (MSCs) from GFP-positive transgenic rats were biotinylated on membrane surfaces with sulfosuccinimidyl-6-(biotinamido) hexanoate (sulfo-NHS-LC-biot) and then bound to avidin. The avidin-biotinylated MSCs were labeled with biotin conjugated ANXA5. Bovine aortic endothelial cells (BAE-1 cells) were exposed to UVC to induce caspasedependent apoptosis. Finally, we tested the ability of ANXA5-labeled MSCs to Unauthenticated Download Date | 5/11/18 2:02 AM CELLULAR & MOLECULAR BIOLOGY LETTERS 101 bind BAE-1 apoptotic cells: suspended ANXA5-labeled MSCs were seeded for 1 hour on a monolayer of UV-treated or control BAE-1 cells. After washing, the number of MSCs bound to BAE-1 cells was evaluated by confocal microscopy. Statistical analysis demonstrated a significant increase in the number of MSCs tagged to apoptotic BAE-1 cells. Therefore, stem cell ANXA5 tagging via biotin-avidin bridges could be a straightforward method of improving homing to apoptotic tissues.

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Acute myocardial infarction and heart failure: Role of apoptosis

Cited by 151 publications

References 28 publications

Molecular Imaging of Neurovascular Cell Death in Experimental Cerebral Stroke by PET

Molecular Imaging of Neurovascular Cell Death in Experimental Cerebral Stroke by PET

The Effect of Selective Endothelin Receptor a Antagonism by Bq-123 on Myocardial Ischemia-Reperfusion Induced Apoptotic Cell Death

Homing of annexin-labeled stem cells to apoptotic cells

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