Acute myocardial infarction and acute heart failure in the Middle East and North Africa: Study design and pilot phase study results from the PEACE MENA registry

AlHabib, Khalid F.; Gamra, Habib; Almahmeed, Wael; Hammoudeh, Ayman; Benkheddah, Salim; Jarallah, Mohammad Al; Al‐Motarreb, Ahmed; Alquraishi, Mothanna; Sobhy, Mohamed; Yousif, Magdi G.; Alkindi, Fahad; Fellat, Nadia; Amin, Mohammad I.; Ali, Muhammad; Saleh, Ayman Al; Ullah, Anhar; Zannad, Faı̈ez

doi:10.1371/journal.pone.0236292

Cited by 10 publications

(7 citation statements)

References 25 publications

(40 reference statements)

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“…The full study design has been described elsewhere [ 5 ]. Briefly, the study was divided into three phases.…”

Section: Methodsmentioning

confidence: 99%

Clinical features, socioeconomic status, management, short and long-term outcomes of patients with acute myocardial infarction: Phase I results of PEACE MENA registry

Al Saleh,

Jamee,

Sulaiman

et al. 2024

PLoS ONE

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Background The Program for the Evaluation and Management of Cardiac Events in the Middle East and North Africa (PEACE MENA) is a prospective registry program in Arabian countries that involves in patients with acute myocardial infarction (AMI) or acute heart failure (AHF). Methods This prospective, multi-center, multi-country study is the first report of the baseline characteristics and outcomes of inpatients with AMI who were enrolled during the first 14-month recruitment phase. We report the clinical characteristics, socioeconomic, educational levels, and management, in-hospital, one month and one-year outcomes. Results Between April 2019 and June 2020, 1377 patients with AMI were enrolled (79.1% males) from 16 Arabian countries. The mean age (± SD) was 58 ± 12 years. Almost half of the population had a net income < $500/month, and 40% had limited education. Nearly half of the cohort had a history of diabetes mellitus, hypertension, or hypercholesterolemia; 53% had STEMI, and almost half (49.7%) underwent a primary percutaneous intervention (PCI) (lowest 4.5% and highest 100%). Thrombolytics were used by 36.2%. (Lowest 6.45% and highest (90.9%). No reperfusion occurred in 13.8% of patients (lowest was 0% and highest 72.7%).Primary PCI was performed less frequently in the lower income group vs. high income group (26.3% vs. 54.7%; P<0.001). Recurrent ischemia occurred more frequently in the low-income group (10.9% vs. 7%; P = 0.018). Re-admission occurred in 9% at 1 month and 30% at 1 year, whereas 1-month mortality was 0.7% and 1-year mortality 4.7%. Conclusion In the MENA region, patients with AMI present at a young age and have a high burden of cardiac risk factors. Most of the patients in the registry have a low income and low educational status. There is heterogeneity among key performance indicators of AMI management among various Arabian countries.

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“…The full study design has been described elsewhere [ 5 ]. Briefly, the study was divided into three phases.…”

Section: Methodsmentioning

confidence: 99%

Clinical features, socioeconomic status, management, short and long-term outcomes of patients with acute myocardial infarction: Phase I results of PEACE MENA registry

Al Saleh,

Jamee,

Sulaiman

et al. 2024

PLoS ONE

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“…(1)(2)(3) Despite recent advances in its treatment, reported in clinical guidelines, (4,5) in low/middle income settings it can be difficult to treat a patient with acute myocardial infarction correctly. (3,6) As indicated in the long-tErm follow uP of antithrombotic management patterns in AcutE CORonary syndrome patients (EPICOR) Registry, (7) Latin America was the third region with the most patients who did not receive any reperfusion strategy, (surpassed only by India and China), the third with the longest delay until coronary intervention, (again surpassed by China and India), and the one with the highest mortality at 23 months of follow-up.…”

Section: Introductionmentioning

confidence: 99%

“… 1-3 Despite recent advances in its treatment, reported in clinical guidelines, 4 , 5 in low/middle income settings it can be difficult to treat a patient with acute myocardial infarction correctly. 3 , 6 …”

Section: Introductionmentioning

confidence: 99%

Quality of care for patients with ST-segment Elevation Myocardial Infarction before COVID-19 pandemic in Cuba.

Remedios-Carbonell,

Arteaga-Guerra,

Prieto-Guerra

et al. 2023

Rev Fac Cien Med Univ Nac Cordoba

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Background: In Cuba, there is neither a registry of ST Elevation Myocardial Infarction (STEMI), nor are analysis of performance measures widely reported.Objective: A review of Cuban studies of patients with STEMI was carried out to describe quality of medical care.Methods: Cochrane Library, EMBASE, PubMed, Scopus and SciELO, as well as archives of national journals, were all searched for articles on STEMI in Cuba, from 2000 to March 2020. They were included if they reported number or percentage of application of reperfusion therapy; administration of aspirin, enalapril-captopril (ACEI) or beta-blockers; status of patients at discharge; and patient or system delay times. Finally, 17 reports with 7823 patients were included.Results: Thrombolytic therapy was administered to 3991 patients (51%), and 695 patients (8.9%) died. Only four studies, with 880 patients, presented data about prescription of ACEI, aspirin, and beta-blockers, which were administered to 381 (45.3%), 824 (93.6%), 464 (52.7%) patients, respectively. Coronary intervention was reported in 5 studies with 3422 patients, being performed in 661 (19.3%). Conclusions: Quality of care of patients with STEMI seems to be poorer than reported in similar scenarios. Thrombolytic administration is still low, although mortality decreases in this period. Other pharmacological treatments were insufficiently fulfilled.

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“…In the Middle East and North Africa (MENA) regions, dramatic and rapid lifestyle changes in recent years have led to an increase in the prevalence of CV risk factors and, consequently, a rise in CV mortality at younger ages, influenced by lower incomes [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Cardiovascular Risk Factors and Coronary Angiographic Findings in High-Risk Immigrant Communities in Italy

Muscoli

Andreadi

Tamburro

et al. 2023

JPM

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Background: The prevalence of coronary artery disease (CAD) considerably varies by ethnicity. High-risk populations include patients from Eastern Europe (EEP), the Middle East and North Africa (MENAP) and South Asia (SAP). Methods: This retrospective study aims to highlight cardiovascular risk factors and specific coronary findings in high-risk immigrant groups. We examined the medical records and coronary angiographies of 220 patients from the above-mentioned high-risk ethnic groups referred for Acute Coronary Syndrome (ACS) and compared them with 90 Italian patients (IP) from 2016 to 2021. In the context of high-risk immigrant populations, this retrospective study aims to shed light on cardiovascular risk factors and particular coronary findings. We analyzed the medical records of 220 patients from the high-risk ethnic groups described above referred for ACS and compared them with 90 IPs between 2016 and 2021. In addition, we assessed coronary angiographies with a focus on the culprit lesion, mainly evaluating multi-vessel and left main disease. Results: The mean age at the first event was 65.4 ± 10.2 years for IP, 49.8 ± 8.5 years for SAP (Relative Reduction (ReR) 30.7%), 51.9 ± 10.2 years for EEP (ReR 26%) and 56.7 ± 11.4 years for MENAP (ReR 15.3%); p < 0.0001. The IP group had a significantly higher prevalence of hypertension. EEP and MENAP had a lower prevalence of diabetes. EEP and MENAP had a higher prevalence of STEMI events; SAP showed a significant prevalence of left main artery disease (p = 0.026) and left anterior descending artery disease (p = 0.033) compared with other groups. In SAP, we detected a higher prevalence of three-vessel coronary artery disease in the age group 40–50. Conclusions: Our data suggest the existence of a potential coronary phenotype in several ethnicities, especially SAP, and understate the frequency of CV risk factors in other high-risk groups, supporting the role of a genetic influence in these communities.

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Acute myocardial infarction and acute heart failure in the Middle East and North Africa: Study design and pilot phase study results from the PEACE MENA registry

Cited by 10 publications

References 25 publications

Clinical features, socioeconomic status, management, short and long-term outcomes of patients with acute myocardial infarction: Phase I results of PEACE MENA registry

Clinical features, socioeconomic status, management, short and long-term outcomes of patients with acute myocardial infarction: Phase I results of PEACE MENA registry

Quality of care for patients with ST-segment Elevation Myocardial Infarction before COVID-19 pandemic in Cuba.

Prevalence of Cardiovascular Risk Factors and Coronary Angiographic Findings in High-Risk Immigrant Communities in Italy

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