Acute myeloid leukemia with marrow hypereosinophilia and chromosome 16 [letter]

Bernard, P; Dachary, Dominique; Lacombe, Francis; boisseau,; David, B.; Broustet, A

doi:10.1182/blood.v63.1.243a.bloodjournal631243a

Cited by 3 publications

(2 citation statements)

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“…The cytogenetic abnormality inv(16) (p13.1q22) or t(16; 16) (p13.1; q22); CBFB-MYH11 is associated with varying degrees of eosinophilia. 15 Bone marrow eosinophilia may also be seen in AML with t(8; 21) (q22; q22); RUNX1-RUNX1T1. 16 Acute lymphoblastic leukemias have also been associated with peripheral blood and marrow eosinophilia.…”

Section: Clonality Of the T-cells May Be Demonstrable Through Analysimentioning

confidence: 99%

Management of hypereosinophilia in tropical settings

Law

Varma

2015

Medical Journal Armed Forces India

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Hypereosinophilia includes a group of commonly encountered clinical situations with symptoms ranging from mild and clinically innocuous to devastating presentations with high morbidity and mortality. The presentations and complications can be easily missed if the clinician is unaware of the diverse entities responsible for hypereosinophilia. The hypereosinophilic syndromes encompass entities that are associated with varying degrees of organ dysfunction either directly due to eosinophilic infiltration or as a result of substances secreted by the eosinophils. These conditions may be neoplastic or reactive in aetiology and a diligent search for secondary causes is essential. Evaluation and management algorithms in the tropical setting and in developing countries may differ from elsewhere. A review of hypereosinophilia and hypereosinophilic syndromes is presented with a diagnostic and therapeutic decision making algorithm modified for use in the tropical setting.

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Section: Clonality Of the T-cells May Be Demonstrable Through Analysimentioning

confidence: 99%

Management of hypereosinophilia in tropical settings

Law

Varma

2015

Medical Journal Armed Forces India

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“…Specific abnormalities of chromosome 16 have been reported in patients with acute nonlymphocytic leukaemia (ANLL) (1)(2)(3)(4)(5)(6). Especially, strong correlation between pericentric inversion of chromosome 16, inv(16)(p13q22), and acute myelomonocytic leukaemia (AMMoL) (FAB M4) with abnormal bone marrow eosinophils has been demonstrated.…”

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confidence: 99%

An increase in basophils in a case of acute myelomonocytic leukaemia associated with marrow eosinophilia and inversion of chromosome 16

Matsuura

Sato

Kimura

et al. 1987

European J of Haematology

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A patient with acute myelomonocytic leukaemia (M4 subtype) with pericentric inversion of chromosome 16, inv(16)(p13q22), and a marked basophilia is described. Results from transmission electron microscopy suggested that the basophils were immature. Clinically, although leukaemic cells had a tendency to infiltrate a number of tissues and organs, such as skin, gingiva, liver and lung, the patient was successfully treated with chemotherapy. The increase in basophils accompanied by marrow eosinophilia may be the result of abnormal differentiation of leukaemic cells that have the capacity to differentiate into both the eosinophilic and basophilic pathways.

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