Acute myeloid leukemia in the vascular niche

Cogle, Christopher R.; Bosse, Raphael C.; Brewer, Takae; Migdady, Yazan; Shirzad, Reza; Kampen, Kim R.; Saki, Najmaldin

doi:10.1016/j.canlet.2015.05.007

Cited by 49 publications

(34 citation statements)

References 86 publications

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“…Within AML, patients have increased bone marrow microvascular density [96] and overexpression of VEGF [97]. Additionally, endothelial cells provide adhesive support and protection from chemotherapy to AML cells, even allowing for potential integration into blood vessels (recently reviewed in [98]). Similarly, CXCL-12-abundant reticular (CAR) cells that surround sinusoidsal endothelial cells (but can also be found in the endosteum) are the major producers of CXCL12 (SDF-1) within the bone marrow and are thought to also contribute to maintaining the HSCs pool [99].…”

Section: Accepted Manuscriptmentioning

confidence: 98%

The role of platelets in the tumor microenvironment: From solid tumors to leukemia

Yan¹,

Jurasz²

2016

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

152

109

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Platelets are increasingly being recognized for promoting tumor growth and metastasis. Many cells derived from solid tumors have the ability to aggregate platelets, and this ability correlates with their metastatic potential. Over the past half century, our understanding of tumor cell-induced platelet aggregation (TCIPA) has grown beyond the simple concept that tumor cell-containing microthrombi mechanically embolize the microvasculature. Tumor cell-activated platelets secrete a multitude of factors that reciprocally act on tumor cells, as well as other cells within the tumor microenvironment; thus, affecting both parenychma and tumor-associated stroma. In this review, we summarize the current knowledge of tumor cell-platelet interactions and their influence on the tumor microenvironment, including how these interactions impact neoplastic epithelial cells, endothelial cells, pericytes, fibroblasts, immune cells, and early metastatic niches. In addition, we review the current knowledge of platelet-cancer cell interactions within hematological malignancies and speculate on how platelets may influence the leukemic microenvironment. This article is part of a Special Issue entitled: Tumor Microenvironment Regulation of Cancer Cell Survival, Metastasis, Inflammation, and Immune Surveillance edited by Peter Ruvolo and Gregg L. Semenza.

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Section: Accepted Manuscriptmentioning

confidence: 98%

The role of platelets in the tumor microenvironment: From solid tumors to leukemia

Yan¹,

Jurasz²

2016

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

152

109

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“…However, with evidence suggesting the importance of the bone marrow microenvironment for hematopoiesis, it is necessary to broaden the scope of investigation beyond the leukemia cell. Angiogenesis plays an important role in the development, progression and relapse of AML [4], and antiangiogenic therapy could constitute a novel strategy for the treatment of AML. Thalidomide, a putative inhibitor of angiogenesis, has significant anti-angiogenic activity in AML [5,6].…”

Section: Introductionmentioning

confidence: 99%

Thalidomide in Combination with Chemotherapy in Treating Elderly Patients with Acute Myeloid Leukemia

Chen¹,

Yang²,

Xu³

2018

Oncol Res Treat

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Background: Currently, the treatment decisions in elderly patients with acute myeloid leukemia (AML) are difficult and remain controversial. This study aims to evaluate the effect of thalidomide plus chemotherapy on elderly patients with AML. Methods: 70 elderly AML patients (median age 71 years) were enrolled into this prospective study and randomly assigned to either the control arm (PC, n = 35) or the investigational arm (TPC, n = 35). Patients in the PC arm received a non-intensive regimen composed of cytarabine, aclarubicin and G-CSF (CAG) chemotherapy for induction of remission, and patients in the TPC arm received in addition thalidomide at a maximum dose of 200 mg/day. Results: After 2 courses of induction therapy, complete response rate of TPC and PC arms was 54.3% and 57.1%, respectively (p = 0.810). At the last follow-up, the Kaplan-Meier estimate showed that the median overall survival (OS) and event-free survival (EFS) in patients in the PC arm was inferior to those of patients in the TPC arm. Using a stratified Cox model adjusted for randomized treatment, patients receiving thalidomide plus chemotherapy were shown to derive some survival benefit in both OS and EFS. Overall, the hematological and non-hematological toxicity were similar between the 2 treatment arms. Conclusions: Thalidomide in combination with chemotherapy is an alternative treatment option for elderly patients with AML.

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“…On the other hand, the expression of some adhesion molecules is increased on the surface of ECs, which is involved in leukemia cell binding to Ecs. 64,94 The leukemia cells orientate towards the blood vessel walls, exit from the cell cycle and enter into a state of quiescence. Therefore, ECs are tightly juxtaposed and prevent the permeation of chemotherapeutic agents into the vessel, which causes the resistance of leukemia cells to chemotherapy drugs.…”

Section: Discussion and Future Perspectivementioning

confidence: 99%

Bone marrow blood vessels: normal and neoplastic niche

et al. 2016

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Blood vessels are among the most important factors in the transport of materials such as nutrients and oxygen. This study will review the role of blood vessels in normal bone marrow hematopoiesis as well as pathological conditions like leukemia and metastasis. Relevant literature was identified by a Pubmed search (1992-2016) of English-language papers using the terms bone marrow, leukemia, metastasis, and vessel. Given that blood vessels are conduits for the transfer of nutrients, they create a favorable situation for cancer cells and cause their growth and development. On the other hand, blood vessels protect leukemia cells against chemotherapy drugs. Finally, it may be concluded that the vessels are an important factor in the development of malignant diseases.

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Acute myeloid leukemia in the vascular niche

Cited by 49 publications

References 86 publications

The role of platelets in the tumor microenvironment: From solid tumors to leukemia

The role of platelets in the tumor microenvironment: From solid tumors to leukemia

Thalidomide in Combination with Chemotherapy in Treating Elderly Patients with Acute Myeloid Leukemia

Bone marrow blood vessels: normal and neoplastic niche

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