Acute Myelogeneous Leukemia (M5a) that Demonstrated Chromosomal Abnormality of Robertsonian 13;21 Translocation at Onset

Shimokawa, Takayoshi; Sakai, Mayuko; Kojima, Yumi; Takeyama, Hideo

doi:10.2169/internalmedicine.43.508

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…Rb translocations in humans constitute the most common structural genetic abnormalities in aborted fetuses and newborns [Jacobs, 1981;Nielsen and Wohlert, 1991;Kim and Shaffer, 2002]. Moreover, human Rb translocation chromosomes have been found as acquired or constitutional genetic lesions in hematological cancers [Qian et al, 2002;Welborn, 2004], in solid tumors [Padilla-Nash et al, 2001;Bayani et al, 2003], and at the onset of acute myelogenous leukemia [Shimokawa et al, 2004].…”

Section: Centromere Evolution Speciation Structural Abnormalities Amentioning

confidence: 99%

Centromeres in cell division, evolution, nuclear organization and disease

Silva¹,

Sarkar²,

Harizanova³

et al. 2008

J of Cellular Biochemistry

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As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and tumor cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division.

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Section: Centromere Evolution Speciation Structural Abnormalities Amentioning

confidence: 99%

Centromeres in cell division, evolution, nuclear organization and disease

Silva¹,

Sarkar²,

Harizanova³

et al. 2008

J of Cellular Biochemistry

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Chronic myelogenous leukemia exhibiting trisomy 14 due to a Robertsonian translocation with philadelphia chromosome

et al. 2008

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A Balanced Robertsonian Translocation in a Patient with a Janus Kinase 2–Positive Polycythemia Vera

Strasser

Paar

Kiesl

et al. 2021

Laboratory Medicine

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A male patient with a persistent, combined erythrocytosis, leukocytosis, and thrombocytosis without representative evidence of reactive increase emerged as having a myeloproliferative disorder. Molecular-biological assessment yielded Janus kinase 2–positive results, and the patient was diagnosed with polycythemia vera. In addition to these findings, further karyotyping accounted for a Robertsonian translocation. Because this rearrangement was a balanced variant, we concluded that this cytogenetic result might not significantly alter the diagnosis of polycythemia vera.

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Acute Myelogeneous Leukemia (M5a) that Demonstrated Chromosomal Abnormality of Robertsonian 13;21 Translocation at Onset

Abstract: A 27-year-old woman had congenital lissencephaly syndrome and mental retardation. She had a fever of unknown origin and visited her local physician. Blood test indicated leukocytosis, so she was referred to our hospital for detailed examination.

Cited by 6 publications

References 13 publications

Centromeres in cell division, evolution, nuclear organization and disease

Centromeres in cell division, evolution, nuclear organization and disease

Chronic myelogenous leukemia exhibiting trisomy 14 due to a Robertsonian translocation with philadelphia chromosome

A Balanced Robertsonian Translocation in a Patient with a Janus Kinase 2–Positive Polycythemia Vera

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