Acute myelitis as a neurological complication of Covid-19: A case report and MRI findings

AlKetbi, Reem; AlNuaimi, Dana; AlMulla, Muna; Al-Talai, Nouf; Samir, M.; Kumar, Navin; Albastaki, Usama

doi:10.1016/j.radcr.2020.06.001

Cited by 96 publications

(117 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Spinal imaging displayed impressions indicative of acute transverse myelitis, which was confirmed on follow-up MRI [37]. Patients with acute myelitis manage to affect regions of the central spinal segments that appear hyperintense on T2 sequences with possible cord swelling and display variable contrast enhancement [38]. In this case report, the disease course markedly improved following treatment with methylprednisolone [37].…”

Section: Acute Transverse Myelitis|acute Necrotizing Myelitismentioning

confidence: 52%

The Neurological Complexities and Prognosis of COVID-19

Padda

Khehra

Jaferi

et al. 2020

SN Compr. Clin. Med.

View full text Add to dashboard Cite

Several neurological manifestations and complications linked to SARS-CoV-2 have been reported along with well-known respiratory pathology. The global active transmission of SARS-CoV-2 and its unexplained characteristics has led to a pandemic. Since its rapid emergence from Wuhan, China, in December 2019, several studies have reported the impacts of COVID-19 on the CNS and PNS and its implications. This comprehensive review article comprises case reports, case series, metaanalysis, cohort studies, retrospective studies, and narrative reviews focusing on COVID-19-associated CNS and PNS complexities. The authors searched for over 200 articles and used 52 publications related to the neurological complexities of COVID-19 affecting the CNS and PNS as part of the literature review process. The predominant CNS symptoms noted in COVID-19 patients were headaches and dizziness, and the most common PNS symptoms were alterations in smell and taste. Case reports on headache/dizziness, intracerebral hemorrhage, acute hemorrhagic necrotizing encephalopathy, meningitis/encephalitis, encephalopathy, cerebrovascular events, chemosensory dysfunction, Guillain-Barre syndrome, and acute transverse myelitis/acute necrotizing myelitis in PCR-confirmed SARS-CoV-2 subjects are also reported. New-onset neurological symptoms were also observed in children with PCR-confirmed SARS-CoV-2 that developed pediatric multisystem inflammatory syndrome (PIMS). This comprehensive review article will assist the clinicians and researchers to gain information about the neurological manifestations and complications associated with COVID-19 and develop planning to treat these symptoms in concerned patients of all ages. However, it is unclear whether SARS-CoV2-associated neurological effects are due to primary infections or secondary response to the possible mechanisms discussed in this review.

show abstract

Section: Acute Transverse Myelitis|acute Necrotizing Myelitismentioning

confidence: 52%

The Neurological Complexities and Prognosis of COVID-19

Padda

Khehra

Jaferi

et al. 2020

SN Compr. Clin. Med.

View full text Add to dashboard Cite

show abstract

“…Little is known about association between SARS-CoV-2 and acute myelitis. Up to date, 7 cases of acute myelitis, alone (4 cases) or combined with brain involvement (3 cases), have been reported in relation to COVID-19 ( AlKetbi et al, 2020 , Munz et al, 2020 , Novi et al, 2020 , Sarma and Bilello, 2020 , Valiuddin et al, 2020 , Wong, Craik, 2020a, Zanin, Saraceno, 2020). Six patients (28–64 years age range, 57.1% female) variably had symptoms of COVID-19 (fever, dyspnea, malaise, chills, and rhinorrhea) 25 to 2 days prior the onset of neurologic symptoms of myelitis ( Table 3 ).…”

Section: Neurologic Manifestationsmentioning

confidence: 99%

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

Keyhanian

Umeton

Mohit

et al. 2021

Journal of Neuroimmunology

113

139

View full text Add to dashboard Cite

Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.

show abstract

“…There are reports of COVID patients with rhombencephalitis [151] and meningoencephalitis [159], some with positive Sars-CoV2 in the CSF [92], most of which presented with seizures and encephalopathy. Acute haemorrhagic leukoencephalitis [108], demyelinating lesions [162], ADEM [102] and acute myelitis have also been reported [2]. Peripheral nervous system manifestations include anosmia/ageusia in over 80% of infected [73], GBS (both demyelinating and axonal) [138], Miller-Fisher syndrome (MFS) and isolated abducens palsies [48].…”

Section: Sars-cov-2mentioning

confidence: 99%

The neurological sequelae of pandemics and epidemics

et al. 2020

View full text Add to dashboard Cite

Neurological manifestations in pandemics frequently cause short and long-term consequences which are frequently overlooked. Despite advances in the treatment of infectious diseases, nervous system involvement remains a challenge, with limited treatments often available. The under-recognition of neurological manifestations may lead to an increase in the burden of acute disease as well as secondary complications with long-term consequences. Nervous system infection or dysfunction during pandemics is common and its enduring consequences, especially among vulnerable populations, are frequently forgotten. An improved understanding the possible mechanisms of neurological damage during epidemics, and increased recognition of the possible manifestations is fundamental to bring insights when dealing with future outbreaks. To reverse this gap in knowledge, we reviewed all the pandemics, large and important epidemics of human history in which neurological manifestations are evident, and described the possible physiological processes that leads to the adverse sequelae caused or triggered by those pathogens.

show abstract

Acute myelitis as a neurological complication of Covid-19: A case report and MRI findings

Cited by 96 publications

References 14 publications

The Neurological Complexities and Prognosis of COVID-19

The Neurological Complexities and Prognosis of COVID-19

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

The neurological sequelae of pandemics and epidemics

Contact Info

Product

Resources

About