Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice
Juanzi Gao,
Anmin Wang,
Xiangyi Bu
et al.
Abstract:IntroductionHuman cytomegalovirus (HCMV) infection in infants can lead to severe diseases, including neonatal hepatitis. The single-cell dimensional changes in immune cells after the initial CMV infection remain elusive, as do the effects of CMV infection on hepatic lipid metabolism. MethodsWe employed single-cell RNA-sequencing to investigate the changes in liver cell types and immune responses in infant mice following murine CMV (MCMV) infection. Additionally, we examined alterations in protein expression pr… Show more
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