Acute Mountain Sickness; Prophylactic Benefits of Antioxidant Vitamin Supplementation at High Altitude

Bailey, Damian Miles; Davies, Bruce

doi:10.1089/152702901750067882

Cited by 130 publications

(91 citation statements)

References 21 publications

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“…There is no doubt that acute exposure to a high altitude will cause pathological stress leading to oxidative stress [34]. Our study showed that the protection of the mitochondria by CO-HBOC also played an important role in the cardiac protective effect.…”

Section: Discussionmentioning

confidence: 58%

Carbon Monoxide-Saturated Hemoglobin-Based Oxygen Carriers Attenuate High-Altitude-Induced Cardiac Injury by Amelioration of the Inflammation Response and Mitochondrial Oxidative Damage

Wang

Hu²,

Hu³

et al. 2016

Cardiology

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Objective: To investigate the therapeutic effect of carbon monoxide (CO) on high-altitude hypoxia-induced cardiac damage. Methods: Forty male C57BL/6 mice were randomly divided into 4 groups. The mice were exposed to normoxia or simulated 5,500-meter high-altitude hypoxia in a hypobaric chamber for 7 days. During the first 3 days, the mice were pretreated with CO-saturated hemoglobin (Hb)-based oxygen carrier (CO-HBOC), oxygen-saturated hemoglobin-based oxygen carrier (O₂-HBOC) at a dose of 0.3 g Hb/kg/day or an equivalent volume of saline. The in vivo left ventricle function, cardiac enzyme release, histopathological changes, apoptosis and inflammation were also measured. Results: High-altitude hypoxia induced significant cardiac damage, as demonstrated by impaired cardiac function and increased proapoptotic, proinflammatory and pro-oxidant markers. Pretreatment with CO-HBOC significantly improved cardiac performance, reduced cardiac enzyme release and limited myocardial apoptosis. The increased inflammatory response was also suppressed. In addition to the preserved mitochondrial structure, hypobaric hypoxia-induced mitochondrial oxidative damage was remarkably attenuated. Moreover, these antiapoptotic and antioxidative effects were accompanied by an upregulated phosphorylation of Akt, ERK and STAT3. Conclusion: This study demonstrated that CO-HBOC provides a promising protective effect on high-altitude hypoxia-induced myocardial injury, which is mediated by the inhibition of inflammation and mitochondrial oxidative damage.

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Section: Discussionmentioning

confidence: 58%

Carbon Monoxide-Saturated Hemoglobin-Based Oxygen Carriers Attenuate High-Altitude-Induced Cardiac Injury by Amelioration of the Inflammation Response and Mitochondrial Oxidative Damage

Wang

Hu²,

Hu³

et al. 2016

Cardiology

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“…Gingko's effects may be because of its antioxidant activity. This concept is supported by data suggesting that ingestion of antioxidant vitamins may reduce the incidence and severity of AMS [40].…”

Section: Gingko Bilobamentioning

confidence: 77%

Prevention and treatment of high-altitude illness in travelers

Murdoch

2004

Curr Infect Dis Rep

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High-altitude illness is the collective term for acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE). These syndromes can affect unacclimatized travelers shortly after ascent to high altitude (especially higher than 2500 m). AMS is relatively common and usually is mild and self-limiting; HACE and HAPE are uncommon but life-threatening. Gradual ascent is the best strategy for preventing or minimizing high-altitude illness, although chemoprophylaxis may be useful in some situations. Acetazolamide remains the chemoprophylactic agent of choice, although other drugs, such as gingko biloba, are being investigated. Immediate descent remains the cornerstone of treatment for HACE and HAPE, although pharmacologic and hyperbaric therapies may facilitate this process.

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“…Taken together, this evidence strongly suggests that combining ALA and VE is better than monotherapy. In parallel, the ALA-VE mixture has been combined with other dietary antioxidants, such as vitamin C, beta-carotene, and selenium, and evaluated under several conditions of exercise, experimental diabetes, cold, age and cancer, and promising results have also been obtained [46][47][48][49][50][51].…”

Section: Synergism Between Lipoate and Tocopherolmentioning

confidence: 99%

Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

González-Pérez

González-Castañeda

2006

Nutrition Research

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Alpha-lipoic acid and vitamin E have synergistic effects, as determined in models of oxidant radical lesions. This review summarizes recent findings showing that the combination of alpha-lipoic acid plus vitamin E has beneficial effects in reducing oxidative damage in ischemic or other oxidationrelated pathological events. Both antioxidants are common in the normal human diet and side effects are very rare. Therefore, alpha-lipoic acid and vitamin E can counteract oxidative processes and could have an important role in clinical medicine.

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Acute Mountain Sickness; Prophylactic Benefits of Antioxidant Vitamin Supplementation at High Altitude

Cited by 130 publications

References 21 publications

Carbon Monoxide-Saturated Hemoglobin-Based Oxygen Carriers Attenuate High-Altitude-Induced Cardiac Injury by Amelioration of the Inflammation Response and Mitochondrial Oxidative Damage

Carbon Monoxide-Saturated Hemoglobin-Based Oxygen Carriers Attenuate High-Altitude-Induced Cardiac Injury by Amelioration of the Inflammation Response and Mitochondrial Oxidative Damage

Prevention and treatment of high-altitude illness in travelers

Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

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